Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients
Tissue advanced glycation end products (AGEs) are a measure of cumulative metabolic and oxidative stress and cytokine-driven inflammatory reactions. AGEs are thought to contribute to the cardiovascular complications of hemodialysis (HD) patients. Skin autofluorescence (SAF) is related to the tissue...
Published in: | Artificial Organs |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2019
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Online Access: | https://hdl.handle.net/11370/589de6c6-c0e5-4d33-b823-8c69144198c1 https://research.rug.nl/en/publications/589de6c6-c0e5-4d33-b823-8c69144198c1 https://doi.org/10.1111/aor.13320 https://pure.rug.nl/ws/files/92177617/Ramsauer_et_al_2019_Artificial_Organs.pdf |
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ftunigroningenpu:oai:pure.rug.nl:publications/589de6c6-c0e5-4d33-b823-8c69144198c1 2024-06-23T07:55:38+00:00 Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundstrom, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd 2019-02 application/pdf https://hdl.handle.net/11370/589de6c6-c0e5-4d33-b823-8c69144198c1 https://research.rug.nl/en/publications/589de6c6-c0e5-4d33-b823-8c69144198c1 https://doi.org/10.1111/aor.13320 https://pure.rug.nl/ws/files/92177617/Ramsauer_et_al_2019_Artificial_Organs.pdf eng eng https://research.rug.nl/en/publications/589de6c6-c0e5-4d33-b823-8c69144198c1 info:eu-repo/semantics/openAccess Ramsauer , B , Graaff , R , Sikole , A , Trajceska , L , Lundstrom , S , Arsov , S , Hadimeri , H & Stegmayr , B 2019 , ' Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients ' , ARTIFICIAL ORGANS , vol. 43 , no. 2 , pp. 173-180 . https://doi.org/10.1111/aor.13320 Skin autofluorescence Hemodialysis Seasonal variations Advanced glycation end products OXIDATIVE STRESS PREDICTS MORTALITY DIABETES-MELLITUS MAILLARD REACTION ENDPRODUCTS PLASMA ACCUMULATION INCREASE AGES article 2019 ftunigroningenpu https://doi.org/10.1111/aor.13320 2024-06-03T16:50:40Z Tissue advanced glycation end products (AGEs) are a measure of cumulative metabolic and oxidative stress and cytokine-driven inflammatory reactions. AGEs are thought to contribute to the cardiovascular complications of hemodialysis (HD) patients. Skin autofluorescence (SAF) is related to the tissue accumulation of AGEs and rises with age. SAF is one of the strongest prognostic markers of mortality in these patients. The content of AGEs is high in barbecue food. Due to the location in northern Sweden, there is a short intense barbecue season between June and August. The aim of this study was to investigate if seasonal variations in SAF exist in HD patients, especially during the barbecue season. SAF was measured noninvasively with an AGE Reader in 34 HD-patients (15 of those with diabetes mellitus, DM). Each time the median of three measures were used. Skin-AF was measured before and after each one HD at the end of February and May in 31 patients (22 men/9 women); the end of May and August in 28 (20 m/8 w); the end of August and March in 25 (19 m/6 w). Paired statistical analyses were performed during all four periods (n = 23, 17 m/6 w); as was HbA1c of those with DM. There was at a median 5.6% increase in skin-AF during the winter period (February-May, P = 0.004) and a 10.6% decrease in the skin-AF during the summer (May-August, P <0.001). HbA1c in the DM rose during the summer (P = 0.013). In conclusion, skin-AF decreased significantly during the summer. Future studies should look for favorable factors that prevent skin-AF and subsequently cardiovascular diseases. Article in Journal/Newspaper Northern Sweden University of Groningen research database Artificial Organs 43 2 173 180 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
Skin autofluorescence Hemodialysis Seasonal variations Advanced glycation end products OXIDATIVE STRESS PREDICTS MORTALITY DIABETES-MELLITUS MAILLARD REACTION ENDPRODUCTS PLASMA ACCUMULATION INCREASE AGES |
spellingShingle |
Skin autofluorescence Hemodialysis Seasonal variations Advanced glycation end products OXIDATIVE STRESS PREDICTS MORTALITY DIABETES-MELLITUS MAILLARD REACTION ENDPRODUCTS PLASMA ACCUMULATION INCREASE AGES Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundstrom, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
topic_facet |
Skin autofluorescence Hemodialysis Seasonal variations Advanced glycation end products OXIDATIVE STRESS PREDICTS MORTALITY DIABETES-MELLITUS MAILLARD REACTION ENDPRODUCTS PLASMA ACCUMULATION INCREASE AGES |
description |
Tissue advanced glycation end products (AGEs) are a measure of cumulative metabolic and oxidative stress and cytokine-driven inflammatory reactions. AGEs are thought to contribute to the cardiovascular complications of hemodialysis (HD) patients. Skin autofluorescence (SAF) is related to the tissue accumulation of AGEs and rises with age. SAF is one of the strongest prognostic markers of mortality in these patients. The content of AGEs is high in barbecue food. Due to the location in northern Sweden, there is a short intense barbecue season between June and August. The aim of this study was to investigate if seasonal variations in SAF exist in HD patients, especially during the barbecue season. SAF was measured noninvasively with an AGE Reader in 34 HD-patients (15 of those with diabetes mellitus, DM). Each time the median of three measures were used. Skin-AF was measured before and after each one HD at the end of February and May in 31 patients (22 men/9 women); the end of May and August in 28 (20 m/8 w); the end of August and March in 25 (19 m/6 w). Paired statistical analyses were performed during all four periods (n = 23, 17 m/6 w); as was HbA1c of those with DM. There was at a median 5.6% increase in skin-AF during the winter period (February-May, P = 0.004) and a 10.6% decrease in the skin-AF during the summer (May-August, P <0.001). HbA1c in the DM rose during the summer (P = 0.013). In conclusion, skin-AF decreased significantly during the summer. Future studies should look for favorable factors that prevent skin-AF and subsequently cardiovascular diseases. |
format |
Article in Journal/Newspaper |
author |
Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundstrom, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd |
author_facet |
Ramsauer, Bernd Graaff, Reindert Sikole, Aleksandar Trajceska, Lada Lundstrom, Sara Arsov, Stefan Hadimeri, Henrik Stegmayr, Bernd |
author_sort |
Ramsauer, Bernd |
title |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_short |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_full |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_fullStr |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_full_unstemmed |
Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients |
title_sort |
skin autofluorescence, a measure of cumulative metabolic stress and advanced glycation end products, decreases during the summer in dialysis patients |
publishDate |
2019 |
url |
https://hdl.handle.net/11370/589de6c6-c0e5-4d33-b823-8c69144198c1 https://research.rug.nl/en/publications/589de6c6-c0e5-4d33-b823-8c69144198c1 https://doi.org/10.1111/aor.13320 https://pure.rug.nl/ws/files/92177617/Ramsauer_et_al_2019_Artificial_Organs.pdf |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Ramsauer , B , Graaff , R , Sikole , A , Trajceska , L , Lundstrom , S , Arsov , S , Hadimeri , H & Stegmayr , B 2019 , ' Skin Autofluorescence, a Measure of Cumulative Metabolic Stress and Advanced Glycation End Products, Decreases During the Summer in Dialysis Patients ' , ARTIFICIAL ORGANS , vol. 43 , no. 2 , pp. 173-180 . https://doi.org/10.1111/aor.13320 |
op_relation |
https://research.rug.nl/en/publications/589de6c6-c0e5-4d33-b823-8c69144198c1 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1111/aor.13320 |
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Artificial Organs |
container_volume |
43 |
container_issue |
2 |
container_start_page |
173 |
op_container_end_page |
180 |
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