Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium
Objectives: This study investigates differences between women and men in heart failure (HF) risk and mortality. Background: Sex differences in HF epidemiology are insufficiently understood. Methods: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from comm...
Published in: | JACC: Heart Failure |
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Online Access: | http://hdl.handle.net/11383/2077478 https://doi.org/10.1016/j.jchf.2018.08.008 http://www.journals.elsevier.com/jacc-heart-failure |
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ftuninsubriairis:oai:irinsubria.uninsubria.it:11383/2077478 2024-04-14T08:16:43+00:00 Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M. Gianfagna, Francesco Blankenberg, Stefan Vartiainen, Erkki Sans, Susana Pasterkamp, Gerard Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M. Gianfagna, Francesco Blankenberg, Stefan Vartiainen, Erkki Sans, Susana Pasterkamp, Gerard Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. 2019 http://hdl.handle.net/11383/2077478 https://doi.org/10.1016/j.jchf.2018.08.008 http://www.journals.elsevier.com/jacc-heart-failure eng eng Elsevier Inc. info:eu-repo/semantics/altIdentifier/pmid/30819375 info:eu-repo/semantics/altIdentifier/wos/WOS:000460037600003 volume:7 issue:3 firstpage:204 lastpage:213 numberofpages:10 journal:JACC. HEART FAILURE http://hdl.handle.net/11383/2077478 doi:10.1016/j.jchf.2018.08.008 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85061563131 http://www.journals.elsevier.com/jacc-heart-failure biomarker cohort epidemiology heart failure mortality sex Cardiology and Cardiovascular Medicine info:eu-repo/semantics/article 2019 ftuninsubriairis https://doi.org/10.1016/j.jchf.2018.08.008 2024-03-21T19:05:14Z Objectives: This study investigates differences between women and men in heart failure (HF) risk and mortality. Background: Sex differences in HF epidemiology are insufficiently understood. Methods: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro–B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men. Results: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men. Conclusions: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women. Article in Journal/Newspaper Northern Sweden IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) Moli ENVELOPE(19.182,19.182,69.227,69.227) JACC: Heart Failure 7 3 204 213 |
institution |
Open Polar |
collection |
IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
op_collection_id |
ftuninsubriairis |
language |
English |
topic |
biomarker cohort epidemiology heart failure mortality sex Cardiology and Cardiovascular Medicine |
spellingShingle |
biomarker cohort epidemiology heart failure mortality sex Cardiology and Cardiovascular Medicine Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M. Gianfagna, Francesco Blankenberg, Stefan Vartiainen, Erkki Sans, Susana Pasterkamp, Gerard Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium |
topic_facet |
biomarker cohort epidemiology heart failure mortality sex Cardiology and Cardiovascular Medicine |
description |
Objectives: This study investigates differences between women and men in heart failure (HF) risk and mortality. Background: Sex differences in HF epidemiology are insufficiently understood. Methods: In 78,657 individuals (median 49.5 years of age; age range 24.1 to 98.7 years; 51.7% women) from community-based European studies (FINRISK, DanMONICA, Moli-sani, Northern Sweden) of the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium, the association between incident HF and mortality, the relationship of cardiovascular risk factors, prevalent cardiovascular diseases, biomarkers (C-reactive protein [CRP]; N-terminal pro–B-type natriuretic peptide [NT-proBNP]) with incident HF, and their attributable risks were tested in women vs. men. Results: Over a median follow-up of 12.7 years, fewer HF cases were observed in women (n = 2,399 [5.9%]) than in men (n = 2,771 [7.3%]). HF incidence increased markedly after 60 years of age, initially with a more rapid increase in men, whereas incidence in women exceeded that of men after 85 years of age. HF onset substantially increased mortality risk in both sexes. Multivariable-adjusted Cox models showed the following sex differences for the association with incident HF: systolic blood pressure hazard ratio (HR) according to SD in women of 1.09 (95% confidence interval [CI]: 1.05 to 1.14) versus HR of 1.19 (95% CI: 1.14 to 1.24) in men; heart rate HR of 0.98 (95% CI: 0.93 to 1.03) in women versus HR of 1.09 (95% CI: 1.04 to 1.13) in men; CRP HR of 1.10 (95% CI: 1.00 to 1.20) in women versus HR of 1.32 (95% CI: 1.24 to 1.41) in men; and NT-proBNP HR of 1.54 (95% CI: 1.37 to 1.74) in women versus HR of 1.89 (95% CI: 1.75 to 2.05) in men. Population-attributable risk of all risk factors combined was 59.0% in women and 62.9% in men. Conclusions: Women had a lower risk for HF than men. Sex differences were seen for systolic blood pressure, heart rate, CRP, and NT-proBNP, with a lower HF risk in women. |
author2 |
Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M. Gianfagna, Francesco Blankenberg, Stefan Vartiainen, Erkki Sans, Susana Pasterkamp, Gerard Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. |
format |
Article in Journal/Newspaper |
author |
Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M. Gianfagna, Francesco Blankenberg, Stefan Vartiainen, Erkki Sans, Susana Pasterkamp, Gerard Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. |
author_facet |
Magnussen, Christina Niiranen, Teemu J. Ojeda, Francisco M. Gianfagna, Francesco Blankenberg, Stefan Vartiainen, Erkki Sans, Susana Pasterkamp, Gerard Hughes, Maria Costanzo, Simona Donati, Maria Benedetta Jousilahti, Pekka Linneberg, Allan Palosaari, Tarja de Gaetano, Giovanni Bobak, Martin den Ruijter, Hester M. Jørgensen, Torben Söderberg, Stefan Kuulasmaa, Kari Zeller, Tanja Iacoviello, Licia Salomaa, Veikko Schnabel, Renate B. |
author_sort |
Magnussen, Christina |
title |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium |
title_short |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium |
title_full |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium |
title_fullStr |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium |
title_full_unstemmed |
Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium |
title_sort |
sex-specific epidemiology of heart failure risk and mortality in europe: results from the biomarcare consortium |
publisher |
Elsevier Inc. |
publishDate |
2019 |
url |
http://hdl.handle.net/11383/2077478 https://doi.org/10.1016/j.jchf.2018.08.008 http://www.journals.elsevier.com/jacc-heart-failure |
long_lat |
ENVELOPE(19.182,19.182,69.227,69.227) |
geographic |
Moli |
geographic_facet |
Moli |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/30819375 info:eu-repo/semantics/altIdentifier/wos/WOS:000460037600003 volume:7 issue:3 firstpage:204 lastpage:213 numberofpages:10 journal:JACC. HEART FAILURE http://hdl.handle.net/11383/2077478 doi:10.1016/j.jchf.2018.08.008 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85061563131 http://www.journals.elsevier.com/jacc-heart-failure |
op_doi |
https://doi.org/10.1016/j.jchf.2018.08.008 |
container_title |
JACC: Heart Failure |
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7 |
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204 |
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213 |
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