Mechanisms of temperature modulation in mammalian seasonal timing
Global warming is predicted to have major effects on the annual time windows during which species may successfully reproduce. At the organismal level, climatic shifts engage with the control mechanism for reproductive seasonality. In mammals, laboratory studies on neuroendocrine mechanism emphasize...
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2021
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Online Access: | https://hdl.handle.net/11370/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 https://research.rug.nl/en/publications/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 https://doi.org/10.1096/fj.202100162R https://pure.rug.nl/ws/files/169938586/fj.202100162R.pdf |
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ftunigroningenpu:oai:pure.rug.nl:publications/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 2024-06-23T07:54:38+00:00 Mechanisms of temperature modulation in mammalian seasonal timing van Rosmalen, Laura van Dalum, Jayme Appenroth, Daniel Roodenrijs, Renzo T M de Wit, Lauren Hazlerigg, David G Hut, Roelof A 2021 application/pdf https://hdl.handle.net/11370/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 https://research.rug.nl/en/publications/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 https://doi.org/10.1096/fj.202100162R https://pure.rug.nl/ws/files/169938586/fj.202100162R.pdf eng eng https://research.rug.nl/en/publications/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 info:eu-repo/semantics/openAccess van Rosmalen , L , van Dalum , J , Appenroth , D , Roodenrijs , R T M , de Wit , L , Hazlerigg , D G & Hut , R A 2021 , ' Mechanisms of temperature modulation in mammalian seasonal timing ' , The FASEB Journal , vol. 35 , no. 5 , e21605 . https://doi.org/10.1096/fj.202100162R article 2021 ftunigroningenpu https://doi.org/10.1096/fj.202100162R 2024-06-10T17:04:49Z Global warming is predicted to have major effects on the annual time windows during which species may successfully reproduce. At the organismal level, climatic shifts engage with the control mechanism for reproductive seasonality. In mammals, laboratory studies on neuroendocrine mechanism emphasize photoperiod as a predictive cue, but this is based on a restricted group of species. In contrast, field-oriented comparative analyses demonstrate that proximate bioenergetic effects on the reproductive axis are a major determinant of seasonal reproductive timing. The interaction between proximate energetic and predictive photoperiodic cues is neglected. Here, we focused on photoperiodic modulation of postnatal reproductive development in common voles (Microtus arvalis), a herbivorous species in which a plastic timing of breeding is well documented. We demonstrate that temperature-dependent modulation of photoperiodic responses manifest in the thyrotrophin-sensitive tanycytes of the mediobasal hypothalamus. Here, the photoperiod-dependent expression of type 2 deiodinase expression, associated with the summer phenotype was enhanced by 21°C, whereas the photoperiod-dependent expression of type 3 deiodinase expression, associated with the winter phenotype, was enhanced by 10°C in spring voles. Increased levels of testosterone were found at 21°C, whereas somatic and gonadal growth were oppositely affected by temperature. The magnitude of these temperature effects was similar in voles photoperiodical programmed for accelerated maturation (ie, born early in the breeding season) and in voles photoperiodical programmed for delayed maturation (ie, born late in the breeding season). The melatonin-sensitive pars tuberalis was relatively insensitive to temperature. These data define a mechanistic hierarchy for the integration of predictive temporal cues and proximate thermo-energetic effects in mammalian reproduction. Article in Journal/Newspaper Microtus arvalis University of Groningen research database The FASEB Journal 35 5 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
description |
Global warming is predicted to have major effects on the annual time windows during which species may successfully reproduce. At the organismal level, climatic shifts engage with the control mechanism for reproductive seasonality. In mammals, laboratory studies on neuroendocrine mechanism emphasize photoperiod as a predictive cue, but this is based on a restricted group of species. In contrast, field-oriented comparative analyses demonstrate that proximate bioenergetic effects on the reproductive axis are a major determinant of seasonal reproductive timing. The interaction between proximate energetic and predictive photoperiodic cues is neglected. Here, we focused on photoperiodic modulation of postnatal reproductive development in common voles (Microtus arvalis), a herbivorous species in which a plastic timing of breeding is well documented. We demonstrate that temperature-dependent modulation of photoperiodic responses manifest in the thyrotrophin-sensitive tanycytes of the mediobasal hypothalamus. Here, the photoperiod-dependent expression of type 2 deiodinase expression, associated with the summer phenotype was enhanced by 21°C, whereas the photoperiod-dependent expression of type 3 deiodinase expression, associated with the winter phenotype, was enhanced by 10°C in spring voles. Increased levels of testosterone were found at 21°C, whereas somatic and gonadal growth were oppositely affected by temperature. The magnitude of these temperature effects was similar in voles photoperiodical programmed for accelerated maturation (ie, born early in the breeding season) and in voles photoperiodical programmed for delayed maturation (ie, born late in the breeding season). The melatonin-sensitive pars tuberalis was relatively insensitive to temperature. These data define a mechanistic hierarchy for the integration of predictive temporal cues and proximate thermo-energetic effects in mammalian reproduction. |
format |
Article in Journal/Newspaper |
author |
van Rosmalen, Laura van Dalum, Jayme Appenroth, Daniel Roodenrijs, Renzo T M de Wit, Lauren Hazlerigg, David G Hut, Roelof A |
spellingShingle |
van Rosmalen, Laura van Dalum, Jayme Appenroth, Daniel Roodenrijs, Renzo T M de Wit, Lauren Hazlerigg, David G Hut, Roelof A Mechanisms of temperature modulation in mammalian seasonal timing |
author_facet |
van Rosmalen, Laura van Dalum, Jayme Appenroth, Daniel Roodenrijs, Renzo T M de Wit, Lauren Hazlerigg, David G Hut, Roelof A |
author_sort |
van Rosmalen, Laura |
title |
Mechanisms of temperature modulation in mammalian seasonal timing |
title_short |
Mechanisms of temperature modulation in mammalian seasonal timing |
title_full |
Mechanisms of temperature modulation in mammalian seasonal timing |
title_fullStr |
Mechanisms of temperature modulation in mammalian seasonal timing |
title_full_unstemmed |
Mechanisms of temperature modulation in mammalian seasonal timing |
title_sort |
mechanisms of temperature modulation in mammalian seasonal timing |
publishDate |
2021 |
url |
https://hdl.handle.net/11370/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 https://research.rug.nl/en/publications/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 https://doi.org/10.1096/fj.202100162R https://pure.rug.nl/ws/files/169938586/fj.202100162R.pdf |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
van Rosmalen , L , van Dalum , J , Appenroth , D , Roodenrijs , R T M , de Wit , L , Hazlerigg , D G & Hut , R A 2021 , ' Mechanisms of temperature modulation in mammalian seasonal timing ' , The FASEB Journal , vol. 35 , no. 5 , e21605 . https://doi.org/10.1096/fj.202100162R |
op_relation |
https://research.rug.nl/en/publications/bda5dbf6-b809-4e2b-b654-7195bb9ff7b0 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1096/fj.202100162R |
container_title |
The FASEB Journal |
container_volume |
35 |
container_issue |
5 |
_version_ |
1802646852084957184 |