Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores
An ongoing canine distemper epidemic was first detected in Switzerland in the spring of 2009. Compared to previous local canine distemper outbreaks, it was characterized by unusually high morbidity and mortality, rapid spread over the country, and susceptibility of several wild carnivore species. He...
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Online Access: | https://hdl.handle.net/11570/3258660 https://doi.org/10.1177/0300985812436743 |
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ftunimessinairis:oai:iris.unime.it:11570/3258660 2024-04-21T08:13:07+00:00 Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores Origgi, F Plattet, P Sattler, U Robert, N Casaubon, J Mavrot, F Pewsner, M Wu, N Giovannini, S Oevermann, A Stoffel, M H Gaschen, V Segner, H Ryser-Degiorgis, M-P Origgi, F Plattet, P Sattler, U Robert, N Casaubon, J Mavrot, F Pewsner, M Wu, N Giovannini, S Oevermann, A Stoffel, M H Gaschen, V Segner, H Ryser-Degiorgis, M-P 2012 https://hdl.handle.net/11570/3258660 https://doi.org/10.1177/0300985812436743 eng eng SAGE PUBLICATIONS INC info:eu-repo/semantics/altIdentifier/pmid/22362965 info:eu-repo/semantics/altIdentifier/wos/WOS:000310853200006 volume:49 issue:6 firstpage:913 lastpage:929 numberofpages:17 journal:VETERINARY PATHOLOGY https://hdl.handle.net/11570/3258660 doi:10.1177/0300985812436743 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84860848067 canine distemper viru lynx fox H301F hemagglutinin meningopolioencephaliti Switzerland wild carnivores info:eu-repo/semantics/article 2012 ftunimessinairis https://doi.org/10.1177/0300985812436743 2024-03-25T18:10:00Z An ongoing canine distemper epidemic was first detected in Switzerland in the spring of 2009. Compared to previous local canine distemper outbreaks, it was characterized by unusually high morbidity and mortality, rapid spread over the country, and susceptibility of several wild carnivore species. Here, the authors describe the associated pathologic changes and phylogenetic and biological features of a multiple highly virulent canine distemper virus (CDV) strain detected in and/or isolated from red foxes (Vulpes vulpes), Eurasian badgers (Meles meles), stone (Martes foina) and pine (Martes martes) martens, from a Eurasian lynx (Lynx lynx), and a domestic dog. The main lesions included interstitial to bronchointerstitial pneumonia and meningopolioencephalitis, whereas demyelination-the classic presentation of CDV infection-was observed in few cases only. In the brain lesions, viral inclusions were mainly in the nuclei of the neurons. Some significant differences in brain and lung lesions were observed between foxes and mustelids. Swiss CDV isolates shared together with a Hungarian CDV strain detected in 2004. In vitro analysis of the hemagglutinin protein from one of the Swiss CDV strains revealed functional and structural differences from that of the reference strain A75/17, with the Swiss strain showing increased surface expression and binding efficiency to the signaling lymphocyte activation molecule (SLAM). These features might be part of a novel molecular signature, which might have contributed to an increase in virus pathogenicity, partially explaining the high morbidity and mortality, the rapid spread, and the large host spectrum observed in this outbreak. Article in Journal/Newspaper Lynx Lynx lynx lynx Università degli Studi di Messina: IRIS Veterinary Pathology 49 6 913 929 |
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Università degli Studi di Messina: IRIS |
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ftunimessinairis |
language |
English |
topic |
canine distemper viru lynx fox H301F hemagglutinin meningopolioencephaliti Switzerland wild carnivores |
spellingShingle |
canine distemper viru lynx fox H301F hemagglutinin meningopolioencephaliti Switzerland wild carnivores Origgi, F Plattet, P Sattler, U Robert, N Casaubon, J Mavrot, F Pewsner, M Wu, N Giovannini, S Oevermann, A Stoffel, M H Gaschen, V Segner, H Ryser-Degiorgis, M-P Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores |
topic_facet |
canine distemper viru lynx fox H301F hemagglutinin meningopolioencephaliti Switzerland wild carnivores |
description |
An ongoing canine distemper epidemic was first detected in Switzerland in the spring of 2009. Compared to previous local canine distemper outbreaks, it was characterized by unusually high morbidity and mortality, rapid spread over the country, and susceptibility of several wild carnivore species. Here, the authors describe the associated pathologic changes and phylogenetic and biological features of a multiple highly virulent canine distemper virus (CDV) strain detected in and/or isolated from red foxes (Vulpes vulpes), Eurasian badgers (Meles meles), stone (Martes foina) and pine (Martes martes) martens, from a Eurasian lynx (Lynx lynx), and a domestic dog. The main lesions included interstitial to bronchointerstitial pneumonia and meningopolioencephalitis, whereas demyelination-the classic presentation of CDV infection-was observed in few cases only. In the brain lesions, viral inclusions were mainly in the nuclei of the neurons. Some significant differences in brain and lung lesions were observed between foxes and mustelids. Swiss CDV isolates shared together with a Hungarian CDV strain detected in 2004. In vitro analysis of the hemagglutinin protein from one of the Swiss CDV strains revealed functional and structural differences from that of the reference strain A75/17, with the Swiss strain showing increased surface expression and binding efficiency to the signaling lymphocyte activation molecule (SLAM). These features might be part of a novel molecular signature, which might have contributed to an increase in virus pathogenicity, partially explaining the high morbidity and mortality, the rapid spread, and the large host spectrum observed in this outbreak. |
author2 |
Origgi, F Plattet, P Sattler, U Robert, N Casaubon, J Mavrot, F Pewsner, M Wu, N Giovannini, S Oevermann, A Stoffel, M H Gaschen, V Segner, H Ryser-Degiorgis, M-P |
format |
Article in Journal/Newspaper |
author |
Origgi, F Plattet, P Sattler, U Robert, N Casaubon, J Mavrot, F Pewsner, M Wu, N Giovannini, S Oevermann, A Stoffel, M H Gaschen, V Segner, H Ryser-Degiorgis, M-P |
author_facet |
Origgi, F Plattet, P Sattler, U Robert, N Casaubon, J Mavrot, F Pewsner, M Wu, N Giovannini, S Oevermann, A Stoffel, M H Gaschen, V Segner, H Ryser-Degiorgis, M-P |
author_sort |
Origgi, F |
title |
Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores |
title_short |
Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores |
title_full |
Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores |
title_fullStr |
Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores |
title_full_unstemmed |
Emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores |
title_sort |
emergence of canine distemper virus strains with modified molecular signature and enhanced neuronal tropism leading to high mortality in wild carnivores |
publisher |
SAGE PUBLICATIONS INC |
publishDate |
2012 |
url |
https://hdl.handle.net/11570/3258660 https://doi.org/10.1177/0300985812436743 |
genre |
Lynx Lynx lynx lynx |
genre_facet |
Lynx Lynx lynx lynx |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/22362965 info:eu-repo/semantics/altIdentifier/wos/WOS:000310853200006 volume:49 issue:6 firstpage:913 lastpage:929 numberofpages:17 journal:VETERINARY PATHOLOGY https://hdl.handle.net/11570/3258660 doi:10.1177/0300985812436743 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84860848067 |
op_doi |
https://doi.org/10.1177/0300985812436743 |
container_title |
Veterinary Pathology |
container_volume |
49 |
container_issue |
6 |
container_start_page |
913 |
op_container_end_page |
929 |
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1796933638471811072 |