Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica
Plasma corticosterone increases in association with migratory flight in the red knot Calidris canutus islandica, suggesting that corticosterone may promote migratory activity and/or energy mobilization in this species. This hypothesis is supported by general effects of glucocorticoids, which include...
Published in: | Physiological and Biochemical Zoology |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2004
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Online Access: | https://hdl.handle.net/11370/5fdea70a-3be8-451a-9782-18a519f31ab8 https://research.rug.nl/en/publications/5fdea70a-3be8-451a-9782-18a519f31ab8 https://doi.org/10.1086/420942 https://pure.rug.nl/ws/files/6681315/2004PhysiolBiochemZoolLandys.pdf |
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ftunigroningenpu:oai:pure.rug.nl:publications/5fdea70a-3be8-451a-9782-18a519f31ab8 2024-06-02T08:04:47+00:00 Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica Landys, M M Piersma, T Ramenofsky, M Wingfield, John C. 2004 application/pdf https://hdl.handle.net/11370/5fdea70a-3be8-451a-9782-18a519f31ab8 https://research.rug.nl/en/publications/5fdea70a-3be8-451a-9782-18a519f31ab8 https://doi.org/10.1086/420942 https://pure.rug.nl/ws/files/6681315/2004PhysiolBiochemZoolLandys.pdf eng eng https://research.rug.nl/en/publications/5fdea70a-3be8-451a-9782-18a519f31ab8 info:eu-repo/semantics/openAccess Landys , M M , Piersma , T , Ramenofsky , M & Wingfield , J C 2004 , ' Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica ' , Physiological and Biochemical Zoology , vol. 77 , no. 4 , pp. 658-668 . https://doi.org/10.1086/420942 ZONOTRICHIA-LEUCOPHRYS-GAMBELII WHITE-CROWNED SPARROWS CORTICOSTERONE LEVELS PASSERINE BIRDS BASE-LINE URIC-ACID SEASONAL-CHANGES STRESS-RESPONSE SECRETION MECHANISM article 2004 ftunigroningenpu https://doi.org/10.1086/420942 2024-05-07T18:22:03Z Plasma corticosterone increases in association with migratory flight in the red knot Calidris canutus islandica, suggesting that corticosterone may promote migratory activity and/or energy mobilization in this species. This hypothesis is supported by general effects of glucocorticoids, which include stimulation of locomotion and the mobilization of energy depots. We experimentally examined the role of elevated corticosterone levels in the migratory red knot by comparing foraging behavior, flight frequency, and plasma metabolites between vehicle-injected controls and birds treated with RU486, an antagonist to the genomic low-affinity glucocorticoid receptor (GR). We predicted that RU486 treatment would interfere with energy mobilization. However, we expected no effects on flight activity because recent studies suggest that glucocorticoids affect locomotion through a nongenomic receptor. Finally, because glucocorticoids exert permissive effects on food intake, we postulated that RU486 treatment in the red knot would interfere with feeding. Results were consistent with the latter prediction, suggesting that the GR participates in the promotion of hyperphagia, the intense feeding state that is characteristic of the migratory condition. RU486 treatment did not affect flight frequency, suggesting that corticosterone may support migratory activity through a receptor other than the GR. Energy metabolism (as determined through plasma metabolites) was also unaffected by RU486, possibly because energetic demands experienced by captive birds were low. Article in Journal/Newspaper Calidris canutus Red Knot University of Groningen research database Physiological and Biochemical Zoology 77 4 658 668 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
ZONOTRICHIA-LEUCOPHRYS-GAMBELII WHITE-CROWNED SPARROWS CORTICOSTERONE LEVELS PASSERINE BIRDS BASE-LINE URIC-ACID SEASONAL-CHANGES STRESS-RESPONSE SECRETION MECHANISM |
spellingShingle |
ZONOTRICHIA-LEUCOPHRYS-GAMBELII WHITE-CROWNED SPARROWS CORTICOSTERONE LEVELS PASSERINE BIRDS BASE-LINE URIC-ACID SEASONAL-CHANGES STRESS-RESPONSE SECRETION MECHANISM Landys, M M Piersma, T Ramenofsky, M Wingfield, John C. Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica |
topic_facet |
ZONOTRICHIA-LEUCOPHRYS-GAMBELII WHITE-CROWNED SPARROWS CORTICOSTERONE LEVELS PASSERINE BIRDS BASE-LINE URIC-ACID SEASONAL-CHANGES STRESS-RESPONSE SECRETION MECHANISM |
description |
Plasma corticosterone increases in association with migratory flight in the red knot Calidris canutus islandica, suggesting that corticosterone may promote migratory activity and/or energy mobilization in this species. This hypothesis is supported by general effects of glucocorticoids, which include stimulation of locomotion and the mobilization of energy depots. We experimentally examined the role of elevated corticosterone levels in the migratory red knot by comparing foraging behavior, flight frequency, and plasma metabolites between vehicle-injected controls and birds treated with RU486, an antagonist to the genomic low-affinity glucocorticoid receptor (GR). We predicted that RU486 treatment would interfere with energy mobilization. However, we expected no effects on flight activity because recent studies suggest that glucocorticoids affect locomotion through a nongenomic receptor. Finally, because glucocorticoids exert permissive effects on food intake, we postulated that RU486 treatment in the red knot would interfere with feeding. Results were consistent with the latter prediction, suggesting that the GR participates in the promotion of hyperphagia, the intense feeding state that is characteristic of the migratory condition. RU486 treatment did not affect flight frequency, suggesting that corticosterone may support migratory activity through a receptor other than the GR. Energy metabolism (as determined through plasma metabolites) was also unaffected by RU486, possibly because energetic demands experienced by captive birds were low. |
format |
Article in Journal/Newspaper |
author |
Landys, M M Piersma, T Ramenofsky, M Wingfield, John C. |
author_facet |
Landys, M M Piersma, T Ramenofsky, M Wingfield, John C. |
author_sort |
Landys, M M |
title |
Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica |
title_short |
Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica |
title_full |
Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica |
title_fullStr |
Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica |
title_full_unstemmed |
Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica |
title_sort |
role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot calidris canutus islandica |
publishDate |
2004 |
url |
https://hdl.handle.net/11370/5fdea70a-3be8-451a-9782-18a519f31ab8 https://research.rug.nl/en/publications/5fdea70a-3be8-451a-9782-18a519f31ab8 https://doi.org/10.1086/420942 https://pure.rug.nl/ws/files/6681315/2004PhysiolBiochemZoolLandys.pdf |
genre |
Calidris canutus Red Knot |
genre_facet |
Calidris canutus Red Knot |
op_source |
Landys , M M , Piersma , T , Ramenofsky , M & Wingfield , J C 2004 , ' Role of the low-affinity glucocorticoid receptor in the regulation of behavior and energy metabolism in the migratory red knot Calidris canutus islandica ' , Physiological and Biochemical Zoology , vol. 77 , no. 4 , pp. 658-668 . https://doi.org/10.1086/420942 |
op_relation |
https://research.rug.nl/en/publications/5fdea70a-3be8-451a-9782-18a519f31ab8 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1086/420942 |
container_title |
Physiological and Biochemical Zoology |
container_volume |
77 |
container_issue |
4 |
container_start_page |
658 |
op_container_end_page |
668 |
_version_ |
1800749440320929792 |