Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals
The molecular evolution of the mammalian heater protein UCP1 is a powerful biomarker to understand thermoregulatory strategies during species radiation into extreme climates, such as aquatic life with high thermal conductivity. While fully aquatic mammals lost UCP1, most semiaquatic seals display in...
Published in: | Molecular Biology and Evolution |
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Language: | English |
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Oxford University Press (OUP)
2024
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Online Access: | http://hdl.handle.net/2078.1/291240 https://doi.org/10.1093/molbev/msae075 |
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ftunistlouisbrus:oai:dial.uclouvain.be:boreal:291240 2024-09-30T14:34:22+00:00 Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals Gaudry, Michael J Khudyakov, Jane Pirard, Laura Debier, Cathy Crocker, Daniel Crichton, Paul G Jastroch, Martin Wilson, Melissa UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies 2024 http://hdl.handle.net/2078.1/291240 https://doi.org/10.1093/molbev/msae075 eng eng Oxford University Press (OUP) boreal:291240 http://hdl.handle.net/2078.1/291240 doi:10.1093/molbev/msae075 urn:ISSN:0737-4038 urn:EISSN:1537-1719 info:eu-repo/semantics/openAccess Molecular Biology and Evolution, Vol. 41, no.4, p. None (2024) brown adipose tissue nonshivering thermogenesis pinniped pseudogene UCP1 info:eu-repo/semantics/article 2024 ftunistlouisbrus https://doi.org/10.1093/molbev/msae075 2024-09-17T14:13:31Z The molecular evolution of the mammalian heater protein UCP1 is a powerful biomarker to understand thermoregulatory strategies during species radiation into extreme climates, such as aquatic life with high thermal conductivity. While fully aquatic mammals lost UCP1, most semiaquatic seals display intact UCP1 genes, apart from large elephant seals. Here, we show that UCP1 thermogenic activity of the small-bodied harbor seal is equally potent compared to terrestrial orthologs, emphasizing its importance for neonatal survival on land. In contrast, elephant seal UCP1 does not display thermogenic activity, not even when translating a repaired or a recently highlighted truncated version. Thus, the thermogenic benefits for neonatal survival during terrestrial birth in semiaquatic pinnipeds maintained evolutionary selection pressure on UCP1 function and were only outweighed by extreme body sizes among elephant seals, fully eliminating UCP1-dependent thermogenesis. © The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Article in Journal/Newspaper Elephant Seal Elephant Seals harbor seal DIAL@USL-B (Université Saint-Louis, Bruxelles) Molecular Biology and Evolution 41 4 |
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Open Polar |
collection |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
op_collection_id |
ftunistlouisbrus |
language |
English |
topic |
brown adipose tissue nonshivering thermogenesis pinniped pseudogene UCP1 |
spellingShingle |
brown adipose tissue nonshivering thermogenesis pinniped pseudogene UCP1 Gaudry, Michael J Khudyakov, Jane Pirard, Laura Debier, Cathy Crocker, Daniel Crichton, Paul G Jastroch, Martin Wilson, Melissa Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals |
topic_facet |
brown adipose tissue nonshivering thermogenesis pinniped pseudogene UCP1 |
description |
The molecular evolution of the mammalian heater protein UCP1 is a powerful biomarker to understand thermoregulatory strategies during species radiation into extreme climates, such as aquatic life with high thermal conductivity. While fully aquatic mammals lost UCP1, most semiaquatic seals display intact UCP1 genes, apart from large elephant seals. Here, we show that UCP1 thermogenic activity of the small-bodied harbor seal is equally potent compared to terrestrial orthologs, emphasizing its importance for neonatal survival on land. In contrast, elephant seal UCP1 does not display thermogenic activity, not even when translating a repaired or a recently highlighted truncated version. Thus, the thermogenic benefits for neonatal survival during terrestrial birth in semiaquatic pinnipeds maintained evolutionary selection pressure on UCP1 function and were only outweighed by extreme body sizes among elephant seals, fully eliminating UCP1-dependent thermogenesis. © The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
author2 |
UCL - SSH/IACS - Institute of Analysis of Change in Contemporary and Historical Societies |
format |
Article in Journal/Newspaper |
author |
Gaudry, Michael J Khudyakov, Jane Pirard, Laura Debier, Cathy Crocker, Daniel Crichton, Paul G Jastroch, Martin Wilson, Melissa |
author_facet |
Gaudry, Michael J Khudyakov, Jane Pirard, Laura Debier, Cathy Crocker, Daniel Crichton, Paul G Jastroch, Martin Wilson, Melissa |
author_sort |
Gaudry, Michael J |
title |
Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals |
title_short |
Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals |
title_full |
Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals |
title_fullStr |
Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals |
title_full_unstemmed |
Terrestrial Birth and Body Size Tune UCP1 Functionality in Seals |
title_sort |
terrestrial birth and body size tune ucp1 functionality in seals |
publisher |
Oxford University Press (OUP) |
publishDate |
2024 |
url |
http://hdl.handle.net/2078.1/291240 https://doi.org/10.1093/molbev/msae075 |
genre |
Elephant Seal Elephant Seals harbor seal |
genre_facet |
Elephant Seal Elephant Seals harbor seal |
op_source |
Molecular Biology and Evolution, Vol. 41, no.4, p. None (2024) |
op_relation |
boreal:291240 http://hdl.handle.net/2078.1/291240 doi:10.1093/molbev/msae075 urn:ISSN:0737-4038 urn:EISSN:1537-1719 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1093/molbev/msae075 |
container_title |
Molecular Biology and Evolution |
container_volume |
41 |
container_issue |
4 |
_version_ |
1811638008817909760 |