Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss
ABSTRACT: Intestinal adenocarcinomas are uncommon in fishes. To date, they have been reported in zebrafish Danio rerio, blue gularis Fundulopanchax sjostedti, koi carp Cyprinus carpio koi, Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss. Metastases are even rarer and have been obse...
Published in: | Diseases of Aquatic Organisms |
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Inter-Research
2021
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ftuniljubljanair:oai:repozitorij.uni-lj.si:IzpisGradiva.php-id-132351 2023-05-15T15:31:44+02:00 Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik, Vesna Schmidt-Posthaus, Heike 2021-10-22 text/url https://repozitorij.uni-lj.si/IzpisGradiva.php?id=132351 https://repozitorij.uni-lj.si/Dokument.php?id=149968&dn= https://plus.si.cobiss.net/opac7/bib/70336515?lang=sl eng eng Inter-Research info:eu-repo/semantics/altIdentifier/doi/10.3354/dao03592 https://repozitorij.uni-lj.si/IzpisGradiva.php?id=132351 https://repozitorij.uni-lj.si/Dokument.php?id=149968&dn= https://plus.si.cobiss.net/opac7/bib/70336515?lang=sl http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess CC-BY-NC-ND Diseases of aquatic organisms, no. 144, pp. 237-244, 2021. ISSN: 0177-5103 Intestinal adenocarcinoma rainbow trout metastases info:eu-repo/classification/udc/636.09:616 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2021 ftuniljubljanair https://doi.org/10.3354/dao03592 2021-12-06T10:26:55Z ABSTRACT: Intestinal adenocarcinomas are uncommon in fishes. To date, they have been reported in zebrafish Danio rerio, blue gularis Fundulopanchax sjostedti, koi carp Cyprinus carpio koi, Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss. Metastases are even rarer and have been observed so far at very low prevalence, only in feed-induced adenocarcinoma in Atlantic salmon and rainbow trout. Intestinal adenocarcinoma with liver and heart metastases and mesenteric invasion was found in approximately 33% of 4 yr old rainbow trout from a Slovene hatchery with 2000 breeding trout. During stripping, lumps in the abdominal cavity were palpated in one-third of the breeding fish some of the fish were anorectic and lethargic, and mortality was slightly increased. Affected trout were euthanized and 4 were submitted for necropsy and histopathology. Necropsy revealed firm, whitish, irregularly lobular masses originating from the intestine. Histologically, the intestinal masses showed a prominent proliferation of tall columnar neoplastic epithelial cells arranged in dense irregular islands or solid areas and papillotubular protuberances. Solid areas of neoplastic cells were also observed in the mesentery of all trout and in the liver of one trout, whereas minute groups of neoplastic cells were seen in the vessels of the intestinal mucosa in all trout and in the myocardium and the liver of one trout. Epithelial origin of neoplastic cells was confirmed by expression of the cytokeratin marker AE1/AE3. The intestinal masses were diagnosed as intestinal adenocarcinoma with mesenteric invasion and metastases to the liver and heart. The cause of intestinal adenocarcinoma was not determined. Article in Journal/Newspaper Atlantic salmon Salmo salar Repository of the University of Ljubljana (RUL) Diseases of Aquatic Organisms 144 237 244 |
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Open Polar |
collection |
Repository of the University of Ljubljana (RUL) |
op_collection_id |
ftuniljubljanair |
language |
English |
topic |
Intestinal adenocarcinoma rainbow trout metastases info:eu-repo/classification/udc/636.09:616 |
spellingShingle |
Intestinal adenocarcinoma rainbow trout metastases info:eu-repo/classification/udc/636.09:616 Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik, Vesna Schmidt-Posthaus, Heike Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss |
topic_facet |
Intestinal adenocarcinoma rainbow trout metastases info:eu-repo/classification/udc/636.09:616 |
description |
ABSTRACT: Intestinal adenocarcinomas are uncommon in fishes. To date, they have been reported in zebrafish Danio rerio, blue gularis Fundulopanchax sjostedti, koi carp Cyprinus carpio koi, Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss. Metastases are even rarer and have been observed so far at very low prevalence, only in feed-induced adenocarcinoma in Atlantic salmon and rainbow trout. Intestinal adenocarcinoma with liver and heart metastases and mesenteric invasion was found in approximately 33% of 4 yr old rainbow trout from a Slovene hatchery with 2000 breeding trout. During stripping, lumps in the abdominal cavity were palpated in one-third of the breeding fish some of the fish were anorectic and lethargic, and mortality was slightly increased. Affected trout were euthanized and 4 were submitted for necropsy and histopathology. Necropsy revealed firm, whitish, irregularly lobular masses originating from the intestine. Histologically, the intestinal masses showed a prominent proliferation of tall columnar neoplastic epithelial cells arranged in dense irregular islands or solid areas and papillotubular protuberances. Solid areas of neoplastic cells were also observed in the mesentery of all trout and in the liver of one trout, whereas minute groups of neoplastic cells were seen in the vessels of the intestinal mucosa in all trout and in the myocardium and the liver of one trout. Epithelial origin of neoplastic cells was confirmed by expression of the cytokeratin marker AE1/AE3. The intestinal masses were diagnosed as intestinal adenocarcinoma with mesenteric invasion and metastases to the liver and heart. The cause of intestinal adenocarcinoma was not determined. |
format |
Article in Journal/Newspaper |
author |
Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik, Vesna Schmidt-Posthaus, Heike |
author_facet |
Gombač, Mitja Seničar, Marija Švara, Tanja Šturm, Sabina Dolenšek, Tamara Tekavec, Kristina Cerkvenik, Vesna Schmidt-Posthaus, Heike |
author_sort |
Gombač, Mitja |
title |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss |
title_short |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss |
title_full |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss |
title_fullStr |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss |
title_full_unstemmed |
Sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout Oncorhynchus mykiss |
title_sort |
sudden outbreak of metastatic intestinal adenocarcinoma in rainbow trout oncorhynchus mykiss |
publisher |
Inter-Research |
publishDate |
2021 |
url |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=132351 https://repozitorij.uni-lj.si/Dokument.php?id=149968&dn= https://plus.si.cobiss.net/opac7/bib/70336515?lang=sl |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Diseases of aquatic organisms, no. 144, pp. 237-244, 2021. ISSN: 0177-5103 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.3354/dao03592 https://repozitorij.uni-lj.si/IzpisGradiva.php?id=132351 https://repozitorij.uni-lj.si/Dokument.php?id=149968&dn= https://plus.si.cobiss.net/opac7/bib/70336515?lang=sl |
op_rights |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/embargoedAccess |
op_rightsnorm |
CC-BY-NC-ND |
op_doi |
https://doi.org/10.3354/dao03592 |
container_title |
Diseases of Aquatic Organisms |
container_volume |
144 |
container_start_page |
237 |
op_container_end_page |
244 |
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1766362256515268608 |