The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia

C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of bivalve mollusks and other invertebrates and their highly adaptive binding properties indicate them as efficient pathogen recognition molecules. Although experimental studies support this view, the mol...

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Published in:Developmental & Comparative Immunology
Main Authors: GERDOL, MARCO, PALLAVICINI, Alberto, Venier, Paola
Other Authors: Gerdol, Marco, Pallavicini, Alberto
Format: Article in Journal/Newspaper
Language:English
Published: 2015
Subjects:
C1q
Online Access:http://hdl.handle.net/11368/2833447
https://doi.org/10.1016/j.dci.2014.11.007
http://www.sciencedirect.com/science/journal/0145305X/49/1
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spelling ftunitriestiris:oai:arts.units.it:11368/2833447 2023-05-15T15:58:01+02:00 The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia GERDOL, MARCO PALLAVICINI, Alberto Venier, Paola Gerdol, Marco Venier, Paola Pallavicini, Alberto 2015 STAMPA http://hdl.handle.net/11368/2833447 https://doi.org/10.1016/j.dci.2014.11.007 http://www.sciencedirect.com/science/journal/0145305X/49/1 eng eng info:eu-repo/semantics/altIdentifier/pmid/25445912 info:eu-repo/semantics/altIdentifier/wos/WOS:000348889800008 volume:49 issue:1 firstpage:59 lastpage:71 numberofpages:13 journal:DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY http://hdl.handle.net/11368/2833447 doi:10.1016/j.dci.2014.11.007 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84912059102 http://www.sciencedirect.com/science/journal/0145305X/49/1 info:eu-repo/semantics/openAccess Bivalvia C1q Crassostrea giga Innate immunity Lectin-like Developmental Biology Immunology info:eu-repo/semantics/article 2015 ftunitriestiris https://doi.org/10.1016/j.dci.2014.11.007 2023-04-09T06:12:20Z C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of bivalve mollusks and other invertebrates and their highly adaptive binding properties indicate them as efficient pathogen recognition molecules. Although experimental studies support this view, the molecular data available at the present time are not sufficient to fully explain the great molecular diversification of this family, present in bivalves with hundreds of C1q coding genes. Taking advantage of the fully sequenced genome of the Pacific oyster Crassostrea gigas and more than 100 transcriptomic datasets, we: (i) re-annotated the oyster C1qDC loci, thus identifying the correct genomic organization of 337 C1qDC genes, (ii) explored the expression pattern of oyster C1qDC genes in diverse developmental stages and adult tissues of unchallenged and experimentally treated animals; (iii) investigated the expansion of the C1qDC gene family in all major bivalve subclasses.Overall, we provide a broad description of the functionally relevant features of oyster C1qDC genes, their comparative expression levels and new evidence confirming that a gene family expansion event has occurred during the course of Bivalve evolution, leading to the diversification of hundreds of different C1qDC genes in both the Pteriomorphia and Heterodonta subclasses. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) Pacific Developmental & Comparative Immunology 49 1 59 71
institution Open Polar
collection Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste)
op_collection_id ftunitriestiris
language English
topic Bivalvia
C1q
Crassostrea giga
Innate immunity
Lectin-like
Developmental Biology
Immunology
spellingShingle Bivalvia
C1q
Crassostrea giga
Innate immunity
Lectin-like
Developmental Biology
Immunology
GERDOL, MARCO
PALLAVICINI, Alberto
Venier, Paola
The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia
topic_facet Bivalvia
C1q
Crassostrea giga
Innate immunity
Lectin-like
Developmental Biology
Immunology
description C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of bivalve mollusks and other invertebrates and their highly adaptive binding properties indicate them as efficient pathogen recognition molecules. Although experimental studies support this view, the molecular data available at the present time are not sufficient to fully explain the great molecular diversification of this family, present in bivalves with hundreds of C1q coding genes. Taking advantage of the fully sequenced genome of the Pacific oyster Crassostrea gigas and more than 100 transcriptomic datasets, we: (i) re-annotated the oyster C1qDC loci, thus identifying the correct genomic organization of 337 C1qDC genes, (ii) explored the expression pattern of oyster C1qDC genes in diverse developmental stages and adult tissues of unchallenged and experimentally treated animals; (iii) investigated the expansion of the C1qDC gene family in all major bivalve subclasses.Overall, we provide a broad description of the functionally relevant features of oyster C1qDC genes, their comparative expression levels and new evidence confirming that a gene family expansion event has occurred during the course of Bivalve evolution, leading to the diversification of hundreds of different C1qDC genes in both the Pteriomorphia and Heterodonta subclasses.
author2 Gerdol, Marco
Venier, Paola
Pallavicini, Alberto
format Article in Journal/Newspaper
author GERDOL, MARCO
PALLAVICINI, Alberto
Venier, Paola
author_facet GERDOL, MARCO
PALLAVICINI, Alberto
Venier, Paola
author_sort GERDOL, MARCO
title The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia
title_short The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia
title_full The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia
title_fullStr The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia
title_full_unstemmed The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia
title_sort genome of the pacific oyster crassostrea gigas brings new insights on the massive expansion of the c1q gene family in bivalvia
publishDate 2015
url http://hdl.handle.net/11368/2833447
https://doi.org/10.1016/j.dci.2014.11.007
http://www.sciencedirect.com/science/journal/0145305X/49/1
geographic Pacific
geographic_facet Pacific
genre Crassostrea gigas
Pacific oyster
genre_facet Crassostrea gigas
Pacific oyster
op_relation info:eu-repo/semantics/altIdentifier/pmid/25445912
info:eu-repo/semantics/altIdentifier/wos/WOS:000348889800008
volume:49
issue:1
firstpage:59
lastpage:71
numberofpages:13
journal:DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
http://hdl.handle.net/11368/2833447
doi:10.1016/j.dci.2014.11.007
info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84912059102
http://www.sciencedirect.com/science/journal/0145305X/49/1
op_rights info:eu-repo/semantics/openAccess
op_doi https://doi.org/10.1016/j.dci.2014.11.007
container_title Developmental & Comparative Immunology
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