The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata)
The gilthead seabream larval rearing in continuous light is common in most Mediterranean hatcheries to stimulate larval length growth and increase food consumption. Several studies have shown that continuous light affects larval development and increases the prevalence of skeletal deformities. Melat...
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Online Access: | http://hdl.handle.net/11570/3183248 https://doi.org/10.3390/ijms21249597 https://pubmed.ncbi.nlm.nih.gov/33339403/ |
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ftunimessinairis:oai:iris.unime.it:11570/3183248 2024-04-21T07:57:25+00:00 The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata) Mhalhel K. Germana A. Abbate F. Guerrera M. C. Levanti M. Laura R. Montalbano G. Mhalhel, K. Germana, A. Abbate, F. Guerrera, M. C. Levanti, M. Laura, R. Montalbano, G. 2020 ELETTRONICO http://hdl.handle.net/11570/3183248 https://doi.org/10.3390/ijms21249597 https://pubmed.ncbi.nlm.nih.gov/33339403/ eng eng MDPI AG info:eu-repo/semantics/altIdentifier/pmid/33339403 info:eu-repo/semantics/altIdentifier/wos/WOS:000602812800001 volume:21 issue:24 firstpage:1 lastpage:18 numberofpages:18 journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES http://hdl.handle.net/11570/3183248 doi:10.3390/ijms21249597 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85098227217 https://pubmed.ncbi.nlm.nih.gov/33339403/ info:eu-repo/semantics/openAccess Bglap Bone deformity Growth Melatonin Mlc2 Opercular complex PTHrP Sparus aurata info:eu-repo/semantics/article 2020 ftunimessinairis https://doi.org/10.3390/ijms21249597 2024-03-25T18:07:14Z The gilthead seabream larval rearing in continuous light is common in most Mediterranean hatcheries to stimulate larval length growth and increase food consumption. Several studies have shown that continuous light affects larval development and increases the prevalence of skeletal deformities. Melatonin is a crucial pineal neurohormone that displays daily secretion patterns, stimulates cell proliferation and embryonic development in Atlantic salmon and zebrafish, and improves osseointegration in mice and humans. However, no studies have examined the effects of orally supplemented melatonin on skeletal deformities in Sparus aurata larvae. We administered exogenous melatonin to gilthead seabream larvae via enriched rotifers and nauplii of Artemia. Exogenous melatonin induced bone deformities and stimulated parathyroid hormone-related protein-coding gene (PTHrP) mRNA expression. In addition to the melatonin-induced PTHrP high expression level, the recorded non coordinated function of skeletal muscle and bone during growth can be the fountainhead of bone deformities. Both myosin light chain 2 (mlc2) and bone gamma-carboxyglutamate protein-coding gene (bglap) expression levels were significantly affected by melatonin administration in an inverse dose–response manner during the exogenous melatonin administration. This is the first study to report the effect of inducing melatonin bone deformities on Sparus aurata larvae reared under ordinary hatchery conditions. Article in Journal/Newspaper Atlantic salmon Università degli Studi di Messina: IRIS International Journal of Molecular Sciences 21 24 9597 |
institution |
Open Polar |
collection |
Università degli Studi di Messina: IRIS |
op_collection_id |
ftunimessinairis |
language |
English |
topic |
Bglap Bone deformity Growth Melatonin Mlc2 Opercular complex PTHrP Sparus aurata |
spellingShingle |
Bglap Bone deformity Growth Melatonin Mlc2 Opercular complex PTHrP Sparus aurata Mhalhel K. Germana A. Abbate F. Guerrera M. C. Levanti M. Laura R. Montalbano G. The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata) |
topic_facet |
Bglap Bone deformity Growth Melatonin Mlc2 Opercular complex PTHrP Sparus aurata |
description |
The gilthead seabream larval rearing in continuous light is common in most Mediterranean hatcheries to stimulate larval length growth and increase food consumption. Several studies have shown that continuous light affects larval development and increases the prevalence of skeletal deformities. Melatonin is a crucial pineal neurohormone that displays daily secretion patterns, stimulates cell proliferation and embryonic development in Atlantic salmon and zebrafish, and improves osseointegration in mice and humans. However, no studies have examined the effects of orally supplemented melatonin on skeletal deformities in Sparus aurata larvae. We administered exogenous melatonin to gilthead seabream larvae via enriched rotifers and nauplii of Artemia. Exogenous melatonin induced bone deformities and stimulated parathyroid hormone-related protein-coding gene (PTHrP) mRNA expression. In addition to the melatonin-induced PTHrP high expression level, the recorded non coordinated function of skeletal muscle and bone during growth can be the fountainhead of bone deformities. Both myosin light chain 2 (mlc2) and bone gamma-carboxyglutamate protein-coding gene (bglap) expression levels were significantly affected by melatonin administration in an inverse dose–response manner during the exogenous melatonin administration. This is the first study to report the effect of inducing melatonin bone deformities on Sparus aurata larvae reared under ordinary hatchery conditions. |
author2 |
Mhalhel, K. Germana, A. Abbate, F. Guerrera, M. C. Levanti, M. Laura, R. Montalbano, G. |
format |
Article in Journal/Newspaper |
author |
Mhalhel K. Germana A. Abbate F. Guerrera M. C. Levanti M. Laura R. Montalbano G. |
author_facet |
Mhalhel K. Germana A. Abbate F. Guerrera M. C. Levanti M. Laura R. Montalbano G. |
author_sort |
Mhalhel K. |
title |
The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata) |
title_short |
The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata) |
title_full |
The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata) |
title_fullStr |
The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata) |
title_full_unstemmed |
The effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (Sparus aurata) |
title_sort |
effect of orally supplemented melatonin on larval performance and skeletal deformities in farmed gilthead seabream (sparus aurata) |
publisher |
MDPI AG |
publishDate |
2020 |
url |
http://hdl.handle.net/11570/3183248 https://doi.org/10.3390/ijms21249597 https://pubmed.ncbi.nlm.nih.gov/33339403/ |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/33339403 info:eu-repo/semantics/altIdentifier/wos/WOS:000602812800001 volume:21 issue:24 firstpage:1 lastpage:18 numberofpages:18 journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES http://hdl.handle.net/11570/3183248 doi:10.3390/ijms21249597 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85098227217 https://pubmed.ncbi.nlm.nih.gov/33339403/ |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.3390/ijms21249597 |
container_title |
International Journal of Molecular Sciences |
container_volume |
21 |
container_issue |
24 |
container_start_page |
9597 |
_version_ |
1796939063936155648 |