Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry
We demonstrate the feasibility of using laser spectrometry (LS) to analyze isotopically highly enriched water samples (i.e., delta H-2 less than or equal to 15000 parts per thousand, delta O-18 less than or equal to 1200 parts per thousand), as often used in the biomedical doubly labeled water (DLW)...
Published in: | Analytical Chemistry |
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Online Access: | https://hdl.handle.net/11370/1e44bd99-3313-461a-8ed2-6e128a2ae375 https://research.rug.nl/en/publications/1e44bd99-3313-461a-8ed2-6e128a2ae375 https://doi.org/10.1021/ac001428j https://pure.rug.nl/ws/files/6663577/2001AnalChemvTrigt.pdf |
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ftunigroningenpu:oai:pure.rug.nl:publications/1e44bd99-3313-461a-8ed2-6e128a2ae375 2024-06-02T08:08:08+00:00 Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry van Trigt, R Kerstel, E.R.T. Visser, GH Meijer, H.A.J. 2001-06-01 application/pdf https://hdl.handle.net/11370/1e44bd99-3313-461a-8ed2-6e128a2ae375 https://research.rug.nl/en/publications/1e44bd99-3313-461a-8ed2-6e128a2ae375 https://doi.org/10.1021/ac001428j https://pure.rug.nl/ws/files/6663577/2001AnalChemvTrigt.pdf eng eng https://research.rug.nl/en/publications/1e44bd99-3313-461a-8ed2-6e128a2ae375 info:eu-repo/semantics/openAccess van Trigt , R , Kerstel , E R T , Visser , GH & Meijer , H A J 2001 , ' Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry ' , Analytical Chemistry , vol. 73 , no. 11 , pp. 2445-2452 . https://doi.org/10.1021/ac001428j LABELED WATER MASS-SPECTROMETRY ICE CORE HYDROGEN REDUCTION DELTA-O-17 ABUNDANCE OXYGEN article 2001 ftunigroningenpu https://doi.org/10.1021/ac001428j 2024-05-07T18:13:59Z We demonstrate the feasibility of using laser spectrometry (LS) to analyze isotopically highly enriched water samples (i.e., delta H-2 less than or equal to 15000 parts per thousand, delta O-18 less than or equal to 1200 parts per thousand), as often used in the biomedical doubly labeled water (DLW) method to quantify energy metabolism. The method is an important extension of a recently developed infrared laser direct absorption spectrometer. The measurements on highly enriched, small-size (10 muL liquid water) samples show a clearly better accuracy for the H-2/H-1 ratio. In the case of O-18/O-16, the same level of accuracy is obtained as with conventional isotope ratio mass spectrometer (IRMS) analysis. With LS, the precision is better for both O-18/O-16 and H-2/H-1. New is the ability to measure O-17/O-16 with the same accuracy as O-18/O-16. A major advantage of the present technique is the absence of chemical sample preparation. The method is proven to be reliable and accurate. and is ready to be used in many biomedical applications. Article in Journal/Newspaper ice core University of Groningen research database Analytical Chemistry 73 11 2445 2452 |
institution |
Open Polar |
collection |
University of Groningen research database |
op_collection_id |
ftunigroningenpu |
language |
English |
topic |
LABELED WATER MASS-SPECTROMETRY ICE CORE HYDROGEN REDUCTION DELTA-O-17 ABUNDANCE OXYGEN |
spellingShingle |
LABELED WATER MASS-SPECTROMETRY ICE CORE HYDROGEN REDUCTION DELTA-O-17 ABUNDANCE OXYGEN van Trigt, R Kerstel, E.R.T. Visser, GH Meijer, H.A.J. Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry |
topic_facet |
LABELED WATER MASS-SPECTROMETRY ICE CORE HYDROGEN REDUCTION DELTA-O-17 ABUNDANCE OXYGEN |
description |
We demonstrate the feasibility of using laser spectrometry (LS) to analyze isotopically highly enriched water samples (i.e., delta H-2 less than or equal to 15000 parts per thousand, delta O-18 less than or equal to 1200 parts per thousand), as often used in the biomedical doubly labeled water (DLW) method to quantify energy metabolism. The method is an important extension of a recently developed infrared laser direct absorption spectrometer. The measurements on highly enriched, small-size (10 muL liquid water) samples show a clearly better accuracy for the H-2/H-1 ratio. In the case of O-18/O-16, the same level of accuracy is obtained as with conventional isotope ratio mass spectrometer (IRMS) analysis. With LS, the precision is better for both O-18/O-16 and H-2/H-1. New is the ability to measure O-17/O-16 with the same accuracy as O-18/O-16. A major advantage of the present technique is the absence of chemical sample preparation. The method is proven to be reliable and accurate. and is ready to be used in many biomedical applications. |
format |
Article in Journal/Newspaper |
author |
van Trigt, R Kerstel, E.R.T. Visser, GH Meijer, H.A.J. |
author_facet |
van Trigt, R Kerstel, E.R.T. Visser, GH Meijer, H.A.J. |
author_sort |
van Trigt, R |
title |
Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry |
title_short |
Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry |
title_full |
Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry |
title_fullStr |
Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry |
title_full_unstemmed |
Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry |
title_sort |
stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry |
publishDate |
2001 |
url |
https://hdl.handle.net/11370/1e44bd99-3313-461a-8ed2-6e128a2ae375 https://research.rug.nl/en/publications/1e44bd99-3313-461a-8ed2-6e128a2ae375 https://doi.org/10.1021/ac001428j https://pure.rug.nl/ws/files/6663577/2001AnalChemvTrigt.pdf |
genre |
ice core |
genre_facet |
ice core |
op_source |
van Trigt , R , Kerstel , E R T , Visser , GH & Meijer , H A J 2001 , ' Stable isotope ratio measurements on highly enriched water samples by means of laser spectrometry ' , Analytical Chemistry , vol. 73 , no. 11 , pp. 2445-2452 . https://doi.org/10.1021/ac001428j |
op_relation |
https://research.rug.nl/en/publications/1e44bd99-3313-461a-8ed2-6e128a2ae375 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1021/ac001428j |
container_title |
Analytical Chemistry |
container_volume |
73 |
container_issue |
11 |
container_start_page |
2445 |
op_container_end_page |
2452 |
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1800753316505845760 |