Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales
International audience Background: The gene for odontogenic ameloblast-associated (ODAM) is a member of the secretory calcium-binding phosphoprotein gene family. ODAM is primarily expressed in dental tissues including the enamel organ and the junctional epithelium, and may also have pleiotropic func...
Published in: | BMC Evolutionary Biology |
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Online Access: | https://hal.science/hal-02322063 https://hal.science/hal-02322063/document https://hal.science/hal-02322063/file/Springer-BMCEvolBiol-2019.pdf https://doi.org/10.1186/s12862-019-1359-6 |
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ftunimontpellier:oai:HAL:hal-02322063v1 2024-05-19T07:38:02+00:00 Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales Springer, Mark, S Emerling, Christopher, A Gatesy, John Randall, Jason Collin, Matthew Hecker, Nikolai Hiller, Michael Delsuc, Frédéric Institut des Sciences de l'Evolution de Montpellier (UMR ISEM) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE) Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS) Institute of Cellular Medicine Newcastle Newcastle University Newcastle 2019-12 https://hal.science/hal-02322063 https://hal.science/hal-02322063/document https://hal.science/hal-02322063/file/Springer-BMCEvolBiol-2019.pdf https://doi.org/10.1186/s12862-019-1359-6 en eng HAL CCSD BioMed Central info:eu-repo/semantics/altIdentifier/doi/10.1186/s12862-019-1359-6 hal-02322063 https://hal.science/hal-02322063 https://hal.science/hal-02322063/document https://hal.science/hal-02322063/file/Springer-BMCEvolBiol-2019.pdf doi:10.1186/s12862-019-1359-6 info:eu-repo/semantics/OpenAccess ISSN: 1471-2148 BMC Evolutionary Biology https://hal.science/hal-02322063 BMC Evolutionary Biology, 2019, 19 (1), ⟨10.1186/s12862-019-1359-6⟩ [SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] info:eu-repo/semantics/article Journal articles 2019 ftunimontpellier https://doi.org/10.1186/s12862-019-1359-6 2024-05-01T00:35:47Z International audience Background: The gene for odontogenic ameloblast-associated (ODAM) is a member of the secretory calcium-binding phosphoprotein gene family. ODAM is primarily expressed in dental tissues including the enamel organ and the junctional epithelium, and may also have pleiotropic functions that are unrelated to teeth. Here, we leverage the power of natural selection to test competing hypotheses that ODAM is tooth-specific versus pleiotropic. Specifically, we compiled and screened complete protein-coding sequences, plus sequences for flanking intronic regions, for ODAM in 165 placental mammals to determine if this gene contains inactivating mutations in lineages that either lack teeth (baleen whales, pangolins, anteaters) or lack enamel on their teeth (aardvarks, sloths, armadillos), as would be expected if the only essential functions of ODAM are related to tooth development and the adhesion of the gingival junctional epithelium to the enamel tooth surface. Article in Journal/Newspaper baleen whales toothed whales Université de Montpellier: HAL BMC Evolutionary Biology 19 1 |
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Open Polar |
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Université de Montpellier: HAL |
op_collection_id |
ftunimontpellier |
language |
English |
topic |
[SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] |
spellingShingle |
[SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] Springer, Mark, S Emerling, Christopher, A Gatesy, John Randall, Jason Collin, Matthew Hecker, Nikolai Hiller, Michael Delsuc, Frédéric Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
topic_facet |
[SDE.BE]Environmental Sciences/Biodiversity and Ecology [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology [SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE] [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN] |
description |
International audience Background: The gene for odontogenic ameloblast-associated (ODAM) is a member of the secretory calcium-binding phosphoprotein gene family. ODAM is primarily expressed in dental tissues including the enamel organ and the junctional epithelium, and may also have pleiotropic functions that are unrelated to teeth. Here, we leverage the power of natural selection to test competing hypotheses that ODAM is tooth-specific versus pleiotropic. Specifically, we compiled and screened complete protein-coding sequences, plus sequences for flanking intronic regions, for ODAM in 165 placental mammals to determine if this gene contains inactivating mutations in lineages that either lack teeth (baleen whales, pangolins, anteaters) or lack enamel on their teeth (aardvarks, sloths, armadillos), as would be expected if the only essential functions of ODAM are related to tooth development and the adhesion of the gingival junctional epithelium to the enamel tooth surface. |
author2 |
Institut des Sciences de l'Evolution de Montpellier (UMR ISEM) Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE) Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement IRD : UR226-Centre National de la Recherche Scientifique (CNRS) Institute of Cellular Medicine Newcastle Newcastle University Newcastle |
format |
Article in Journal/Newspaper |
author |
Springer, Mark, S Emerling, Christopher, A Gatesy, John Randall, Jason Collin, Matthew Hecker, Nikolai Hiller, Michael Delsuc, Frédéric |
author_facet |
Springer, Mark, S Emerling, Christopher, A Gatesy, John Randall, Jason Collin, Matthew Hecker, Nikolai Hiller, Michael Delsuc, Frédéric |
author_sort |
Springer, Mark, S |
title |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_short |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_full |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_fullStr |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_full_unstemmed |
Odontogenic ameloblast-associated (ODAM) is inactivated in toothless/enamelless placental mammals and toothed whales |
title_sort |
odontogenic ameloblast-associated (odam) is inactivated in toothless/enamelless placental mammals and toothed whales |
publisher |
HAL CCSD |
publishDate |
2019 |
url |
https://hal.science/hal-02322063 https://hal.science/hal-02322063/document https://hal.science/hal-02322063/file/Springer-BMCEvolBiol-2019.pdf https://doi.org/10.1186/s12862-019-1359-6 |
genre |
baleen whales toothed whales |
genre_facet |
baleen whales toothed whales |
op_source |
ISSN: 1471-2148 BMC Evolutionary Biology https://hal.science/hal-02322063 BMC Evolutionary Biology, 2019, 19 (1), ⟨10.1186/s12862-019-1359-6⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12862-019-1359-6 hal-02322063 https://hal.science/hal-02322063 https://hal.science/hal-02322063/document https://hal.science/hal-02322063/file/Springer-BMCEvolBiol-2019.pdf doi:10.1186/s12862-019-1359-6 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1186/s12862-019-1359-6 |
container_title |
BMC Evolutionary Biology |
container_volume |
19 |
container_issue |
1 |
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1799477421369458688 |