Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas
International audience Inhibitors of NF-κB (IκBs) have been implicated as major components of the Rel/NF-κB signaling pathway, which is an important mediator of immune responses throughout much of the animal kingdom. Here we report the first characterization of a bivalve mollusc cDNA that encodes a...
Published in: | Developmental & Comparative Immunology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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Online Access: | https://hal.inrae.fr/hal-02660632 https://doi.org/10.1016/j.dci.2007.06.001 |
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ftunimontpellier:oai:HAL:hal-02660632v1 2023-05-15T15:57:35+02:00 Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas Montagnani, C. Labreuche, Y. Escoubas, Jean-Michel Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) Medical University of South Carolina Charleston (MUSC) Ecologie microbienne des insectes et interactions hôte-pathogène (EMIP) Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2) 2008 https://hal.inrae.fr/hal-02660632 https://doi.org/10.1016/j.dci.2007.06.001 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.dci.2007.06.001 hal-02660632 https://hal.inrae.fr/hal-02660632 doi:10.1016/j.dci.2007.06.001 PRODINRA: 42139 ISSN: 0145-305X Developmental and Comparative Immunology https://hal.inrae.fr/hal-02660632 Developmental and Comparative Immunology, 2008, 32 (3), pp.182-190. ⟨10.1016/j.dci.2007.06.001⟩ SIGNALING PATHWAY Nf-κB IκB INNATE IMMUNITY ANKYRIN CRASSOSTREA GIGAS OYSTER MOLLUSC INVERTEBRATE HUITRE CREUSE [SDV.IMM]Life Sciences [q-bio]/Immunology info:eu-repo/semantics/article Journal articles 2008 ftunimontpellier https://doi.org/10.1016/j.dci.2007.06.001 2022-12-13T23:36:07Z International audience Inhibitors of NF-κB (IκBs) have been implicated as major components of the Rel/NF-κB signaling pathway, which is an important mediator of immune responses throughout much of the animal kingdom. Here we report the first characterization of a bivalve mollusc cDNA that encodes a novel IκB member called Cg-IκB showing the conservation of most IκB protein characteristics. Sequences as well as phylogenetic analyses reveal a high level of identity between not only Cg-IκB and other mollusc and insect IκB-like proteins but also similarities to vertebrate IκB-α and -ε isoforms. Expression analyses demonstrated that the transcript is widely expressed in all oyster tissues. This work is consistent with our previous discovery of several members of an NF-κB pathway in Crassostrea gigas and further sustains the hypothesis of a conserved scheme of immune gene regulation through most of the metazoans. Article in Journal/Newspaper Crassostrea gigas Pacific oyster Université de Montpellier: HAL Pacific Developmental & Comparative Immunology 32 3 182 190 |
institution |
Open Polar |
collection |
Université de Montpellier: HAL |
op_collection_id |
ftunimontpellier |
language |
English |
topic |
SIGNALING PATHWAY Nf-κB IκB INNATE IMMUNITY ANKYRIN CRASSOSTREA GIGAS OYSTER MOLLUSC INVERTEBRATE HUITRE CREUSE [SDV.IMM]Life Sciences [q-bio]/Immunology |
spellingShingle |
SIGNALING PATHWAY Nf-κB IκB INNATE IMMUNITY ANKYRIN CRASSOSTREA GIGAS OYSTER MOLLUSC INVERTEBRATE HUITRE CREUSE [SDV.IMM]Life Sciences [q-bio]/Immunology Montagnani, C. Labreuche, Y. Escoubas, Jean-Michel Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas |
topic_facet |
SIGNALING PATHWAY Nf-κB IκB INNATE IMMUNITY ANKYRIN CRASSOSTREA GIGAS OYSTER MOLLUSC INVERTEBRATE HUITRE CREUSE [SDV.IMM]Life Sciences [q-bio]/Immunology |
description |
International audience Inhibitors of NF-κB (IκBs) have been implicated as major components of the Rel/NF-κB signaling pathway, which is an important mediator of immune responses throughout much of the animal kingdom. Here we report the first characterization of a bivalve mollusc cDNA that encodes a novel IκB member called Cg-IκB showing the conservation of most IκB protein characteristics. Sequences as well as phylogenetic analyses reveal a high level of identity between not only Cg-IκB and other mollusc and insect IκB-like proteins but also similarities to vertebrate IκB-α and -ε isoforms. Expression analyses demonstrated that the transcript is widely expressed in all oyster tissues. This work is consistent with our previous discovery of several members of an NF-κB pathway in Crassostrea gigas and further sustains the hypothesis of a conserved scheme of immune gene regulation through most of the metazoans. |
author2 |
Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) Medical University of South Carolina Charleston (MUSC) Ecologie microbienne des insectes et interactions hôte-pathogène (EMIP) Institut National de la Recherche Agronomique (INRA)-Université Montpellier 2 - Sciences et Techniques (UM2) |
format |
Article in Journal/Newspaper |
author |
Montagnani, C. Labreuche, Y. Escoubas, Jean-Michel |
author_facet |
Montagnani, C. Labreuche, Y. Escoubas, Jean-Michel |
author_sort |
Montagnani, C. |
title |
Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas |
title_short |
Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas |
title_full |
Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas |
title_fullStr |
Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas |
title_full_unstemmed |
Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas |
title_sort |
cg-ijb, a new member of the ijb protein family characterized in the pacific oyster crassostrea gigas |
publisher |
HAL CCSD |
publishDate |
2008 |
url |
https://hal.inrae.fr/hal-02660632 https://doi.org/10.1016/j.dci.2007.06.001 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
ISSN: 0145-305X Developmental and Comparative Immunology https://hal.inrae.fr/hal-02660632 Developmental and Comparative Immunology, 2008, 32 (3), pp.182-190. ⟨10.1016/j.dci.2007.06.001⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.dci.2007.06.001 hal-02660632 https://hal.inrae.fr/hal-02660632 doi:10.1016/j.dci.2007.06.001 PRODINRA: 42139 |
op_doi |
https://doi.org/10.1016/j.dci.2007.06.001 |
container_title |
Developmental & Comparative Immunology |
container_volume |
32 |
container_issue |
3 |
container_start_page |
182 |
op_container_end_page |
190 |
_version_ |
1766393252415537152 |