Reconciling migration models to the Americas with the variation of North American native mitogenomes
In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo-Aleut and northern Na-Dene speakers, revealed that th...
Published in: | Proceedings of the National Academy of Sciences |
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Online Access: | http://hdl.handle.net/11391/1216690 https://doi.org/10.1073/pnas.1306290110 |
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ftuniperugiairis:oai:research.unipg.it:11391/1216690 2024-04-14T08:00:34+00:00 Reconciling migration models to the Americas with the variation of North American native mitogenomes ACHILLI, Alessandro LANCIONI, HOVIRAG Perego UA Olivieri A Gandini F Hooshiar Kashani B Battaglia V Grugni V Angerhofer N Rogers MP Herrera RJ Woodward SR Labuda D Smith DG Cybulski JS Semino O Malhi RS Torroni A. Achilli, Alessandro Perego, Ua Lancioni, Hovirag Olivieri, A Gandini, F Hooshiar Kashani, B Battaglia, V Grugni, V Angerhofer, N Rogers, Mp Herrera, Rj Woodward, Sr Labuda, D Smith, Dg Cybulski, J Semino, O Malhi, R Torroni, A. 2013 STAMPA http://hdl.handle.net/11391/1216690 https://doi.org/10.1073/pnas.1306290110 eng eng info:eu-repo/semantics/altIdentifier/pmid/23940335 info:eu-repo/semantics/altIdentifier/wos/WOS:000323564600051 volume:110 issue:35 firstpage:14308 lastpage:14313 numberofpages:6 journal:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA http://hdl.handle.net/11391/1216690 doi:10.1073/pnas.1306290110 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84883332476 mtDNA Haplogroup Native North America info:eu-repo/semantics/article 2013 ftuniperugiairis https://doi.org/10.1073/pnas.1306290110 2024-03-21T15:50:13Z In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo-Aleut and northern Na-Dene speakers, revealed that this haplogroup arose in North America ∼11-13 ka from one of the founder Paleo-Indian B2 mitogenomes. In contrast, haplogroup A2a, which is typical of Eskimo-Aleuts and Na-Dene, but also present in the easternmost Siberian groups, originated only 4-7 ka in Alaska, led to the first Paleo-Eskimo settlement of northern Canada and Greenland, and contributed to the formation of the Na-Dene gene pool. However, mitogenomes also show that Amerindians from northern North America, without any distinction between Na-Dene and non-Na-Dene, were heavily affected by an additional and distinctive Beringian genetic input. In conclusion, most mtDNA variation (along the double-continent) stems from the first wave from Beringia, which followed the Pacific coastal route. This was accompanied or followed by a second inland migratory event, marked by haplogroups X2a and C4c, which affected all Amerindian groups of Northern North America. Much later, the ancestral A2a carriers spread from Alaska, undertaking both a westward migration to Asia and an eastward expansion into the circumpolar regions of Canada. Thus, the first American founders left the greatest genetic mark but the original maternal makeup of North American Natives was subsequently reshaped by additional streams of gene flow and local population dynamics, making a three-wave view too simplistic. Article in Journal/Newspaper aleut eskimo* Eskimo–Aleut Greenland Paleo-Eskimo Alaska Beringia IRIS Università degli Studi di Perugia Canada Greenland Indian Pacific Proceedings of the National Academy of Sciences 110 35 14308 14313 |
institution |
Open Polar |
collection |
IRIS Università degli Studi di Perugia |
op_collection_id |
ftuniperugiairis |
language |
English |
topic |
mtDNA Haplogroup Native North America |
spellingShingle |
mtDNA Haplogroup Native North America ACHILLI, Alessandro LANCIONI, HOVIRAG Perego UA Olivieri A Gandini F Hooshiar Kashani B Battaglia V Grugni V Angerhofer N Rogers MP Herrera RJ Woodward SR Labuda D Smith DG Cybulski JS Semino O Malhi RS Torroni A. Reconciling migration models to the Americas with the variation of North American native mitogenomes |
topic_facet |
mtDNA Haplogroup Native North America |
description |
In this study we evaluated migration models to the Americas by using the information contained in native mitochondrial genomes (mitogenomes) from North America. Molecular and phylogeographic analyses of B2a mitogenomes, which are absent in Eskimo-Aleut and northern Na-Dene speakers, revealed that this haplogroup arose in North America ∼11-13 ka from one of the founder Paleo-Indian B2 mitogenomes. In contrast, haplogroup A2a, which is typical of Eskimo-Aleuts and Na-Dene, but also present in the easternmost Siberian groups, originated only 4-7 ka in Alaska, led to the first Paleo-Eskimo settlement of northern Canada and Greenland, and contributed to the formation of the Na-Dene gene pool. However, mitogenomes also show that Amerindians from northern North America, without any distinction between Na-Dene and non-Na-Dene, were heavily affected by an additional and distinctive Beringian genetic input. In conclusion, most mtDNA variation (along the double-continent) stems from the first wave from Beringia, which followed the Pacific coastal route. This was accompanied or followed by a second inland migratory event, marked by haplogroups X2a and C4c, which affected all Amerindian groups of Northern North America. Much later, the ancestral A2a carriers spread from Alaska, undertaking both a westward migration to Asia and an eastward expansion into the circumpolar regions of Canada. Thus, the first American founders left the greatest genetic mark but the original maternal makeup of North American Natives was subsequently reshaped by additional streams of gene flow and local population dynamics, making a three-wave view too simplistic. |
author2 |
Achilli, Alessandro Perego, Ua Lancioni, Hovirag Olivieri, A Gandini, F Hooshiar Kashani, B Battaglia, V Grugni, V Angerhofer, N Rogers, Mp Herrera, Rj Woodward, Sr Labuda, D Smith, Dg Cybulski, J Semino, O Malhi, R Torroni, A. |
format |
Article in Journal/Newspaper |
author |
ACHILLI, Alessandro LANCIONI, HOVIRAG Perego UA Olivieri A Gandini F Hooshiar Kashani B Battaglia V Grugni V Angerhofer N Rogers MP Herrera RJ Woodward SR Labuda D Smith DG Cybulski JS Semino O Malhi RS Torroni A. |
author_facet |
ACHILLI, Alessandro LANCIONI, HOVIRAG Perego UA Olivieri A Gandini F Hooshiar Kashani B Battaglia V Grugni V Angerhofer N Rogers MP Herrera RJ Woodward SR Labuda D Smith DG Cybulski JS Semino O Malhi RS Torroni A. |
author_sort |
ACHILLI, Alessandro |
title |
Reconciling migration models to the Americas with the variation of North American native mitogenomes |
title_short |
Reconciling migration models to the Americas with the variation of North American native mitogenomes |
title_full |
Reconciling migration models to the Americas with the variation of North American native mitogenomes |
title_fullStr |
Reconciling migration models to the Americas with the variation of North American native mitogenomes |
title_full_unstemmed |
Reconciling migration models to the Americas with the variation of North American native mitogenomes |
title_sort |
reconciling migration models to the americas with the variation of north american native mitogenomes |
publishDate |
2013 |
url |
http://hdl.handle.net/11391/1216690 https://doi.org/10.1073/pnas.1306290110 |
geographic |
Canada Greenland Indian Pacific |
geographic_facet |
Canada Greenland Indian Pacific |
genre |
aleut eskimo* Eskimo–Aleut Greenland Paleo-Eskimo Alaska Beringia |
genre_facet |
aleut eskimo* Eskimo–Aleut Greenland Paleo-Eskimo Alaska Beringia |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/23940335 info:eu-repo/semantics/altIdentifier/wos/WOS:000323564600051 volume:110 issue:35 firstpage:14308 lastpage:14313 numberofpages:6 journal:PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA http://hdl.handle.net/11391/1216690 doi:10.1073/pnas.1306290110 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84883332476 |
op_doi |
https://doi.org/10.1073/pnas.1306290110 |
container_title |
Proceedings of the National Academy of Sciences |
container_volume |
110 |
container_issue |
35 |
container_start_page |
14308 |
op_container_end_page |
14313 |
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