Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic?
Background: We cannot predict when an influenza pandemic will occur or which variant of the virus will cause it. Little information is currently available on the ability of laboratories to detect and subtype influenza viruses including the avian influenza viruses. Objectives: To assess the ability o...
Published in: | Journal of Clinical Virology |
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Online Access: | https://hdl.handle.net/11370/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 https://research.rug.nl/en/publications/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 https://doi.org/10.1016/j.jcv.2008.02.005 |
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ftunigroningenpu:oai:pure.rug.nl:publications/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 2024-06-02T08:03:47+00:00 Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic? MacKay, W. G. van Loon, A. M. Niedrig, M. Meijer, A. Lina, B. Niesters, H. G. M. 2008-06 https://hdl.handle.net/11370/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 https://research.rug.nl/en/publications/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 https://doi.org/10.1016/j.jcv.2008.02.005 eng eng https://research.rug.nl/en/publications/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 info:eu-repo/semantics/restrictedAccess MacKay , W G , van Loon , A M , Niedrig , M , Meijer , A , Lina , B & Niesters , H G M 2008 , ' Molecular detection and typing of influenza viruses : Are we ready for an influenza pandemic? ' , Journal of Clinical Virology , vol. 42 , no. 2 , pp. 194-197 . https://doi.org/10.1016/j.jcv.2008.02.005 influenza virus pandemic avian flu molecular diagnostics AVIAN INFLUENZA article 2008 ftunigroningenpu https://doi.org/10.1016/j.jcv.2008.02.005 2024-05-07T18:33:30Z Background: We cannot predict when an influenza pandemic will occur or which variant of the virus will cause it. Little information is currently available on the ability of laboratories to detect and subtype influenza viruses including the avian influenza viruses. Objectives: To assess the ability of laboratories to detect and subtype influenza viruses. Study design: In 2006 QCMD distributed an External Quality Assessment panel for the molecular detection and haemagglutinin subtyping of influenza viruses to 87 laboratories in 34 countries Worldwide, which were given 6 weeks to return results. These data were analysed to assess laboratory performance. Results: Influenza virus positive panel samples were correctly identified by 35-98% of laboratories. The correct haemagglutinin subtype was reported by 32-87% of laboratories that detected the virus: incorrect subtyping results included the reporting of avian influenza viruses as human strains and vice versa. Twelve laboratories reported false positives with some avian influenza viruses reported. Conclusions: These data suggest that improvements are needed in the molecular detection of influenza viruses and influenza virus A haemagglutinin subtyping. Only rapid and accurate identification of circulating pandemic influenza virus will ensure that the maximum time is available for intervention. (c) 2008 Elsevier B.V. All rights reserved. Article in Journal/Newspaper Avian flu University of Groningen research database Journal of Clinical Virology 42 2 194 197 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
influenza virus pandemic avian flu molecular diagnostics AVIAN INFLUENZA |
spellingShingle |
influenza virus pandemic avian flu molecular diagnostics AVIAN INFLUENZA MacKay, W. G. van Loon, A. M. Niedrig, M. Meijer, A. Lina, B. Niesters, H. G. M. Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic? |
topic_facet |
influenza virus pandemic avian flu molecular diagnostics AVIAN INFLUENZA |
description |
Background: We cannot predict when an influenza pandemic will occur or which variant of the virus will cause it. Little information is currently available on the ability of laboratories to detect and subtype influenza viruses including the avian influenza viruses. Objectives: To assess the ability of laboratories to detect and subtype influenza viruses. Study design: In 2006 QCMD distributed an External Quality Assessment panel for the molecular detection and haemagglutinin subtyping of influenza viruses to 87 laboratories in 34 countries Worldwide, which were given 6 weeks to return results. These data were analysed to assess laboratory performance. Results: Influenza virus positive panel samples were correctly identified by 35-98% of laboratories. The correct haemagglutinin subtype was reported by 32-87% of laboratories that detected the virus: incorrect subtyping results included the reporting of avian influenza viruses as human strains and vice versa. Twelve laboratories reported false positives with some avian influenza viruses reported. Conclusions: These data suggest that improvements are needed in the molecular detection of influenza viruses and influenza virus A haemagglutinin subtyping. Only rapid and accurate identification of circulating pandemic influenza virus will ensure that the maximum time is available for intervention. (c) 2008 Elsevier B.V. All rights reserved. |
format |
Article in Journal/Newspaper |
author |
MacKay, W. G. van Loon, A. M. Niedrig, M. Meijer, A. Lina, B. Niesters, H. G. M. |
author_facet |
MacKay, W. G. van Loon, A. M. Niedrig, M. Meijer, A. Lina, B. Niesters, H. G. M. |
author_sort |
MacKay, W. G. |
title |
Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic? |
title_short |
Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic? |
title_full |
Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic? |
title_fullStr |
Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic? |
title_full_unstemmed |
Molecular detection and typing of influenza viruses:Are we ready for an influenza pandemic? |
title_sort |
molecular detection and typing of influenza viruses:are we ready for an influenza pandemic? |
publishDate |
2008 |
url |
https://hdl.handle.net/11370/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 https://research.rug.nl/en/publications/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 https://doi.org/10.1016/j.jcv.2008.02.005 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
MacKay , W G , van Loon , A M , Niedrig , M , Meijer , A , Lina , B & Niesters , H G M 2008 , ' Molecular detection and typing of influenza viruses : Are we ready for an influenza pandemic? ' , Journal of Clinical Virology , vol. 42 , no. 2 , pp. 194-197 . https://doi.org/10.1016/j.jcv.2008.02.005 |
op_relation |
https://research.rug.nl/en/publications/ed6c1a6e-d1f3-41b9-b841-318aa7a1ce62 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1016/j.jcv.2008.02.005 |
container_title |
Journal of Clinical Virology |
container_volume |
42 |
container_issue |
2 |
container_start_page |
194 |
op_container_end_page |
197 |
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1800748387850518528 |