TUMOUR PATHOLOGY PREDICTS MICROSATELLITE INSTABILITY IN A POPULATION-BASED SERIES OF COLORECTAL CANCER CASES

• Published in: Clinical & Investigative Medicine
• Main Authors: Hyde, A J, Fontaine, D, Green, R C, Simms, M, Parfrey, P S, Younghusband, H B
• Format: Article in Journal/Newspaper
• Language: English
• Published: Canadian Society for Clinical Investigation 2008
• Subjects: Lynch; Newfoundland
• Online Access: https://cimonline.ca/index.php/cim/article/view/4807; https://doi.org/10.25011/cim.v31i4.4807

Background: Lynch Syndrome is an autosomal dominant trait that accounts forapproximately 3% of all cases of colorectal cancer (CRC). It is caused by mutations in DNA mismatch repair (MMR) genes, most commonly MLH1 or MSH2. These MMR defects cause high levels of microsatellite instability (MSI-H) in...