Multiple tumours in survival estimates.
International audience In international comparisons of cancer registry based survival it is common practice to restrict the analysis to first primary tumours and exclude multiple cancers. The probability of correctly detecting subsequent cancers depends on the registry's running time, which res...
Published in: | European Journal of Cancer |
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Online Access: | https://hal.science/hal-00492494 https://doi.org/10.1016/j.ejca.2008.11.030 |
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ftunifranchecom:oai:HAL:hal-00492494v1 2024-04-28T08:26:09+00:00 Multiple tumours in survival estimates. Rosso, Stefano de Angelis, Roberta Ciccolallo, Laura Carrani, Eugenio Soerjomataram, Isabelle Grande, Enrico Zigon, Giulia Brenner, Hermann Renseigné, Non Danzon, Arlette National Centre for Epidemiology, Surveillance and Health Promotion Istituto Superiore di Sanità = National Institute of Health (ISS) Evaluative Epidemiology Unit Fondazione IRCCS Division of Clinical Epidemiology and Aging Research German Cancer Research Center - Deutsches Krebsforschungszentrum Heidelberg (DKFZ) Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO) Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC) Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC) 2009-04 https://hal.science/hal-00492494 https://doi.org/10.1016/j.ejca.2008.11.030 en eng HAL CCSD Elsevier info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejca.2008.11.030 info:eu-repo/semantics/altIdentifier/pmid/19121933 hal-00492494 https://hal.science/hal-00492494 doi:10.1016/j.ejca.2008.11.030 PUBMED: 19121933 ISSN: 0959-8049 European Journal of Cancer https://hal.science/hal-00492494 European Journal of Cancer, 2009, 45 (6), pp.1080-1094. ⟨10.1016/j.ejca.2008.11.030⟩ MESH: Adolescent MESH: Adult MESH: Neoplasms Multiple Primary MESH: Sex Distribution MESH: Survival Analysis MESH: Young Adult MESH: Age Distribution MESH: Aged 80 and over MESH: Europe MESH: Female MESH: Humans MESH: Male MESH: Middle Aged [SDV.CAN]Life Sciences [q-bio]/Cancer info:eu-repo/semantics/article Journal articles 2009 ftunifranchecom https://doi.org/10.1016/j.ejca.2008.11.030 2024-04-10T23:44:04Z International audience In international comparisons of cancer registry based survival it is common practice to restrict the analysis to first primary tumours and exclude multiple cancers. The probability of correctly detecting subsequent cancers depends on the registry's running time, which results in different proportions of excluded patients and may lead to biased comparisons. We evaluated the impact on the age-standardised relative survival estimates of also including multiple primary tumours. Data from 2,919,023 malignant cancers from 69 European cancer registries participating in the EUROCARE-4 collaborative study were used. A total of 183,683 multiple primary tumours were found, with an overall proportion of 6.3% over all the considered cancers, ranging from 0.4% (Naples, Italy) to 12.9% (Iceland). The proportion of multiple tumours varied greatly by type of tumour, being higher for those with high incidence and long survival (breast, prostate and colon-rectum). Five-year relative survival was lower when including patients with multiple cancers. For all cancers combined the average difference was -0.4 percentage points in women and -0.7 percentage points in men, and was greater for older registries. Inclusion of multiple tumours led to lower survival in 44 out of 45 cancer sites analysed, with the greatest differences found for larynx (-1.9%), oropharynx (-1.5%), and penis (-1.3%). Including multiple primary tumours in survival estimates for international comparison is advisable because it reduces the bias due to different observation periods, age, registration quality and completeness of registration. The general effect of inclusion is to reduce survival estimates by a variable amount depending on the proportion of multiple primaries and cancer site. Article in Journal/Newspaper Iceland Université de Franche-Comté (UFC): HAL European Journal of Cancer 45 6 1080 1094 |
institution |
Open Polar |
collection |
Université de Franche-Comté (UFC): HAL |
op_collection_id |
ftunifranchecom |
language |
English |
topic |
MESH: Adolescent MESH: Adult MESH: Neoplasms Multiple Primary MESH: Sex Distribution MESH: Survival Analysis MESH: Young Adult MESH: Age Distribution MESH: Aged 80 and over MESH: Europe MESH: Female MESH: Humans MESH: Male MESH: Middle Aged [SDV.CAN]Life Sciences [q-bio]/Cancer |
spellingShingle |
MESH: Adolescent MESH: Adult MESH: Neoplasms Multiple Primary MESH: Sex Distribution MESH: Survival Analysis MESH: Young Adult MESH: Age Distribution MESH: Aged 80 and over MESH: Europe MESH: Female MESH: Humans MESH: Male MESH: Middle Aged [SDV.CAN]Life Sciences [q-bio]/Cancer Rosso, Stefano de Angelis, Roberta Ciccolallo, Laura Carrani, Eugenio Soerjomataram, Isabelle Grande, Enrico Zigon, Giulia Brenner, Hermann Renseigné, Non Danzon, Arlette Multiple tumours in survival estimates. |
topic_facet |
MESH: Adolescent MESH: Adult MESH: Neoplasms Multiple Primary MESH: Sex Distribution MESH: Survival Analysis MESH: Young Adult MESH: Age Distribution MESH: Aged 80 and over MESH: Europe MESH: Female MESH: Humans MESH: Male MESH: Middle Aged [SDV.CAN]Life Sciences [q-bio]/Cancer |
description |
International audience In international comparisons of cancer registry based survival it is common practice to restrict the analysis to first primary tumours and exclude multiple cancers. The probability of correctly detecting subsequent cancers depends on the registry's running time, which results in different proportions of excluded patients and may lead to biased comparisons. We evaluated the impact on the age-standardised relative survival estimates of also including multiple primary tumours. Data from 2,919,023 malignant cancers from 69 European cancer registries participating in the EUROCARE-4 collaborative study were used. A total of 183,683 multiple primary tumours were found, with an overall proportion of 6.3% over all the considered cancers, ranging from 0.4% (Naples, Italy) to 12.9% (Iceland). The proportion of multiple tumours varied greatly by type of tumour, being higher for those with high incidence and long survival (breast, prostate and colon-rectum). Five-year relative survival was lower when including patients with multiple cancers. For all cancers combined the average difference was -0.4 percentage points in women and -0.7 percentage points in men, and was greater for older registries. Inclusion of multiple tumours led to lower survival in 44 out of 45 cancer sites analysed, with the greatest differences found for larynx (-1.9%), oropharynx (-1.5%), and penis (-1.3%). Including multiple primary tumours in survival estimates for international comparison is advisable because it reduces the bias due to different observation periods, age, registration quality and completeness of registration. The general effect of inclusion is to reduce survival estimates by a variable amount depending on the proportion of multiple primaries and cancer site. |
author2 |
National Centre for Epidemiology, Surveillance and Health Promotion Istituto Superiore di Sanità = National Institute of Health (ISS) Evaluative Epidemiology Unit Fondazione IRCCS Division of Clinical Epidemiology and Aging Research German Cancer Research Center - Deutsches Krebsforschungszentrum Heidelberg (DKFZ) Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO) Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC) Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC) |
format |
Article in Journal/Newspaper |
author |
Rosso, Stefano de Angelis, Roberta Ciccolallo, Laura Carrani, Eugenio Soerjomataram, Isabelle Grande, Enrico Zigon, Giulia Brenner, Hermann Renseigné, Non Danzon, Arlette |
author_facet |
Rosso, Stefano de Angelis, Roberta Ciccolallo, Laura Carrani, Eugenio Soerjomataram, Isabelle Grande, Enrico Zigon, Giulia Brenner, Hermann Renseigné, Non Danzon, Arlette |
author_sort |
Rosso, Stefano |
title |
Multiple tumours in survival estimates. |
title_short |
Multiple tumours in survival estimates. |
title_full |
Multiple tumours in survival estimates. |
title_fullStr |
Multiple tumours in survival estimates. |
title_full_unstemmed |
Multiple tumours in survival estimates. |
title_sort |
multiple tumours in survival estimates. |
publisher |
HAL CCSD |
publishDate |
2009 |
url |
https://hal.science/hal-00492494 https://doi.org/10.1016/j.ejca.2008.11.030 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
ISSN: 0959-8049 European Journal of Cancer https://hal.science/hal-00492494 European Journal of Cancer, 2009, 45 (6), pp.1080-1094. ⟨10.1016/j.ejca.2008.11.030⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejca.2008.11.030 info:eu-repo/semantics/altIdentifier/pmid/19121933 hal-00492494 https://hal.science/hal-00492494 doi:10.1016/j.ejca.2008.11.030 PUBMED: 19121933 |
op_doi |
https://doi.org/10.1016/j.ejca.2008.11.030 |
container_title |
European Journal of Cancer |
container_volume |
45 |
container_issue |
6 |
container_start_page |
1080 |
op_container_end_page |
1094 |
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1797585652933459968 |