Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas.
International audience Disease is caused by a complex interaction between the pathogen, environment, and the physiological status of the host. Determining how host ontogeny interacts with water temperature to influence the antiviral response of the Pacific oysters, Crassostrea gigas, is a major goal...
Published in: | Fish & Shellfish Immunology |
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Online Access: | https://hal-sde.archives-ouvertes.fr/hal-01112530 https://doi.org/10.1016/j.fsi.2013.10.026 |
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ftunimontpellier:oai:HAL:hal-01112530v1 2023-05-15T15:58:18+02:00 Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas. Green, T. J. Montagnani, Caroline Benkendorff, Kirsten Robinson,, Nick Speck,, Peter Flinders University of South Australia Ecosystèmes lagunaires : organisation biologique et fonctionnement (ECOLAG) Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS) So Cross Univ, Marine Ecol Res Ctr, Lismore, NSW 2480, Australia 2014-01 https://hal-sde.archives-ouvertes.fr/hal-01112530 https://doi.org/10.1016/j.fsi.2013.10.026 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fsi.2013.10.026 info:eu-repo/semantics/altIdentifier/pmid/24200990 hal-01112530 https://hal-sde.archives-ouvertes.fr/hal-01112530 doi:10.1016/j.fsi.2013.10.026 PUBMED: 24200990 ISSN: 1050-4648 EISSN: 1095-9947 Fish and Shellfish Immunology https://hal-sde.archives-ouvertes.fr/hal-01112530 Fish and Shellfish Immunology, 2014, 36 (1), pp.151-157. ⟨10.1016/j.fsi.2013.10.026⟩ Antiviral response Crassostrea Herpesvirus OsHV-1 Water temperature [SDE.BE]Environmental Sciences/Biodiversity and Ecology info:eu-repo/semantics/article Journal articles 2014 ftunimontpellier https://doi.org/10.1016/j.fsi.2013.10.026 2023-03-31T01:31:25Z International audience Disease is caused by a complex interaction between the pathogen, environment, and the physiological status of the host. Determining how host ontogeny interacts with water temperature to influence the antiviral response of the Pacific oysters, Crassostrea gigas, is a major goal in understanding why juvenile Pacific oysters are dying during summer as a result of the global emergence of a new genotype of the Ostreid herpesvirus, termed OsHV-1 μvar. We measured the effect of temperature (12 vs 22 °C) on the antiviral response of adult and juvenile C. gigas injected with poly I:C. Poly I:C up-regulated the expression of numerous immune genes, including TLR, MyD88, IκB-1, Rel, IRF, MDA5, STING, SOC, PKR, Viperin and Mpeg1. At 22 °C, these immune genes showed significant up-regulation in juvenile and adult oysters, but the majority of these genes were up-regulated 12 h post-injection for juveniles compared to 26 h for adults. At 12 °C, the response of these genes was completely inhibited in juveniles and delayed in adults. Temperature and age had no effect on hemolymph antiviral activity against herpes simplex virus (HSV-1). These results suggest that oysters rely on a cellular response to minimise viral replication, involving recognition of virus-associated molecular patterns to induce host cells into an antiviral state, as opposed to producing broad-spectrum antiviral compounds. This cellular response, measured by antiviral gene expression of circulating hemocytes, was influenced by temperature and oyster age. We speculate whether the vigorous antiviral response of juveniles at 22 °C results in an immune-mediated disorder causing mortality Article in Journal/Newspaper Crassostrea gigas Pacific oyster Université de Montpellier: HAL Pacific Fish & Shellfish Immunology 36 1 151 157 |
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Open Polar |
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Université de Montpellier: HAL |
op_collection_id |
ftunimontpellier |
language |
English |
topic |
Antiviral response Crassostrea Herpesvirus OsHV-1 Water temperature [SDE.BE]Environmental Sciences/Biodiversity and Ecology |
spellingShingle |
Antiviral response Crassostrea Herpesvirus OsHV-1 Water temperature [SDE.BE]Environmental Sciences/Biodiversity and Ecology Green, T. J. Montagnani, Caroline Benkendorff, Kirsten Robinson,, Nick Speck,, Peter Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas. |
topic_facet |
Antiviral response Crassostrea Herpesvirus OsHV-1 Water temperature [SDE.BE]Environmental Sciences/Biodiversity and Ecology |
description |
International audience Disease is caused by a complex interaction between the pathogen, environment, and the physiological status of the host. Determining how host ontogeny interacts with water temperature to influence the antiviral response of the Pacific oysters, Crassostrea gigas, is a major goal in understanding why juvenile Pacific oysters are dying during summer as a result of the global emergence of a new genotype of the Ostreid herpesvirus, termed OsHV-1 μvar. We measured the effect of temperature (12 vs 22 °C) on the antiviral response of adult and juvenile C. gigas injected with poly I:C. Poly I:C up-regulated the expression of numerous immune genes, including TLR, MyD88, IκB-1, Rel, IRF, MDA5, STING, SOC, PKR, Viperin and Mpeg1. At 22 °C, these immune genes showed significant up-regulation in juvenile and adult oysters, but the majority of these genes were up-regulated 12 h post-injection for juveniles compared to 26 h for adults. At 12 °C, the response of these genes was completely inhibited in juveniles and delayed in adults. Temperature and age had no effect on hemolymph antiviral activity against herpes simplex virus (HSV-1). These results suggest that oysters rely on a cellular response to minimise viral replication, involving recognition of virus-associated molecular patterns to induce host cells into an antiviral state, as opposed to producing broad-spectrum antiviral compounds. This cellular response, measured by antiviral gene expression of circulating hemocytes, was influenced by temperature and oyster age. We speculate whether the vigorous antiviral response of juveniles at 22 °C results in an immune-mediated disorder causing mortality |
author2 |
Flinders University of South Australia Ecosystèmes lagunaires : organisation biologique et fonctionnement (ECOLAG) Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS) So Cross Univ, Marine Ecol Res Ctr, Lismore, NSW 2480, Australia |
format |
Article in Journal/Newspaper |
author |
Green, T. J. Montagnani, Caroline Benkendorff, Kirsten Robinson,, Nick Speck,, Peter |
author_facet |
Green, T. J. Montagnani, Caroline Benkendorff, Kirsten Robinson,, Nick Speck,, Peter |
author_sort |
Green, T. J. |
title |
Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas. |
title_short |
Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas. |
title_full |
Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas. |
title_fullStr |
Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas. |
title_full_unstemmed |
Ontogeny and water temperature influences the antiviral response of the Pacific oyster, Crassostrea gigas. |
title_sort |
ontogeny and water temperature influences the antiviral response of the pacific oyster, crassostrea gigas. |
publisher |
HAL CCSD |
publishDate |
2014 |
url |
https://hal-sde.archives-ouvertes.fr/hal-01112530 https://doi.org/10.1016/j.fsi.2013.10.026 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
ISSN: 1050-4648 EISSN: 1095-9947 Fish and Shellfish Immunology https://hal-sde.archives-ouvertes.fr/hal-01112530 Fish and Shellfish Immunology, 2014, 36 (1), pp.151-157. ⟨10.1016/j.fsi.2013.10.026⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fsi.2013.10.026 info:eu-repo/semantics/altIdentifier/pmid/24200990 hal-01112530 https://hal-sde.archives-ouvertes.fr/hal-01112530 doi:10.1016/j.fsi.2013.10.026 PUBMED: 24200990 |
op_doi |
https://doi.org/10.1016/j.fsi.2013.10.026 |
container_title |
Fish & Shellfish Immunology |
container_volume |
36 |
container_issue |
1 |
container_start_page |
151 |
op_container_end_page |
157 |
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1766394039632920576 |