The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains.
The cathelicidin family of host defence peptides is regarded as an important component of the host innate immune system. Its members have been found in mammals, birds, primitive vertebrate Atlantic hagfish and, most recently, also in ray-finned fish such as rainbow trout and Atlantic salmon. By usin...
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ftunitriestiris:oai:arts.units.it:11368/2278903 2023-05-15T15:32:26+02:00 The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. SCOCCHI, MARCO SALGARO R BOCIEK K PALLAVICINI, Alberto GENNARO, RENATO Scocchi, Marco Pallavicini, Alberto Salgaro, R Bociek, K Gennaro, Renato 2009 STAMPA http://hdl.handle.net/11368/2278903 http://www.sciencedirect.com/science/article/pii/S1096495909000116 eng eng info:eu-repo/semantics/altIdentifier/wos/WOS:000264616400011 volume:152(4) firstpage:376 lastpage:381 journal:COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY http://hdl.handle.net/11368/2278903 10.1016/j.cbpb.2009.01.003, info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-60649099532 http://www.sciencedirect.com/science/article/pii/S1096495909000116 Antimicrobial peptide Cathelicidin Gene family Host defence peptide Innate immunity Salmonidae info:eu-repo/semantics/article 2009 ftunitriestiris 2023-04-09T06:16:58Z The cathelicidin family of host defence peptides is regarded as an important component of the host innate immune system. Its members have been found in mammals, birds, primitive vertebrate Atlantic hagfish and, most recently, also in ray-finned fish such as rainbow trout and Atlantic salmon. By using genomic PCR amplifications and RT-PCR tissue analyses we have here investigated and characterized the cathelicidin genefamily in three salmonids: brown trout (Salmo trutta fario), brook trout (Salvelinus fontinalis) and grayling (Thymallus thymallus). One or two different genes were found in each species coding for almost identical cathelin-like domains and largely varied cationic C-terminal regions. Multiple alignment of the amino acid sequences let us recognize two distinctive hallmarks of these peptides: the presence of a high number of serine and glycine residues, which may collocate them in a new class of antimicrobial peptides, and of the six-amino-acid repeated sequence RPGGGS detected in a variable number of copies among different cathelicidins. The high variation in length and sequence of this region suggests the existence of a genetically unstable region similar to that found in some mammalian cathelicidins. Article in Journal/Newspaper Atlantic salmon Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
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Open Polar |
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Università degli studi di Trieste: ArTS (Archivio della ricerca di Trieste) |
op_collection_id |
ftunitriestiris |
language |
English |
topic |
Antimicrobial peptide Cathelicidin Gene family Host defence peptide Innate immunity Salmonidae |
spellingShingle |
Antimicrobial peptide Cathelicidin Gene family Host defence peptide Innate immunity Salmonidae SCOCCHI, MARCO SALGARO R BOCIEK K PALLAVICINI, Alberto GENNARO, RENATO The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. |
topic_facet |
Antimicrobial peptide Cathelicidin Gene family Host defence peptide Innate immunity Salmonidae |
description |
The cathelicidin family of host defence peptides is regarded as an important component of the host innate immune system. Its members have been found in mammals, birds, primitive vertebrate Atlantic hagfish and, most recently, also in ray-finned fish such as rainbow trout and Atlantic salmon. By using genomic PCR amplifications and RT-PCR tissue analyses we have here investigated and characterized the cathelicidin genefamily in three salmonids: brown trout (Salmo trutta fario), brook trout (Salvelinus fontinalis) and grayling (Thymallus thymallus). One or two different genes were found in each species coding for almost identical cathelin-like domains and largely varied cationic C-terminal regions. Multiple alignment of the amino acid sequences let us recognize two distinctive hallmarks of these peptides: the presence of a high number of serine and glycine residues, which may collocate them in a new class of antimicrobial peptides, and of the six-amino-acid repeated sequence RPGGGS detected in a variable number of copies among different cathelicidins. The high variation in length and sequence of this region suggests the existence of a genetically unstable region similar to that found in some mammalian cathelicidins. |
author2 |
Scocchi, Marco Pallavicini, Alberto Salgaro, R Bociek, K Gennaro, Renato |
format |
Article in Journal/Newspaper |
author |
SCOCCHI, MARCO SALGARO R BOCIEK K PALLAVICINI, Alberto GENNARO, RENATO |
author_facet |
SCOCCHI, MARCO SALGARO R BOCIEK K PALLAVICINI, Alberto GENNARO, RENATO |
author_sort |
SCOCCHI, MARCO |
title |
The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. |
title_short |
The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. |
title_full |
The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. |
title_fullStr |
The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. |
title_full_unstemmed |
The salmonid cathelicidins: a gene family with highly varied C-terminal antimicrobial domains. |
title_sort |
salmonid cathelicidins: a gene family with highly varied c-terminal antimicrobial domains. |
publishDate |
2009 |
url |
http://hdl.handle.net/11368/2278903 http://www.sciencedirect.com/science/article/pii/S1096495909000116 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
info:eu-repo/semantics/altIdentifier/wos/WOS:000264616400011 volume:152(4) firstpage:376 lastpage:381 journal:COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY. PART B, BIOCHEMISTRY & MOLECULAR BIOLOGY http://hdl.handle.net/11368/2278903 10.1016/j.cbpb.2009.01.003, info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-60649099532 http://www.sciencedirect.com/science/article/pii/S1096495909000116 |
_version_ |
1766362938998784000 |