Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird
Trade-offs between immune function and other physiological and behavioural processes are central in ecoimmunology, but one important problem is how to distinguish a reallocation of resources away from the immune system from a reallocation or redistribution within the immune system. While variation i...
Published in: | Journal of Experimental Biology |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
2013
|
Subjects: | |
Online Access: | https://hdl.handle.net/11370/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 https://research.rug.nl/en/publications/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 https://doi.org/10.1242/jeb.083147 https://pure.rug.nl/ws/files/62714672/Immune_response_to_an_endotoxin_challenge_involves_multiple_immune_parameters.pdf |
id |
ftunigroningenpu:oai:pure.rug.nl:publications/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 |
---|---|
record_format |
openpolar |
spelling |
ftunigroningenpu:oai:pure.rug.nl:publications/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 2024-09-09T18:56:01+00:00 Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird Hegemann, Arne Matson, Kevin D. Versteegh, Maaike A. Villegas, Auxiliadora Tieleman, B. Irene 2013-07 application/pdf https://hdl.handle.net/11370/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 https://research.rug.nl/en/publications/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 https://doi.org/10.1242/jeb.083147 https://pure.rug.nl/ws/files/62714672/Immune_response_to_an_endotoxin_challenge_involves_multiple_immune_parameters.pdf eng eng https://research.rug.nl/en/publications/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 info:eu-repo/semantics/openAccess Hegemann , A , Matson , K D , Versteegh , M A , Villegas , A & Tieleman , B I 2013 , ' Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird ' , Journal of Experimental Biology , vol. 216 , no. 14 , pp. 2573-2580 . https://doi.org/10.1242/jeb.083147 inflammation ecological immunology acute phase response lipopolysaccharide LPS annual cycle birds SPARROWS PASSER-DOMESTICUS PHYSIOLOGICAL TRADE-OFFS ACUTE-PHASE RESPONSE HEAT-SHOCK PROTEINS IN-HOUSE SPARROWS HUMORAL IMMUNITY BINDING GLOBULIN BROILER-CHICKENS SEASONAL-CHANGES article 2013 ftunigroningenpu https://doi.org/10.1242/jeb.083147 2024-06-17T15:59:03Z Trade-offs between immune function and other physiological and behavioural processes are central in ecoimmunology, but one important problem is how to distinguish a reallocation of resources away from the immune system from a reallocation or redistribution within the immune system. While variation in baseline values of individual immune parameters is well established, studies in wild animals on multiple parameters during an immune response are lacking. It also remains to be tested whether and how immune responses correlate with baseline values that vary, for example, over the course of an annual cycle. We studied immunological responses to an endotoxin challenge in skylarks (Alauda arvensis), a partial migrant bird breeding in temperate zones. We compared birds injected with the endotoxin LPS with un-injected controls, characterizing immunological responses with leukocyte profiles, titres of lytic enzymes and natural antibodies, and concentrations of haptoglobin and heat shock proteins. We did this in five annual-cycle stages to test whether the response varied throughout the year. The endotoxin challenge affected six of 10 measured parameters. Lysis titres and proportions of heterophils increased; haptoglobin concentrations and proportions of lymphocytes, basophils and eosinophils decreased. The variable effects on different immune components demonstrate the complexity of an immune response. We found no evidence that the response differed between annual-cycle stages. The response was independent of baseline measures taken directly upon capture in the field, indicating that birds were facing no immunological ceiling when mounting an immune response. Values of five parameters collected under field conditions were significantly related to values taken under standardized laboratory conditions. We conclude that multiple parts of the immune system are modulated during an immunological response and that responses are not re-organized throughout the annual cycle. Article in Journal/Newspaper Alauda arvensis University of Groningen research database Journal of Experimental Biology |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
inflammation ecological immunology acute phase response lipopolysaccharide LPS annual cycle birds SPARROWS PASSER-DOMESTICUS PHYSIOLOGICAL TRADE-OFFS ACUTE-PHASE RESPONSE HEAT-SHOCK PROTEINS IN-HOUSE SPARROWS HUMORAL IMMUNITY BINDING GLOBULIN BROILER-CHICKENS SEASONAL-CHANGES |
spellingShingle |
inflammation ecological immunology acute phase response lipopolysaccharide LPS annual cycle birds SPARROWS PASSER-DOMESTICUS PHYSIOLOGICAL TRADE-OFFS ACUTE-PHASE RESPONSE HEAT-SHOCK PROTEINS IN-HOUSE SPARROWS HUMORAL IMMUNITY BINDING GLOBULIN BROILER-CHICKENS SEASONAL-CHANGES Hegemann, Arne Matson, Kevin D. Versteegh, Maaike A. Villegas, Auxiliadora Tieleman, B. Irene Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird |
topic_facet |
inflammation ecological immunology acute phase response lipopolysaccharide LPS annual cycle birds SPARROWS PASSER-DOMESTICUS PHYSIOLOGICAL TRADE-OFFS ACUTE-PHASE RESPONSE HEAT-SHOCK PROTEINS IN-HOUSE SPARROWS HUMORAL IMMUNITY BINDING GLOBULIN BROILER-CHICKENS SEASONAL-CHANGES |
description |
Trade-offs between immune function and other physiological and behavioural processes are central in ecoimmunology, but one important problem is how to distinguish a reallocation of resources away from the immune system from a reallocation or redistribution within the immune system. While variation in baseline values of individual immune parameters is well established, studies in wild animals on multiple parameters during an immune response are lacking. It also remains to be tested whether and how immune responses correlate with baseline values that vary, for example, over the course of an annual cycle. We studied immunological responses to an endotoxin challenge in skylarks (Alauda arvensis), a partial migrant bird breeding in temperate zones. We compared birds injected with the endotoxin LPS with un-injected controls, characterizing immunological responses with leukocyte profiles, titres of lytic enzymes and natural antibodies, and concentrations of haptoglobin and heat shock proteins. We did this in five annual-cycle stages to test whether the response varied throughout the year. The endotoxin challenge affected six of 10 measured parameters. Lysis titres and proportions of heterophils increased; haptoglobin concentrations and proportions of lymphocytes, basophils and eosinophils decreased. The variable effects on different immune components demonstrate the complexity of an immune response. We found no evidence that the response differed between annual-cycle stages. The response was independent of baseline measures taken directly upon capture in the field, indicating that birds were facing no immunological ceiling when mounting an immune response. Values of five parameters collected under field conditions were significantly related to values taken under standardized laboratory conditions. We conclude that multiple parts of the immune system are modulated during an immunological response and that responses are not re-organized throughout the annual cycle. |
format |
Article in Journal/Newspaper |
author |
Hegemann, Arne Matson, Kevin D. Versteegh, Maaike A. Villegas, Auxiliadora Tieleman, B. Irene |
author_facet |
Hegemann, Arne Matson, Kevin D. Versteegh, Maaike A. Villegas, Auxiliadora Tieleman, B. Irene |
author_sort |
Hegemann, Arne |
title |
Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird |
title_short |
Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird |
title_full |
Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird |
title_fullStr |
Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird |
title_full_unstemmed |
Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird |
title_sort |
immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird |
publishDate |
2013 |
url |
https://hdl.handle.net/11370/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 https://research.rug.nl/en/publications/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 https://doi.org/10.1242/jeb.083147 https://pure.rug.nl/ws/files/62714672/Immune_response_to_an_endotoxin_challenge_involves_multiple_immune_parameters.pdf |
genre |
Alauda arvensis |
genre_facet |
Alauda arvensis |
op_source |
Hegemann , A , Matson , K D , Versteegh , M A , Villegas , A & Tieleman , B I 2013 , ' Immune response to an endotoxin challenge involves multiple immune parameters and is consistent among the annual-cycle stages of a free-living temperate zone bird ' , Journal of Experimental Biology , vol. 216 , no. 14 , pp. 2573-2580 . https://doi.org/10.1242/jeb.083147 |
op_relation |
https://research.rug.nl/en/publications/e6c67e54-068d-43c3-9ce6-4ca15b544ba3 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1242/jeb.083147 |
container_title |
Journal of Experimental Biology |
_version_ |
1809935541027733504 |