Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit
Compared to other North American indigenous populations, Southwest Alaskan Yupiit exhibit very low rates of type 2 diabetes despite the occurrence of common risk factors. Contemporary Yupiit obtain a substantial portion of their calories from traditional foods, which contain high amounts of omega-3...
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ftuninevadalveg:oai:digitalscholarship.unlv.edu:thesesdissertations-1240 2023-05-15T18:46:01+02:00 Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit Kachinski, Julie Jo 2010-05-01T07:00:00Z application/pdf https://digitalscholarship.unlv.edu/thesesdissertations/224 https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1240&context=thesesdissertations English eng Digital Scholarship@UNLV https://digitalscholarship.unlv.edu/thesesdissertations/224 https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1240&context=thesesdissertations IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/ UNLV Theses, Dissertations, Professional Papers, and Capstones Alaskan diet Animal studies Developmental Fish oils Glucose Gluconeogenesis High saturated fat diets Insulin sensitivity Maternal blood sugar levels Maternal diets Omega-3 polyunsaturated fatty acids (PUFAs) Prenatal maternal nutrition Southwest Alaskan Yupiit Type 2 diabetes Western diet Yup'ik Biochemical Phenomena Metabolism and Nutrition Biological and Physical Anthropology Medical Sciences Nutrition Obstetrics and Gynecology text 2010 ftuninevadalveg 2023-01-16T16:16:49Z Compared to other North American indigenous populations, Southwest Alaskan Yupiit exhibit very low rates of type 2 diabetes despite the occurrence of common risk factors. Contemporary Yupiit obtain a substantial portion of their calories from traditional foods, which contain high amounts of omega-3 polyunsaturated fatty acids. Epidemiological and experimental animal research has linked glucose and insulin homeostasis with a diet high in omega-3s. This study used an experimental animal model to explore potential diabetes protective effects (for adult offspring) of prenatal maternal nutrition modeled on traditional locally-obtained Yupiit diets. The results of this study showed that the adult offspring whose mothers consumed a diet modeled on traditional Yup’ik foods during pregnancy were more insulin sensitive (less prone to diabetes) than adult offspring whose mothers received a Western diet prenatally. These findings provide further insight into our understanding of the role that specific maternal nutrients play in programming adult metabolism and have significant implications for dietary intervention strategies aimed at preventing type 2 diabetes. Text Yup'ik Yupiit University of Nevada, Las Vegas: Digital Scholarship@UNLV |
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collection |
University of Nevada, Las Vegas: Digital Scholarship@UNLV |
op_collection_id |
ftuninevadalveg |
language |
English |
topic |
Alaskan diet Animal studies Developmental Fish oils Glucose Gluconeogenesis High saturated fat diets Insulin sensitivity Maternal blood sugar levels Maternal diets Omega-3 polyunsaturated fatty acids (PUFAs) Prenatal maternal nutrition Southwest Alaskan Yupiit Type 2 diabetes Western diet Yup'ik Biochemical Phenomena Metabolism and Nutrition Biological and Physical Anthropology Medical Sciences Nutrition Obstetrics and Gynecology |
spellingShingle |
Alaskan diet Animal studies Developmental Fish oils Glucose Gluconeogenesis High saturated fat diets Insulin sensitivity Maternal blood sugar levels Maternal diets Omega-3 polyunsaturated fatty acids (PUFAs) Prenatal maternal nutrition Southwest Alaskan Yupiit Type 2 diabetes Western diet Yup'ik Biochemical Phenomena Metabolism and Nutrition Biological and Physical Anthropology Medical Sciences Nutrition Obstetrics and Gynecology Kachinski, Julie Jo Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit |
topic_facet |
Alaskan diet Animal studies Developmental Fish oils Glucose Gluconeogenesis High saturated fat diets Insulin sensitivity Maternal blood sugar levels Maternal diets Omega-3 polyunsaturated fatty acids (PUFAs) Prenatal maternal nutrition Southwest Alaskan Yupiit Type 2 diabetes Western diet Yup'ik Biochemical Phenomena Metabolism and Nutrition Biological and Physical Anthropology Medical Sciences Nutrition Obstetrics and Gynecology |
description |
Compared to other North American indigenous populations, Southwest Alaskan Yupiit exhibit very low rates of type 2 diabetes despite the occurrence of common risk factors. Contemporary Yupiit obtain a substantial portion of their calories from traditional foods, which contain high amounts of omega-3 polyunsaturated fatty acids. Epidemiological and experimental animal research has linked glucose and insulin homeostasis with a diet high in omega-3s. This study used an experimental animal model to explore potential diabetes protective effects (for adult offspring) of prenatal maternal nutrition modeled on traditional locally-obtained Yupiit diets. The results of this study showed that the adult offspring whose mothers consumed a diet modeled on traditional Yup’ik foods during pregnancy were more insulin sensitive (less prone to diabetes) than adult offspring whose mothers received a Western diet prenatally. These findings provide further insight into our understanding of the role that specific maternal nutrients play in programming adult metabolism and have significant implications for dietary intervention strategies aimed at preventing type 2 diabetes. |
format |
Text |
author |
Kachinski, Julie Jo |
author_facet |
Kachinski, Julie Jo |
author_sort |
Kachinski, Julie Jo |
title |
Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit |
title_short |
Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit |
title_full |
Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit |
title_fullStr |
Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit |
title_full_unstemmed |
Use of an animal model to explore prenatal predictors of insulin and glucose metabolism in Southwestern Alaskan Yupiit |
title_sort |
use of an animal model to explore prenatal predictors of insulin and glucose metabolism in southwestern alaskan yupiit |
publisher |
Digital Scholarship@UNLV |
publishDate |
2010 |
url |
https://digitalscholarship.unlv.edu/thesesdissertations/224 https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1240&context=thesesdissertations |
genre |
Yup'ik Yupiit |
genre_facet |
Yup'ik Yupiit |
op_source |
UNLV Theses, Dissertations, Professional Papers, and Capstones |
op_relation |
https://digitalscholarship.unlv.edu/thesesdissertations/224 https://digitalscholarship.unlv.edu/cgi/viewcontent.cgi?article=1240&context=thesesdissertations |
op_rights |
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/ |
_version_ |
1766237261172572160 |