Concurrent decrease of vasopressin and protein kinase Cα immunoreactivity during the light phase in the vole suprachiasmatic nucleus
Vasopressin (AVP) is a major neuropeptide in the suprachiasmatic nucleus, the mammalian hypothalamic circadian pacemaker. Protein kinase Cα is a putatively coupled intracellular messenger. Mean numbers of AVP- and protein kinase Cα-immunoreactive neurons were determined in the suprachiasmatic nucleu...
Published in: | Neuroscience Letters |
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Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
1998
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Subjects: | |
Online Access: | https://hdl.handle.net/11370/1d4a990c-3e9d-48e2-a33f-6173b948d0a8 https://research.rug.nl/en/publications/1d4a990c-3e9d-48e2-a33f-6173b948d0a8 https://doi.org/10.1016/S0304-3940(98)00271-7 https://pure.rug.nl/ws/files/14659294/1998NeurosciLettJansen.pdf |
Summary: | Vasopressin (AVP) is a major neuropeptide in the suprachiasmatic nucleus, the mammalian hypothalamic circadian pacemaker. Protein kinase Cα is a putatively coupled intracellular messenger. Mean numbers of AVP- and protein kinase Cα-immunoreactive neurons were determined in the suprachiasmatic nucleus of common voles, entrained to a 12:12 h light-dark (LD) cycle, at the beginning of the light period (zeitgeber time zero) and 6 h later (zeitgeber time six). At zeitgeber time zero, mean numbers of AVP- and protein kinase Cα-immunoreactive neurons were 2194 and 9897, respectively. Both numbers decreased significantly with about 40% at zeitgeber time six. This concurrent decrease was most pronounced in the dorsomedial aspect of the suprachiasmatic nucleus. These findings are consistent with the findings of a peak of AVP release in rats during the early light phase. |
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