Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity
The advent of high throughput sequencing has permitted to investigate the genome and the transcriptome of novel non-model species with unprecedented depth. This technological advance provided a better understanding of the evolution of adaptive immune genes in gnathostomes, revealing several unexpect...
Published in: | Molecular Immunology |
---|---|
Main Authors: | , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2015
|
Subjects: | |
Online Access: | http://hdl.handle.net/11368/2858363 https://doi.org/10.1016/j.molimm.2015.09.003 |
id |
ftunitriestiris:oai:arts.units.it:11368/2858363 |
---|---|
record_format |
openpolar |
spelling |
ftunitriestiris:oai:arts.units.it:11368/2858363 2023-05-15T15:27:20+02:00 Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity Buonocore, Francesco GERDOL, MARCO Buonocore, Francesco Gerdol, Marco 2015 STAMPA http://hdl.handle.net/11368/2858363 https://doi.org/10.1016/j.molimm.2015.09.003 eng eng info:eu-repo/semantics/altIdentifier/pmid/26423359 info:eu-repo/semantics/altIdentifier/wos/WOS:000368867800019 volume:69(2016) firstpage:157 lastpage:169 numberofpages:13 journal:MOLECULAR IMMUNOLOGY http://hdl.handle.net/11368/2858363 doi:10.1016/j.molimm.2015.09.003 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84966372768 info:eu-repo/semantics/closedAccess Adaptive immunity CD4 Coelacanth Immunoglobulin Major histocompatibility complex T helper cell Molecular Biology Immunology info:eu-repo/semantics/article 2015 ftunitriestiris https://doi.org/10.1016/j.molimm.2015.09.003 2023-04-05T16:52:32Z The advent of high throughput sequencing has permitted to investigate the genome and the transcriptome of novel non-model species with unprecedented depth. This technological advance provided a better understanding of the evolution of adaptive immune genes in gnathostomes, revealing several unexpected features in different fish species which are of particular interest. In the present paper, we review the current understanding of the adaptive immune system of the coelacanth, the elephant shark and the Atlantic cod. The study of coelacanth, the only living extant of the long thought to be extinct Sarcopterygian lineage, is fundamental to bring new insights on the evolution of the immune system in higher vertebrates. Surprisingly, coelacanths are the only known jawed vertebrates to lack IgM, whereas two IgD/W loci are present. Cartilaginous fish are of great interest due to their basal position in the vertebrate tree of life; the genome of the elephant shark revealed the lack of several important immune genes related to T cell functions, which suggest the existence of a primordial set of TH1-like cells. Finally, the Atlantic cod lacks a functional major histocompatibility II complex, but balances this evolutionary loss with the expansion of specific gene families, including MHC I, Toll-like receptors and antimicrobial peptides. Overall, these data point out that several fish species present an unconventional adaptive immune system, but the loss of important immune genes is balanced by adaptive evolutionary strategies which still guarantee the establishment of an efficient immune response against the pathogens they have to fight during their life. Article in Journal/Newspaper atlantic cod Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) Molecular Immunology 69 157 169 |
institution |
Open Polar |
collection |
Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
op_collection_id |
ftunitriestiris |
language |
English |
topic |
Adaptive immunity CD4 Coelacanth Immunoglobulin Major histocompatibility complex T helper cell Molecular Biology Immunology |
spellingShingle |
Adaptive immunity CD4 Coelacanth Immunoglobulin Major histocompatibility complex T helper cell Molecular Biology Immunology Buonocore, Francesco GERDOL, MARCO Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity |
topic_facet |
Adaptive immunity CD4 Coelacanth Immunoglobulin Major histocompatibility complex T helper cell Molecular Biology Immunology |
description |
The advent of high throughput sequencing has permitted to investigate the genome and the transcriptome of novel non-model species with unprecedented depth. This technological advance provided a better understanding of the evolution of adaptive immune genes in gnathostomes, revealing several unexpected features in different fish species which are of particular interest. In the present paper, we review the current understanding of the adaptive immune system of the coelacanth, the elephant shark and the Atlantic cod. The study of coelacanth, the only living extant of the long thought to be extinct Sarcopterygian lineage, is fundamental to bring new insights on the evolution of the immune system in higher vertebrates. Surprisingly, coelacanths are the only known jawed vertebrates to lack IgM, whereas two IgD/W loci are present. Cartilaginous fish are of great interest due to their basal position in the vertebrate tree of life; the genome of the elephant shark revealed the lack of several important immune genes related to T cell functions, which suggest the existence of a primordial set of TH1-like cells. Finally, the Atlantic cod lacks a functional major histocompatibility II complex, but balances this evolutionary loss with the expansion of specific gene families, including MHC I, Toll-like receptors and antimicrobial peptides. Overall, these data point out that several fish species present an unconventional adaptive immune system, but the loss of important immune genes is balanced by adaptive evolutionary strategies which still guarantee the establishment of an efficient immune response against the pathogens they have to fight during their life. |
author2 |
Buonocore, Francesco Gerdol, Marco |
format |
Article in Journal/Newspaper |
author |
Buonocore, Francesco GERDOL, MARCO |
author_facet |
Buonocore, Francesco GERDOL, MARCO |
author_sort |
Buonocore, Francesco |
title |
Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity |
title_short |
Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity |
title_full |
Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity |
title_fullStr |
Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity |
title_full_unstemmed |
Alternative adaptive immunity strategies: Coelacanth, cod and shark immunity |
title_sort |
alternative adaptive immunity strategies: coelacanth, cod and shark immunity |
publishDate |
2015 |
url |
http://hdl.handle.net/11368/2858363 https://doi.org/10.1016/j.molimm.2015.09.003 |
genre |
atlantic cod |
genre_facet |
atlantic cod |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/26423359 info:eu-repo/semantics/altIdentifier/wos/WOS:000368867800019 volume:69(2016) firstpage:157 lastpage:169 numberofpages:13 journal:MOLECULAR IMMUNOLOGY http://hdl.handle.net/11368/2858363 doi:10.1016/j.molimm.2015.09.003 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84966372768 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.molimm.2015.09.003 |
container_title |
Molecular Immunology |
container_volume |
69 |
container_start_page |
157 |
op_container_end_page |
169 |
_version_ |
1766357776562388992 |