Fat distribution and glucose intolerance among Greenland Inuit
OBJECTIVEA high amount of subcutaneous fat is suggested to explain the observation of lower obesity-associated metabolic risk among Inuit than among Europeans. We examined the association between measures of obesity (visceral adipose tissue [VAT], subcutaneous adipose tissue [SAT], BMI, waist circum...
Published in: | Diabetes Care |
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Online Access: | https://hdl.handle.net/11370/918499f2-eabb-4feb-b9d4-31937945bb17 https://research.rug.nl/en/publications/918499f2-eabb-4feb-b9d4-31937945bb17 https://doi.org/10.2337/dc12-2703 |
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ftunigroningenpu:oai:pure.rug.nl:publications/918499f2-eabb-4feb-b9d4-31937945bb17 2024-09-09T19:42:53+00:00 Fat distribution and glucose intolerance among Greenland Inuit Jørgensen, Marit Eika Borch-Johnsen, Knut Stolk, Ronald Bjerregaard, Peter 2013-10 https://hdl.handle.net/11370/918499f2-eabb-4feb-b9d4-31937945bb17 https://research.rug.nl/en/publications/918499f2-eabb-4feb-b9d4-31937945bb17 https://doi.org/10.2337/dc12-2703 eng eng https://research.rug.nl/en/publications/918499f2-eabb-4feb-b9d4-31937945bb17 info:eu-repo/semantics/restrictedAccess Jørgensen , M E , Borch-Johnsen , K , Stolk , R & Bjerregaard , P 2013 , ' Fat distribution and glucose intolerance among Greenland Inuit ' , Diabetes Care , vol. 36 , no. 10 , pp. 2988-2994 . https://doi.org/10.2337/dc12-2703 Adipose Tissue Adolescent Adult Aged 80 and over Body Mass Index Female Glucose Intolerance Glucose Tolerance Test Greenland Humans Intra-Abdominal Fat Inuits Male Middle Aged Obesity Subcutaneous Fat Waist Circumference Young Adult article 2013 ftunigroningenpu https://doi.org/10.2337/dc12-2703 2024-06-17T15:59:03Z OBJECTIVEA high amount of subcutaneous fat is suggested to explain the observation of lower obesity-associated metabolic risk among Inuit than among Europeans. We examined the association between measures of obesity (visceral adipose tissue [VAT], subcutaneous adipose tissue [SAT], BMI, waist circumference [WC], and percentage of body fat) and the indices of glucose metabolism (fasting and 2-h glucose levels, insulin resistance per homeostasis model assessment [HOMA-IR], and the insulin sensitivity index [ISI0,120]) among Greenland Inuit.RESEARCH DESIGN AND METHODSA total of 3,108 adult Inuit participated in a population-based study. The examination included a 75-g oral glucose tolerance test and anthropometric measurements. VAT and SAT were measured by ultrasound according to a validated protocol. Information on sociodemographic characteristics and health behaviors was obtained by interview.RESULTSMean SATs were 1.8 and 3.5 cm in men and women, respectively. Mean VATs were 7.0 and 6.3 cm in men and women, respectively. The total prevalence of type 2 diabetes was 9%. Percentage of body fat generally was most strongly associated with all outcomes. Both SAT and VAT were significantly associated with glucose intolerance, fasting and 2-h plasma glucose levels, HOMA-IR, and ISI0,120. VAT was more strongly associated with all outcomes than was SAT. After further adjustment for BMI or WC, VAT was associated with glucose intolerance and insulin resistance, whereas there was a trend toward a negative or no association with SAT.CONCLUSIONSHigh mean values of SAT may to a large extent explain the high WC in Inuit populations, and this is suggested to contribute to the lower observed metabolic risk for a given level of obesity. Article in Journal/Newspaper Greenland inuit inuits University of Groningen research database Greenland Diabetes Care 36 10 2988 2994 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
Adipose Tissue Adolescent Adult Aged 80 and over Body Mass Index Female Glucose Intolerance Glucose Tolerance Test Greenland Humans Intra-Abdominal Fat Inuits Male Middle Aged Obesity Subcutaneous Fat Waist Circumference Young Adult |
spellingShingle |
Adipose Tissue Adolescent Adult Aged 80 and over Body Mass Index Female Glucose Intolerance Glucose Tolerance Test Greenland Humans Intra-Abdominal Fat Inuits Male Middle Aged Obesity Subcutaneous Fat Waist Circumference Young Adult Jørgensen, Marit Eika Borch-Johnsen, Knut Stolk, Ronald Bjerregaard, Peter Fat distribution and glucose intolerance among Greenland Inuit |
topic_facet |
Adipose Tissue Adolescent Adult Aged 80 and over Body Mass Index Female Glucose Intolerance Glucose Tolerance Test Greenland Humans Intra-Abdominal Fat Inuits Male Middle Aged Obesity Subcutaneous Fat Waist Circumference Young Adult |
description |
OBJECTIVEA high amount of subcutaneous fat is suggested to explain the observation of lower obesity-associated metabolic risk among Inuit than among Europeans. We examined the association between measures of obesity (visceral adipose tissue [VAT], subcutaneous adipose tissue [SAT], BMI, waist circumference [WC], and percentage of body fat) and the indices of glucose metabolism (fasting and 2-h glucose levels, insulin resistance per homeostasis model assessment [HOMA-IR], and the insulin sensitivity index [ISI0,120]) among Greenland Inuit.RESEARCH DESIGN AND METHODSA total of 3,108 adult Inuit participated in a population-based study. The examination included a 75-g oral glucose tolerance test and anthropometric measurements. VAT and SAT were measured by ultrasound according to a validated protocol. Information on sociodemographic characteristics and health behaviors was obtained by interview.RESULTSMean SATs were 1.8 and 3.5 cm in men and women, respectively. Mean VATs were 7.0 and 6.3 cm in men and women, respectively. The total prevalence of type 2 diabetes was 9%. Percentage of body fat generally was most strongly associated with all outcomes. Both SAT and VAT were significantly associated with glucose intolerance, fasting and 2-h plasma glucose levels, HOMA-IR, and ISI0,120. VAT was more strongly associated with all outcomes than was SAT. After further adjustment for BMI or WC, VAT was associated with glucose intolerance and insulin resistance, whereas there was a trend toward a negative or no association with SAT.CONCLUSIONSHigh mean values of SAT may to a large extent explain the high WC in Inuit populations, and this is suggested to contribute to the lower observed metabolic risk for a given level of obesity. |
format |
Article in Journal/Newspaper |
author |
Jørgensen, Marit Eika Borch-Johnsen, Knut Stolk, Ronald Bjerregaard, Peter |
author_facet |
Jørgensen, Marit Eika Borch-Johnsen, Knut Stolk, Ronald Bjerregaard, Peter |
author_sort |
Jørgensen, Marit Eika |
title |
Fat distribution and glucose intolerance among Greenland Inuit |
title_short |
Fat distribution and glucose intolerance among Greenland Inuit |
title_full |
Fat distribution and glucose intolerance among Greenland Inuit |
title_fullStr |
Fat distribution and glucose intolerance among Greenland Inuit |
title_full_unstemmed |
Fat distribution and glucose intolerance among Greenland Inuit |
title_sort |
fat distribution and glucose intolerance among greenland inuit |
publishDate |
2013 |
url |
https://hdl.handle.net/11370/918499f2-eabb-4feb-b9d4-31937945bb17 https://research.rug.nl/en/publications/918499f2-eabb-4feb-b9d4-31937945bb17 https://doi.org/10.2337/dc12-2703 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuit inuits |
genre_facet |
Greenland inuit inuits |
op_source |
Jørgensen , M E , Borch-Johnsen , K , Stolk , R & Bjerregaard , P 2013 , ' Fat distribution and glucose intolerance among Greenland Inuit ' , Diabetes Care , vol. 36 , no. 10 , pp. 2988-2994 . https://doi.org/10.2337/dc12-2703 |
op_relation |
https://research.rug.nl/en/publications/918499f2-eabb-4feb-b9d4-31937945bb17 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.2337/dc12-2703 |
container_title |
Diabetes Care |
container_volume |
36 |
container_issue |
10 |
container_start_page |
2988 |
op_container_end_page |
2994 |
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1809912187951513600 |