Influence of population density on antibiotic resistance
Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption w...
Published in: | Journal of Antimicrobial Chemotherapy |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2003
|
Subjects: | |
Online Access: | https://hdl.handle.net/11370/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 https://research.rug.nl/en/publications/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 https://doi.org/10.1093/jac/dkg072 |
id |
ftunigroningenpu:oai:pure.rug.nl:publications/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 |
---|---|
record_format |
openpolar |
spelling |
ftunigroningenpu:oai:pure.rug.nl:publications/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 2024-06-02T08:10:40+00:00 Influence of population density on antibiotic resistance Bruinsma, N Hutchinson, JM van den Bogaard, AE Giamarellou, H Degener, J Stobberingh, EE 2003-02 https://hdl.handle.net/11370/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 https://research.rug.nl/en/publications/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 https://doi.org/10.1093/jac/dkg072 eng eng https://research.rug.nl/en/publications/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 info:eu-repo/semantics/restrictedAccess Bruinsma , N , Hutchinson , JM , van den Bogaard , AE , Giamarellou , H , Degener , J & Stobberingh , EE 2003 , ' Influence of population density on antibiotic resistance ' , Journal of Antimicrobial Chemotherapy , vol. 51 , no. 2 , pp. 385-390 . https://doi.org/10.1093/jac/dkg072 population density antibiotic resistance antibiotic use E. coli enterococci ESCHERICHIA-COLI ANTIMICROBIAL RESISTANCE FECAL SAMPLES HEALTHY-VOLUNTEERS HIGH PREVALENCE NETHERLANDS VENEZUELA CARRIAGE CHILDREN article 2003 ftunigroningenpu https://doi.org/10.1093/jac/dkg072 2024-05-07T18:17:40Z Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption was expressed in DDD (defined daily dose), as DID (DDD/1000 inhabitants/day) and as DSD (DDD/km(2)). The prevalence of antibiotic-resistant Escherichia coli and enterococci was determined in faecal samples of healthy volunteers. In both Newfoundland (28 DID) and Greece (29 DID) the overall consumption of antibiotics was more than three times higher compared with that of The Netherlands (9 DID). The lowest prevalence of resistant E. coli against the majority of antibiotics tested was found for the samples from Newfoundland and was significant (P <0.05) for cefazolin, oxytetracycline and trimethoprim. A poor correlation between the number of DID and the prevalence of resistance was observed [the Pearson correlation coefficient (Pcc) ranged between -0.93 and 0.87]. However, when population density was taken into consideration and antibiotic consumption was expressed in DSD, a strong correlation was observed (and Pcc ranged between 0.86 and 1.00). This study suggests that population density is an important factor in the development of antibiotic resistance and warrants special attention as a factor in resistance epidemiology. Article in Journal/Newspaper Newfoundland University of Groningen research database Canada Journal of Antimicrobial Chemotherapy 51 2 385 390 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
population density antibiotic resistance antibiotic use E. coli enterococci ESCHERICHIA-COLI ANTIMICROBIAL RESISTANCE FECAL SAMPLES HEALTHY-VOLUNTEERS HIGH PREVALENCE NETHERLANDS VENEZUELA CARRIAGE CHILDREN |
spellingShingle |
population density antibiotic resistance antibiotic use E. coli enterococci ESCHERICHIA-COLI ANTIMICROBIAL RESISTANCE FECAL SAMPLES HEALTHY-VOLUNTEERS HIGH PREVALENCE NETHERLANDS VENEZUELA CARRIAGE CHILDREN Bruinsma, N Hutchinson, JM van den Bogaard, AE Giamarellou, H Degener, J Stobberingh, EE Influence of population density on antibiotic resistance |
topic_facet |
population density antibiotic resistance antibiotic use E. coli enterococci ESCHERICHIA-COLI ANTIMICROBIAL RESISTANCE FECAL SAMPLES HEALTHY-VOLUNTEERS HIGH PREVALENCE NETHERLANDS VENEZUELA CARRIAGE CHILDREN |
description |
Antibiotic consumption and population density as a measure of crowding in the community were related to the prevalence of antibiotic resistance of three cities in three different countries: St Johns in Newfoundland (Canada), Athens in Greece and Groningen in The Netherlands. Antibiotic consumption was expressed in DDD (defined daily dose), as DID (DDD/1000 inhabitants/day) and as DSD (DDD/km(2)). The prevalence of antibiotic-resistant Escherichia coli and enterococci was determined in faecal samples of healthy volunteers. In both Newfoundland (28 DID) and Greece (29 DID) the overall consumption of antibiotics was more than three times higher compared with that of The Netherlands (9 DID). The lowest prevalence of resistant E. coli against the majority of antibiotics tested was found for the samples from Newfoundland and was significant (P <0.05) for cefazolin, oxytetracycline and trimethoprim. A poor correlation between the number of DID and the prevalence of resistance was observed [the Pearson correlation coefficient (Pcc) ranged between -0.93 and 0.87]. However, when population density was taken into consideration and antibiotic consumption was expressed in DSD, a strong correlation was observed (and Pcc ranged between 0.86 and 1.00). This study suggests that population density is an important factor in the development of antibiotic resistance and warrants special attention as a factor in resistance epidemiology. |
format |
Article in Journal/Newspaper |
author |
Bruinsma, N Hutchinson, JM van den Bogaard, AE Giamarellou, H Degener, J Stobberingh, EE |
author_facet |
Bruinsma, N Hutchinson, JM van den Bogaard, AE Giamarellou, H Degener, J Stobberingh, EE |
author_sort |
Bruinsma, N |
title |
Influence of population density on antibiotic resistance |
title_short |
Influence of population density on antibiotic resistance |
title_full |
Influence of population density on antibiotic resistance |
title_fullStr |
Influence of population density on antibiotic resistance |
title_full_unstemmed |
Influence of population density on antibiotic resistance |
title_sort |
influence of population density on antibiotic resistance |
publishDate |
2003 |
url |
https://hdl.handle.net/11370/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 https://research.rug.nl/en/publications/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 https://doi.org/10.1093/jac/dkg072 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Bruinsma , N , Hutchinson , JM , van den Bogaard , AE , Giamarellou , H , Degener , J & Stobberingh , EE 2003 , ' Influence of population density on antibiotic resistance ' , Journal of Antimicrobial Chemotherapy , vol. 51 , no. 2 , pp. 385-390 . https://doi.org/10.1093/jac/dkg072 |
op_relation |
https://research.rug.nl/en/publications/ee8b7649-f319-4b2d-abfc-e2e8b033ebc5 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1093/jac/dkg072 |
container_title |
Journal of Antimicrobial Chemotherapy |
container_volume |
51 |
container_issue |
2 |
container_start_page |
385 |
op_container_end_page |
390 |
_version_ |
1800756564661895168 |