Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men

• Published in: Atherosclerosis
• Main Authors: Gigante, Bruna, Leander, Karin, Vikstrom, Max, Baldassarre, Damiano, Veglia, Fabrizio, Strawbridge, Rona J., McLeod, Olga, Gertow, Karl, Sennblad, Bengt, Shah, Sonia, Zabaneh, Delilah, Humphries, Steve E., Kauhanen, Jussi p, Rauramaa, Rainer, Smit, Andries J., Mannarino, Elmo, Giral, Philippe, Tremoli, Elena, Hamsten, Anders, Frostegard, Johan, De Faire, Ulf
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2014
• Subjects: Subclinical atherosclerosis; Risk factors; Cardiovascular events; Cardiovascular disease; Biomarker; Anti-PC; Carotid intima media thickness; Carotid intima media thickness progression; MYOCARDIAL-INFARCTION; EUROPEAN POPULATION; NATURAL ANTIBODIES; PROTECTIVE FACTORS; VASCULAR EVENTS; ATHEROSCLEROSIS; PREDICTOR; IMPROVE; TROMSO; WOMEN; Tromso
• Online Access: https://hdl.handle.net/11370/c7b13430-ef42-45e7-a91e-ac324e4bfd26; https://research.rug.nl/en/publications/c7b13430-ef42-45e7-a91e-ac324e4bfd26; https://doi.org/10.1016/j.atherosclerosis.2014.07.030

Objective: Low levels of IgM anti-phosphorylcholine (anti-PC) increase the risk of cardiovascular events (CVE). Here we investigate the association of low anti-PC with the progression of carotid intima media thickness (C-IMT) and incidence of CVE in a large cohort of individuals at high risk of CVE,...