The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes
Cryonotothenioidea is the main group of fishes that thrive in the extremely cold Antarctic environment, thanks to the acquisition of peculiar morphological, physiological and molecular adaptations. We have previously disclosed that IgM, the main immunoglobulin isotype in teleosts, display typical co...
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Online Access: | http://hdl.handle.net/11368/2993650 https://doi.org/10.1016/j.fsi.2021.05.015 https://www.sciencedirect.com/science/article/pii/S1050464821001431 |
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ftunitriestiris:oai:arts.units.it:11368/2993650 2023-05-15T13:54:31+02:00 The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes Ametrano, Alessia Gerdol, Marco Vitale, Maria Greco, Samuele Oreste, Umberto Coscia, Maria Rosaria Ametrano, Alessia Gerdol, Marco Vitale, Maria Greco, Samuele Oreste, Umberto Coscia, Maria Rosaria 2021 http://hdl.handle.net/11368/2993650 https://doi.org/10.1016/j.fsi.2021.05.015 https://www.sciencedirect.com/science/article/pii/S1050464821001431 eng eng info:eu-repo/semantics/altIdentifier/pmid/34038801 info:eu-repo/semantics/altIdentifier/wos/WOS:000682963400001 volume:116 firstpage:124 lastpage:139 numberofpages:16 journal:FISH AND SHELLFISH IMMUNOLOGY http://hdl.handle.net/11368/2993650 doi:10.1016/j.fsi.2021.05.015 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85109519730 https://www.sciencedirect.com/science/article/pii/S1050464821001431 info:eu-repo/semantics/openAccess Teleost fish Notothenioidei Genome modification IgT Exonic remnant Immunoglobulin domain Antarctic marine environment Molecular evolution info:eu-repo/semantics/article 2021 ftunitriestiris https://doi.org/10.1016/j.fsi.2021.05.015 2023-04-09T06:20:08Z Cryonotothenioidea is the main group of fishes that thrive in the extremely cold Antarctic environment, thanks to the acquisition of peculiar morphological, physiological and molecular adaptations. We have previously disclosed that IgM, the main immunoglobulin isotype in teleosts, display typical cold-adapted features. Recently, we have analyzed the gene encoding the heavy chain constant region (CH) of the IgT isotype from the Antarctic teleost Trematomus bernacchii (family Nototheniidae), characterized by the near-complete deletion of the CH2 domain. Here, we aimed to track the loss of the CH2 domain along notothenioid phylogeny and to identify its ancestral origins. To this end, we obtained the IgT gene sequences from several species belonging to the Antarctic families Nototheniidae, Bathydraconidae and Artedidraconidae. All species display a CH2 remnant of variable size, encoded by a short Cτ2 exon, which retains functional splicing sites and therefore is included in the mature transcript. We also considered representative species from the three non-Antarctic families: Eleginopsioidea (Eleginops maclovinus), Pseudaphritioidea (Pseudaphritis urvillii) and Bovichtidae (Bovichtus diacanthus and Cottoperca gobio). Even though only E. maclovinus, the sister taxa of Cryonotothenioidea, shared the partial loss of Cτ2, the other non-Antarctic notothenioid species displayed early molecular signatures of this event. These results shed light on the evolutionary path that underlies the origins of this remarkable gene structural modification. Article in Journal/Newspaper Antarc* Antarctic Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) Antarctic The Antarctic Fish & Shellfish Immunology 116 124 139 |
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Open Polar |
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Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
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ftunitriestiris |
language |
English |
topic |
Teleost fish Notothenioidei Genome modification IgT Exonic remnant Immunoglobulin domain Antarctic marine environment Molecular evolution |
spellingShingle |
Teleost fish Notothenioidei Genome modification IgT Exonic remnant Immunoglobulin domain Antarctic marine environment Molecular evolution Ametrano, Alessia Gerdol, Marco Vitale, Maria Greco, Samuele Oreste, Umberto Coscia, Maria Rosaria The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes |
topic_facet |
Teleost fish Notothenioidei Genome modification IgT Exonic remnant Immunoglobulin domain Antarctic marine environment Molecular evolution |
description |
Cryonotothenioidea is the main group of fishes that thrive in the extremely cold Antarctic environment, thanks to the acquisition of peculiar morphological, physiological and molecular adaptations. We have previously disclosed that IgM, the main immunoglobulin isotype in teleosts, display typical cold-adapted features. Recently, we have analyzed the gene encoding the heavy chain constant region (CH) of the IgT isotype from the Antarctic teleost Trematomus bernacchii (family Nototheniidae), characterized by the near-complete deletion of the CH2 domain. Here, we aimed to track the loss of the CH2 domain along notothenioid phylogeny and to identify its ancestral origins. To this end, we obtained the IgT gene sequences from several species belonging to the Antarctic families Nototheniidae, Bathydraconidae and Artedidraconidae. All species display a CH2 remnant of variable size, encoded by a short Cτ2 exon, which retains functional splicing sites and therefore is included in the mature transcript. We also considered representative species from the three non-Antarctic families: Eleginopsioidea (Eleginops maclovinus), Pseudaphritioidea (Pseudaphritis urvillii) and Bovichtidae (Bovichtus diacanthus and Cottoperca gobio). Even though only E. maclovinus, the sister taxa of Cryonotothenioidea, shared the partial loss of Cτ2, the other non-Antarctic notothenioid species displayed early molecular signatures of this event. These results shed light on the evolutionary path that underlies the origins of this remarkable gene structural modification. |
author2 |
Ametrano, Alessia Gerdol, Marco Vitale, Maria Greco, Samuele Oreste, Umberto Coscia, Maria Rosaria |
format |
Article in Journal/Newspaper |
author |
Ametrano, Alessia Gerdol, Marco Vitale, Maria Greco, Samuele Oreste, Umberto Coscia, Maria Rosaria |
author_facet |
Ametrano, Alessia Gerdol, Marco Vitale, Maria Greco, Samuele Oreste, Umberto Coscia, Maria Rosaria |
author_sort |
Ametrano, Alessia |
title |
The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes |
title_short |
The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes |
title_full |
The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes |
title_fullStr |
The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes |
title_full_unstemmed |
The evolutionary puzzle solution for the origins of the partial loss of the Cτ2 exon in notothenioid fishes |
title_sort |
evolutionary puzzle solution for the origins of the partial loss of the cτ2 exon in notothenioid fishes |
publishDate |
2021 |
url |
http://hdl.handle.net/11368/2993650 https://doi.org/10.1016/j.fsi.2021.05.015 https://www.sciencedirect.com/science/article/pii/S1050464821001431 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/34038801 info:eu-repo/semantics/altIdentifier/wos/WOS:000682963400001 volume:116 firstpage:124 lastpage:139 numberofpages:16 journal:FISH AND SHELLFISH IMMUNOLOGY http://hdl.handle.net/11368/2993650 doi:10.1016/j.fsi.2021.05.015 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85109519730 https://www.sciencedirect.com/science/article/pii/S1050464821001431 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.fsi.2021.05.015 |
container_title |
Fish & Shellfish Immunology |
container_volume |
116 |
container_start_page |
124 |
op_container_end_page |
139 |
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1766260461010944000 |