Cg-IjB, a new member of the IjB protein family characterized in the pacific oyster Crassostrea gigas
International audience Inhibitors of NF-κB (IκBs) have been implicated as major components of the Rel/NF-κB signaling pathway, which is an important mediator of immune responses throughout much of the animal kingdom. Here we report the first characterization of a bivalve mollusc cDNA that encodes a...
Published in: | Developmental & Comparative Immunology |
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Main Authors: | , , |
Other Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
HAL CCSD
2008
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Subjects: | |
Online Access: | https://hal.inrae.fr/hal-02660632 https://doi.org/10.1016/j.dci.2007.06.001 |
Summary: | International audience Inhibitors of NF-κB (IκBs) have been implicated as major components of the Rel/NF-κB signaling pathway, which is an important mediator of immune responses throughout much of the animal kingdom. Here we report the first characterization of a bivalve mollusc cDNA that encodes a novel IκB member called Cg-IκB showing the conservation of most IκB protein characteristics. Sequences as well as phylogenetic analyses reveal a high level of identity between not only Cg-IκB and other mollusc and insect IκB-like proteins but also similarities to vertebrate IκB-α and -ε isoforms. Expression analyses demonstrated that the transcript is widely expressed in all oyster tissues. This work is consistent with our previous discovery of several members of an NF-κB pathway in Crassostrea gigas and further sustains the hypothesis of a conserved scheme of immune gene regulation through most of the metazoans. |
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