Fine mapping of a salmonid E2 alphavirus neutralizing epitope

• Published in: Journal of General Virology
• Main Authors: Mérour, Emilie, Lamoureux, Annie, Biacchesi, Stephane, Bremont, Michel
• Other Authors: Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Université Paris Saclay (COmUE), National Research Agency ANR 11 BSV302302
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2016
• Subjects: sleeping-disease-virus; atlantic salmon; transmission pancreas disease; rainbow-trout; antibodies; vertical; glycoprotein; infections; [SDV]Life Sciences [q-bio]; Sav’; Atlantic salmon
• Online Access: https://hal.inrae.fr/hal-02639636; https://doi.org/10.1099/jgv.0.000411

International audience In this study, we aimed to characterize the epitope recognized by the neutralizing 17H23 mAb directed against the E2 glycoprotein of most of salmonid alphavirus (SAV) subtypes and widely used in several laboratories to routinely diagnose SAV. We hypothesized that the 17H23 epi...