Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND).
BACKGROUND: Intermittent androgen deprivation (IAD) has received increasing attention; however, the current literature is still limited, especially in nonmetastatic prostate cancer (PCa), and the relative efficacy and safety benefits of IAD versus continuous androgen deprivation (CAD) remain unclear...
Published in: | European Urology |
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Format: | Article in Journal/Newspaper |
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Elsevier BV
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Online Access: | http://hdl.handle.net/2078.1/172724 https://doi.org/10.1016/j.eururo.2015.10.007 |
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ftunistlouisbrus:oai:dial.uclouvain.be:boreal:172724 2024-05-12T08:06:01+00:00 Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND). Schulman, Claude Cornel, Erik Matveev, Vsevolod Tammela, Teuvo L Schraml, Jan Bensadoun, Henri Warnack, Wolfgang Persad, Raj Salagierski, Marek Gómez Veiga, Francisco Baskin-Bey, Edwina López, Beatriz Tombal, Bertrand UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation UCL - (SLuc) Service d'urologie 2016 http://hdl.handle.net/2078.1/172724 https://doi.org/10.1016/j.eururo.2015.10.007 eng eng Elsevier BV boreal:172724 http://hdl.handle.net/2078.1/172724 doi:10.1016/j.eururo.2015.10.007 info:pmid/26520703 urn:ISSN:0302-2838 urn:EISSN:1421-993X info:eu-repo/semantics/restrictedAccess European Urology, Vol. 69, no.4, p. 720-727 (2016) Androgen deprivation Continuous androgen deprivation Prostate cancer Nonmetastatic Prostate-specific antigen progression Testosterone Intermittent androgen deprivation info:eu-repo/semantics/article 2016 ftunistlouisbrus https://doi.org/10.1016/j.eururo.2015.10.007 2024-04-18T17:42:26Z BACKGROUND: Intermittent androgen deprivation (IAD) has received increasing attention; however, the current literature is still limited, especially in nonmetastatic prostate cancer (PCa), and the relative efficacy and safety benefits of IAD versus continuous androgen deprivation (CAD) remain unclear. OBJECTIVE: To add to the knowledge base regarding efficacy and potential benefits, including reduced side effects and improved quality of life (QoL), of IAD versus CAD in patients with nonmetastatic relapsing or locally advanced PCa. DESIGN, SETTING, AND PARTICIPANTS: A 42-mo phase 3b open-label randomised study in 933 patients from 20 European countries. INTERVENTION: Following a 6-mo induction with leuprorelin acetate (Eligard) 22.5mg 3-mo depot, patients were randomised to CAD or IAD with leuprorelin for 36 mo. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary end point was time to prostate-specific antigen (PSA) progression while receiving luteinising hormone-releasing hormone agonist, defined as three consecutive increasing PSA values ≥ 4 ng/ml ≥ 2 wk apart. Secondary end points included PSA progression-free survival (PFS), overall survival (OS), testosterone levels, performance status, and QoL. RESULTS AND LIMITATIONS: A total of 933 patients entered the induction phase; 701 were randomised. The median number of injections administered after randomisation was 12 (range: 1-12) for the CAD group and 3 (range: 1-10) for the IAD group. There were no statistically significant or clinically relevant differences between the groups for time to PSA progression, PSA PFS, OS, mean PSA levels over time, or QoL. A similar number of adverse events was observed in each group; the most common were hot flushes and hypertension. Study limitations include the open-label design and absence of formal testosterone recovery assessment. CONCLUSIONS: IAD and CAD demonstrated similar efficacy, tolerability, and QoL in men with nonmetastatic PCa. The principal benefit of IAD compared with CAD is a potential cost reduction ... Article in Journal/Newspaper Iceland DIAL@USL-B (Université Saint-Louis, Bruxelles) European Urology 69 4 720 727 |
institution |
Open Polar |
collection |
DIAL@USL-B (Université Saint-Louis, Bruxelles) |
op_collection_id |
ftunistlouisbrus |
language |
English |
topic |
Androgen deprivation Continuous androgen deprivation Prostate cancer Nonmetastatic Prostate-specific antigen progression Testosterone Intermittent androgen deprivation |
spellingShingle |
Androgen deprivation Continuous androgen deprivation Prostate cancer Nonmetastatic Prostate-specific antigen progression Testosterone Intermittent androgen deprivation Schulman, Claude Cornel, Erik Matveev, Vsevolod Tammela, Teuvo L Schraml, Jan Bensadoun, Henri Warnack, Wolfgang Persad, Raj Salagierski, Marek Gómez Veiga, Francisco Baskin-Bey, Edwina López, Beatriz Tombal, Bertrand Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND). |
topic_facet |
Androgen deprivation Continuous androgen deprivation Prostate cancer Nonmetastatic Prostate-specific antigen progression Testosterone Intermittent androgen deprivation |
description |
BACKGROUND: Intermittent androgen deprivation (IAD) has received increasing attention; however, the current literature is still limited, especially in nonmetastatic prostate cancer (PCa), and the relative efficacy and safety benefits of IAD versus continuous androgen deprivation (CAD) remain unclear. OBJECTIVE: To add to the knowledge base regarding efficacy and potential benefits, including reduced side effects and improved quality of life (QoL), of IAD versus CAD in patients with nonmetastatic relapsing or locally advanced PCa. DESIGN, SETTING, AND PARTICIPANTS: A 42-mo phase 3b open-label randomised study in 933 patients from 20 European countries. INTERVENTION: Following a 6-mo induction with leuprorelin acetate (Eligard) 22.5mg 3-mo depot, patients were randomised to CAD or IAD with leuprorelin for 36 mo. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary end point was time to prostate-specific antigen (PSA) progression while receiving luteinising hormone-releasing hormone agonist, defined as three consecutive increasing PSA values ≥ 4 ng/ml ≥ 2 wk apart. Secondary end points included PSA progression-free survival (PFS), overall survival (OS), testosterone levels, performance status, and QoL. RESULTS AND LIMITATIONS: A total of 933 patients entered the induction phase; 701 were randomised. The median number of injections administered after randomisation was 12 (range: 1-12) for the CAD group and 3 (range: 1-10) for the IAD group. There were no statistically significant or clinically relevant differences between the groups for time to PSA progression, PSA PFS, OS, mean PSA levels over time, or QoL. A similar number of adverse events was observed in each group; the most common were hot flushes and hypertension. Study limitations include the open-label design and absence of formal testosterone recovery assessment. CONCLUSIONS: IAD and CAD demonstrated similar efficacy, tolerability, and QoL in men with nonmetastatic PCa. The principal benefit of IAD compared with CAD is a potential cost reduction ... |
author2 |
UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation UCL - (SLuc) Service d'urologie |
format |
Article in Journal/Newspaper |
author |
Schulman, Claude Cornel, Erik Matveev, Vsevolod Tammela, Teuvo L Schraml, Jan Bensadoun, Henri Warnack, Wolfgang Persad, Raj Salagierski, Marek Gómez Veiga, Francisco Baskin-Bey, Edwina López, Beatriz Tombal, Bertrand |
author_facet |
Schulman, Claude Cornel, Erik Matveev, Vsevolod Tammela, Teuvo L Schraml, Jan Bensadoun, Henri Warnack, Wolfgang Persad, Raj Salagierski, Marek Gómez Veiga, Francisco Baskin-Bey, Edwina López, Beatriz Tombal, Bertrand |
author_sort |
Schulman, Claude |
title |
Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND). |
title_short |
Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND). |
title_full |
Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND). |
title_fullStr |
Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND). |
title_full_unstemmed |
Intermittent Versus Continuous Androgen Deprivation Therapy in Patients with Relapsing or Locally Advanced Prostate Cancer: A Phase 3b Randomised Study (ICELAND). |
title_sort |
intermittent versus continuous androgen deprivation therapy in patients with relapsing or locally advanced prostate cancer: a phase 3b randomised study (iceland). |
publisher |
Elsevier BV |
publishDate |
2016 |
url |
http://hdl.handle.net/2078.1/172724 https://doi.org/10.1016/j.eururo.2015.10.007 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
European Urology, Vol. 69, no.4, p. 720-727 (2016) |
op_relation |
boreal:172724 http://hdl.handle.net/2078.1/172724 doi:10.1016/j.eururo.2015.10.007 info:pmid/26520703 urn:ISSN:0302-2838 urn:EISSN:1421-993X |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.eururo.2015.10.007 |
container_title |
European Urology |
container_volume |
69 |
container_issue |
4 |
container_start_page |
720 |
op_container_end_page |
727 |
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1798848424646279168 |