Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application
Overall, around 15,000 pharmacologically active compounds have been isolated from marine species, many of which are structurally unique and absent in terrestrial organisms. Extremophiles are organisms that have developed specific adaptations that allow them to survive prohibitive conditions for huma...
Main Author: | |
---|---|
Other Authors: | , , , |
Format: | Doctoral or Postdoctoral Thesis |
Language: | English |
Published: |
2019
|
Subjects: | |
Online Access: | http://hdl.handle.net/11570/3146572 |
id |
ftunimessinairis:oai:iris.unime.it:11570/3146572 |
---|---|
record_format |
openpolar |
spelling |
ftunimessinairis:oai:iris.unime.it:11570/3146572 2024-02-11T09:57:36+01:00 Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application GRAZIANO, MARCO Dott.ssa Angelina Lo Giudice (Unime) Dott.ssa Ana Raquel Diaz Marrero (Universidad de la Laguna) Prof. Emilio De Domenico (Unime) Graziano, Marco SPANO', Nunziacarla LO GULLO, Maria Assunta 2019-11-07 http://hdl.handle.net/11570/3146572 eng eng alleditors:Dott.ssa Angelina Lo Giudice (Unime) Dott.ssa Ana Raquel Diaz Marrero (Universidad de la Laguna) Prof. Emilio De Domenico (Unime) http://hdl.handle.net/11570/3146572 info:eu-repo/semantics/openAccess Extremophile bacteria filter-feeding benthic organism biomolecule antiparasitic activity anticancer activity antibacterial activity Ara-C Settore BIO/07 - Ecologia info:eu-repo/semantics/doctoralThesis 2019 ftunimessinairis 2024-01-17T17:39:42Z Overall, around 15,000 pharmacologically active compounds have been isolated from marine species, many of which are structurally unique and absent in terrestrial organisms. Extremophiles are organisms that have developed specific adaptations that allow them to survive prohibitive conditions for humans. The purpose of this work is to combine these two aspects, investigating the associated microbial community with 2 types of filtering organisms, Arctic bivalve molluscs (Margaritifera margaritifera) (Fig.1) and Antarctic poriferous (Calyx arcuaria, Haliclona virens, Haliclona (Rhizoniera) dancoi, Haliclona rudis), to take advantage of potential developed by extremophiles, analyze the secondary metabolites produced and assess the presence of pharmacological properties. In specific, possible antiproliferative, antiparasitic and antimicrobial activities were been evaluated against, most common cancer cell lines, parasitics and pathogenic bacteria. Doctoral or Postdoctoral Thesis Antarc* Antarctic Arctic Università degli Studi di Messina: IRIS Arctic Antarctic |
institution |
Open Polar |
collection |
Università degli Studi di Messina: IRIS |
op_collection_id |
ftunimessinairis |
language |
English |
topic |
Extremophile bacteria filter-feeding benthic organism biomolecule antiparasitic activity anticancer activity antibacterial activity Ara-C Settore BIO/07 - Ecologia |
spellingShingle |
Extremophile bacteria filter-feeding benthic organism biomolecule antiparasitic activity anticancer activity antibacterial activity Ara-C Settore BIO/07 - Ecologia GRAZIANO, MARCO Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application |
topic_facet |
Extremophile bacteria filter-feeding benthic organism biomolecule antiparasitic activity anticancer activity antibacterial activity Ara-C Settore BIO/07 - Ecologia |
description |
Overall, around 15,000 pharmacologically active compounds have been isolated from marine species, many of which are structurally unique and absent in terrestrial organisms. Extremophiles are organisms that have developed specific adaptations that allow them to survive prohibitive conditions for humans. The purpose of this work is to combine these two aspects, investigating the associated microbial community with 2 types of filtering organisms, Arctic bivalve molluscs (Margaritifera margaritifera) (Fig.1) and Antarctic poriferous (Calyx arcuaria, Haliclona virens, Haliclona (Rhizoniera) dancoi, Haliclona rudis), to take advantage of potential developed by extremophiles, analyze the secondary metabolites produced and assess the presence of pharmacological properties. In specific, possible antiproliferative, antiparasitic and antimicrobial activities were been evaluated against, most common cancer cell lines, parasitics and pathogenic bacteria. |
author2 |
Dott.ssa Angelina Lo Giudice (Unime) Dott.ssa Ana Raquel Diaz Marrero (Universidad de la Laguna) Prof. Emilio De Domenico (Unime) Graziano, Marco SPANO', Nunziacarla LO GULLO, Maria Assunta |
format |
Doctoral or Postdoctoral Thesis |
author |
GRAZIANO, MARCO |
author_facet |
GRAZIANO, MARCO |
author_sort |
GRAZIANO, MARCO |
title |
Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application |
title_short |
Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application |
title_full |
Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application |
title_fullStr |
Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application |
title_full_unstemmed |
Cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application |
title_sort |
cold-adapted associated marine bacteria: a source of new biomolecules with pharmaceutical application |
publishDate |
2019 |
url |
http://hdl.handle.net/11570/3146572 |
geographic |
Arctic Antarctic |
geographic_facet |
Arctic Antarctic |
genre |
Antarc* Antarctic Arctic |
genre_facet |
Antarc* Antarctic Arctic |
op_relation |
alleditors:Dott.ssa Angelina Lo Giudice (Unime) Dott.ssa Ana Raquel Diaz Marrero (Universidad de la Laguna) Prof. Emilio De Domenico (Unime) http://hdl.handle.net/11570/3146572 |
op_rights |
info:eu-repo/semantics/openAccess |
_version_ |
1790593144296833024 |