IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB

• Published in: Frontiers in Immunology
• Main Authors: Pégorier, Perrine, Bertignac, Morgane, Chentli, Imène, Nguefack Ngoune, Viviane, Folch, Géraldine, Jabado-Michaloud, Joumana, Hadi-Saljoqi, Saida, Giudicelli, Véronique, Duroux, Patrice, Lefranc, Marie-Paule, Kossida, Sofia
• Other Authors: Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), IMGT R© was funded in part by the BIOMED1 (BIOCT930038), Biotechnology BIOTECH2 (BIO4CT960037), fifth PCRDT Quality of Life and Management of Living Resources (QLG2-2000-01287), and sixth PCRDT Information Science and Technology (ImmunoGrid, FP6 IST-028069) programmes of the European Union (EU). IMGT R© received financial support from the GIS IBiSA, BioCampus Montpellier, the Région Occitanie Grand Plateau Technique pour la Recherche (GPTR).This work was granted access to the HPC@LR and to the High Performance Computing (HPC) resources of the Centre Informatique National de l’Enseignement Supérieur (CINES) and to Très Grand Centre de Calcul (TGCC) of the Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA) under the allocation 036029 (2010–2020) made by GENCI (Grand Equipement National de Calcul Intensif)., ANR-10-LABX-0053,MAbImprove,Optimization of therapeutic monoclonal antibodies development Better antibodies, better developed AND better used(2010)
• Format: Article in Journal/Newspaper
• Language: English
• Published: HAL CCSD 2020
• Subjects: IMGT; Immunoinformatics; Immunogenetics; T cell receptor; TRB locus; MESH: Animals; MESH: Cats; MESH: Macaca mulatta; MESH: Multigene Family; MESH: Phylogeny; MESH: Rabbits; MESH: Receptors; Antigen; T-Cell; alpha-beta; MESH: Sheep; MESH: Swine; MESH: Computational Biology; MESH: Databases; Genetic; MESH: Dogs; MESH: Ferrets; MESH: Genes; T-Cell Receptor beta; MESH: Genetic Loci; MESH: Humans; MESH: Immunogenetics; [SDV.IMM]Life Sciences [q-bio]/Immunology; [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM]; Canis lupus
• Online Access: https://hal.science/hal-04113881; https://hal.science/hal-04113881/document; https://hal.science/hal-04113881/file/fimmu-11-00821.pdf; https://doi.org/10.3389/fimmu.2020.00821

International audience IMGT ® , the international ImMunoGeneTics information system ® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT ® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT ® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. T cell receptors are divided into two groups, αβ and γ δ TR, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRβ locus (TRB) was recently described and annotated by IMGT ® biocurators for several veterinary species, i.e., cat (Felis catus), dog (Canis lupus familiaris), ferret (Mustela putorius furo), pig (Sus scrofa), rabbit (Oryctolagus cuniculus), rhesus monkey (Macaca mulatta), and sheep (Ovis aries). The aim of the present study is to compare the genes of the TRB locus among these different veterinary species based on Homo sapiens. The results reveal that there are similarities but also differences including the number of genes by subgroup which may demonstrate duplications and/or deletions during evolution.