Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)
BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6...
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Online Access: | http://hdl.handle.net/11383/2064797 https://doi.org/10.1161/CIRCULATIONAHA.117.028981 |
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ftuninsubriairis:oai:irinsubria.uninsubria.it:11383/2064797 2024-04-14T08:16:43+00:00 Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) Magnussen, C Niiranen, T Ojeda, Fm GIANFAGNA, FRANCESCO Blankenberg, S Njølstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, Mb Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, Hm Mathiesen, E Jørgensen, T Söderberg, S Kuulasmaa, K Zeller, T IACOVIELLO, LICIA Salomaa, V Schnabel, Rb Magnussen, C Niiranen, T Ojeda, Fm Gianfagna, Francesco Blankenberg, S Njølstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, Mb Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, Hm Mathiesen, E Jørgensen, T Söderberg, S Kuulasmaa, K Zeller, T Iacoviello, Licia Salomaa, V Schnabel, Rb 2017 STAMPA http://hdl.handle.net/11383/2064797 https://doi.org/10.1161/CIRCULATIONAHA.117.028981 eng eng info:eu-repo/semantics/altIdentifier/pmid/29038167 info:eu-repo/semantics/altIdentifier/wos/WOS:000413496200005 volume:136 issue:17 firstpage:1588 lastpage:1597 numberofpages:10 journal:CIRCULATION http://hdl.handle.net/11383/2064797 doi:10.1161/CIRCULATIONAHA.117.028981 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85031775684 Epidemiology public health cardiovascular risk info:eu-repo/semantics/article 2017 ftuninsubriairis https://doi.org/10.1161/CIRCULATIONAHA.117.028981 2024-03-21T19:02:42Z BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Moli-sani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex. Median follow-up time was 12.6 (to a maximum of 28.2) years. RESULTS: Fewer AF cases were observed in women (N=1796; 4.4%), than in men (N=2465; 6.4%). Cardiovascular risk factor distribution and lipid profile at baseline were less beneficial in men than in women, and cardiovascular disease was more prevalent in men. Cumulative incidence increased markedly after the age of 50 years in men and after 60 years in women. The lifetime risk was similar (>30%) for both sexes. Subjects with incident AF had a 3.5-fold risk of death in comparison with those without AF. Multivariable-adjusted models showed sex differences for the association of body mass index and AF (hazard ratio per standard deviation increase, 1.18; 95% confidence interval [CI], 1.12-1.23 in women versus 1.31; 95% CI 1.25-1.38 in men; interaction P value of 0.001). Total cholesterol was inversely associated with incident AF with a greater risk reduction in women (hazard ratio per SD, 0.86; 95% CI, 0.81-0.90 versus 0.92; 95% CI, 0.88-0.97 in men; interaction P value of 0.023). No sex differences were seen for C-reactive protein and N-terminal pro B-type natriuretic peptide. The population-attributable risk of all risk factors combined was 41.9% in women and 46.0% in men. About 20% of the risk was observed for body mass index. CONCLUSIONS: Lifetime risk of AF was high, and AF was strongly associated with ... Article in Journal/Newspaper Northern Sweden IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) Moli ENVELOPE(19.182,19.182,69.227,69.227) Circulation 1 |
institution |
Open Polar |
collection |
IRInSubria - Institutional Repository Insubria (Università degli Studi dell’Insubria) |
op_collection_id |
ftuninsubriairis |
language |
English |
topic |
Epidemiology public health cardiovascular risk |
spellingShingle |
Epidemiology public health cardiovascular risk Magnussen, C Niiranen, T Ojeda, Fm GIANFAGNA, FRANCESCO Blankenberg, S Njølstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, Mb Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, Hm Mathiesen, E Jørgensen, T Söderberg, S Kuulasmaa, K Zeller, T IACOVIELLO, LICIA Salomaa, V Schnabel, Rb Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
topic_facet |
Epidemiology public health cardiovascular risk |
description |
BACKGROUND: Atrial fibrillation (AF) is a common cardiac disease in aging populations with high comorbidity and mortality. Sex differences in AF epidemiology are insufficiently understood. METHODS: In N=79 793 individuals without AF diagnosis at baseline (median age, 49.6 years; age range, 24.1-97.6 years; 51.7% women) from 4 community-based European studies (FINRISK, DanMONICA, Moli-sani Northern Sweden) of the BiomarCaRE consortium (Biomarker for Cardiovascular Risk Assessment in Europe), we examined AF incidence, its association with mortality, common risk factors, biomarkers, and prevalent cardiovascular disease, and their attributable risk by sex. Median follow-up time was 12.6 (to a maximum of 28.2) years. RESULTS: Fewer AF cases were observed in women (N=1796; 4.4%), than in men (N=2465; 6.4%). Cardiovascular risk factor distribution and lipid profile at baseline were less beneficial in men than in women, and cardiovascular disease was more prevalent in men. Cumulative incidence increased markedly after the age of 50 years in men and after 60 years in women. The lifetime risk was similar (>30%) for both sexes. Subjects with incident AF had a 3.5-fold risk of death in comparison with those without AF. Multivariable-adjusted models showed sex differences for the association of body mass index and AF (hazard ratio per standard deviation increase, 1.18; 95% confidence interval [CI], 1.12-1.23 in women versus 1.31; 95% CI 1.25-1.38 in men; interaction P value of 0.001). Total cholesterol was inversely associated with incident AF with a greater risk reduction in women (hazard ratio per SD, 0.86; 95% CI, 0.81-0.90 versus 0.92; 95% CI, 0.88-0.97 in men; interaction P value of 0.023). No sex differences were seen for C-reactive protein and N-terminal pro B-type natriuretic peptide. The population-attributable risk of all risk factors combined was 41.9% in women and 46.0% in men. About 20% of the risk was observed for body mass index. CONCLUSIONS: Lifetime risk of AF was high, and AF was strongly associated with ... |
author2 |
Magnussen, C Niiranen, T Ojeda, Fm Gianfagna, Francesco Blankenberg, S Njølstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, Mb Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, Hm Mathiesen, E Jørgensen, T Söderberg, S Kuulasmaa, K Zeller, T Iacoviello, Licia Salomaa, V Schnabel, Rb |
format |
Article in Journal/Newspaper |
author |
Magnussen, C Niiranen, T Ojeda, Fm GIANFAGNA, FRANCESCO Blankenberg, S Njølstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, Mb Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, Hm Mathiesen, E Jørgensen, T Söderberg, S Kuulasmaa, K Zeller, T IACOVIELLO, LICIA Salomaa, V Schnabel, Rb |
author_facet |
Magnussen, C Niiranen, T Ojeda, Fm GIANFAGNA, FRANCESCO Blankenberg, S Njølstad, I Vartiainen, E Sans, S Pasterkamp, G Hughes, M Costanzo, S Donati, Mb Jousilahti, P Linneberg, A Palosaari, T de Gaetano, G Bobak, M den Ruijter, Hm Mathiesen, E Jørgensen, T Söderberg, S Kuulasmaa, K Zeller, T IACOVIELLO, LICIA Salomaa, V Schnabel, Rb |
author_sort |
Magnussen, C |
title |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_short |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_full |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_fullStr |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_full_unstemmed |
Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) |
title_sort |
sex differences and similarities in atrial fibrillation epidemiology, risk factors, and mortality in community cohorts: results from the biomarcare consortium (biomarker for cardiovascular risk assessment in europe) |
publishDate |
2017 |
url |
http://hdl.handle.net/11383/2064797 https://doi.org/10.1161/CIRCULATIONAHA.117.028981 |
long_lat |
ENVELOPE(19.182,19.182,69.227,69.227) |
geographic |
Moli |
geographic_facet |
Moli |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/29038167 info:eu-repo/semantics/altIdentifier/wos/WOS:000413496200005 volume:136 issue:17 firstpage:1588 lastpage:1597 numberofpages:10 journal:CIRCULATION http://hdl.handle.net/11383/2064797 doi:10.1161/CIRCULATIONAHA.117.028981 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85031775684 |
op_doi |
https://doi.org/10.1161/CIRCULATIONAHA.117.028981 |
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Circulation |
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