The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia
C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of bivalve mollusks and other invertebrates and their highly adaptive binding properties indicate them as efficient pathogen recognition molecules. Although experimental studies support this view, the mol...
Published in: | Developmental & Comparative Immunology |
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Online Access: | http://hdl.handle.net/11368/2833447 https://doi.org/10.1016/j.dci.2014.11.007 http://www.sciencedirect.com/science/journal/0145305X/49/1 |
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ftunitriestiris:oai:arts.units.it:11368/2833447 2023-05-15T15:58:01+02:00 The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia GERDOL, MARCO PALLAVICINI, Alberto Venier, Paola Gerdol, Marco Venier, Paola Pallavicini, Alberto 2015 STAMPA http://hdl.handle.net/11368/2833447 https://doi.org/10.1016/j.dci.2014.11.007 http://www.sciencedirect.com/science/journal/0145305X/49/1 eng eng info:eu-repo/semantics/altIdentifier/pmid/25445912 info:eu-repo/semantics/altIdentifier/wos/WOS:000348889800008 volume:49 issue:1 firstpage:59 lastpage:71 numberofpages:13 journal:DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY http://hdl.handle.net/11368/2833447 doi:10.1016/j.dci.2014.11.007 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84912059102 http://www.sciencedirect.com/science/journal/0145305X/49/1 info:eu-repo/semantics/openAccess Bivalvia C1q Crassostrea giga Innate immunity Lectin-like Developmental Biology Immunology info:eu-repo/semantics/article 2015 ftunitriestiris https://doi.org/10.1016/j.dci.2014.11.007 2023-04-09T06:12:20Z C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of bivalve mollusks and other invertebrates and their highly adaptive binding properties indicate them as efficient pathogen recognition molecules. Although experimental studies support this view, the molecular data available at the present time are not sufficient to fully explain the great molecular diversification of this family, present in bivalves with hundreds of C1q coding genes. Taking advantage of the fully sequenced genome of the Pacific oyster Crassostrea gigas and more than 100 transcriptomic datasets, we: (i) re-annotated the oyster C1qDC loci, thus identifying the correct genomic organization of 337 C1qDC genes, (ii) explored the expression pattern of oyster C1qDC genes in diverse developmental stages and adult tissues of unchallenged and experimentally treated animals; (iii) investigated the expansion of the C1qDC gene family in all major bivalve subclasses.Overall, we provide a broad description of the functionally relevant features of oyster C1qDC genes, their comparative expression levels and new evidence confirming that a gene family expansion event has occurred during the course of Bivalve evolution, leading to the diversification of hundreds of different C1qDC genes in both the Pteriomorphia and Heterodonta subclasses. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) Pacific Developmental & Comparative Immunology 49 1 59 71 |
institution |
Open Polar |
collection |
Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
op_collection_id |
ftunitriestiris |
language |
English |
topic |
Bivalvia C1q Crassostrea giga Innate immunity Lectin-like Developmental Biology Immunology |
spellingShingle |
Bivalvia C1q Crassostrea giga Innate immunity Lectin-like Developmental Biology Immunology GERDOL, MARCO PALLAVICINI, Alberto Venier, Paola The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia |
topic_facet |
Bivalvia C1q Crassostrea giga Innate immunity Lectin-like Developmental Biology Immunology |
description |
C1q domain-containing (C1qDC) proteins are regarded as important players in the innate immunity of bivalve mollusks and other invertebrates and their highly adaptive binding properties indicate them as efficient pathogen recognition molecules. Although experimental studies support this view, the molecular data available at the present time are not sufficient to fully explain the great molecular diversification of this family, present in bivalves with hundreds of C1q coding genes. Taking advantage of the fully sequenced genome of the Pacific oyster Crassostrea gigas and more than 100 transcriptomic datasets, we: (i) re-annotated the oyster C1qDC loci, thus identifying the correct genomic organization of 337 C1qDC genes, (ii) explored the expression pattern of oyster C1qDC genes in diverse developmental stages and adult tissues of unchallenged and experimentally treated animals; (iii) investigated the expansion of the C1qDC gene family in all major bivalve subclasses.Overall, we provide a broad description of the functionally relevant features of oyster C1qDC genes, their comparative expression levels and new evidence confirming that a gene family expansion event has occurred during the course of Bivalve evolution, leading to the diversification of hundreds of different C1qDC genes in both the Pteriomorphia and Heterodonta subclasses. |
author2 |
Gerdol, Marco Venier, Paola Pallavicini, Alberto |
format |
Article in Journal/Newspaper |
author |
GERDOL, MARCO PALLAVICINI, Alberto Venier, Paola |
author_facet |
GERDOL, MARCO PALLAVICINI, Alberto Venier, Paola |
author_sort |
GERDOL, MARCO |
title |
The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia |
title_short |
The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia |
title_full |
The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia |
title_fullStr |
The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia |
title_full_unstemmed |
The genome of the Pacific oyster Crassostrea gigas brings new insights on the massive expansion of the C1q gene family in Bivalvia |
title_sort |
genome of the pacific oyster crassostrea gigas brings new insights on the massive expansion of the c1q gene family in bivalvia |
publishDate |
2015 |
url |
http://hdl.handle.net/11368/2833447 https://doi.org/10.1016/j.dci.2014.11.007 http://www.sciencedirect.com/science/journal/0145305X/49/1 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/25445912 info:eu-repo/semantics/altIdentifier/wos/WOS:000348889800008 volume:49 issue:1 firstpage:59 lastpage:71 numberofpages:13 journal:DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY http://hdl.handle.net/11368/2833447 doi:10.1016/j.dci.2014.11.007 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84912059102 http://www.sciencedirect.com/science/journal/0145305X/49/1 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1016/j.dci.2014.11.007 |
container_title |
Developmental & Comparative Immunology |
container_volume |
49 |
container_issue |
1 |
container_start_page |
59 |
op_container_end_page |
71 |
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1766393747108528128 |