Hydrolase-catalysed preparation of chiral alpha,alpha-disubstituted cyanohydrin acetates

• Published in: Advanced Synthesis & Catalysis
• Main Authors: Holt, Jarle, Arends, Isabel W. C. E., Minnaard, Adriaan J., Hanefeld, Ulf
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2007
• Subjects: asymmetric catalysis; cyanohydrins; enzyme catalysis; hydrolases; kinetic resolution; tertiary alcohols; ENZYMATIC KINETIC RESOLUTION; CHEMOENZYMATIC SYNTHESIS; PROTECTED CYANOHYDRINS; CANDIDA-ANTARCTICA; LIPASE-A; ACID; ENANTIOSELECTIVITY; ESTERS; Rugosa; Antarc*; Antarctica
• Online Access: https://hdl.handle.net/11370/403d6bae-0dd2-4645-b8f1-c8c8713d8d58; https://research.rug.nl/en/publications/403d6bae-0dd2-4645-b8f1-c8c8713d8d58; https://doi.org/10.1002/adsc.200700053

The enzymatic hydrolysis of esters of tertiary alcohols has long been a challenge. In particular their kinetic resolutions have virtually not been addressed. Here we describe the successful kinetic resolution of alpha,alpha-disubstituted cyanohydrin acetates, a type of protected tertiary alcohols th...