Abolition of peroxiredoxin-5 mitochondrial targeting during canid evolution.

• Published in: PLoS ONE
• Main Authors: Van Der Eecken, Valérie, Clippe, André, Dekoninck, Sophie, Goemaere, Julie, Walbrecq, Geoffroy, Van Veldhoven, Paul, Knoops, Bernard
• Other Authors: UCL - SST/ISV - Institut des sciences de la vie
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science 2013
• Subjects: Darby; Elephant Seal
• Online Access: http://hdl.handle.net/2078.1/133735; https://doi.org/10.1371/journal.pone.0072844

In human, the subcellular targeting of peroxiredoxin-5 (PRDX5), a thioredoxin peroxidase, is dependent on the use of multiple alternative transcription start sites and two alternative in-frame translation initiation sites, which determine whether or not the region encoding a mitochondrial targeting...