Sequence variant on 8q24 confers susceptibility to urinary bladder cancer
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs...
Published in: | Nature Genetics |
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2008
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Online Access: | http://hdl.handle.net/11584/182454 https://doi.org/10.1038/ng.229 |
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ftunicagliariris:oai:iris.unica.it:11584/182454 2024-04-21T08:05:43+00:00 Sequence variant on 8q24 confers susceptibility to urinary bladder cancer Kiemeney, Lambertus A. Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K. H. Stacey, Simon N. Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T. Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J. Alfred Vermeulen, Sita H. Hulsbergen Van De Kaa, Christina A. Swinkels, Dorine W. Ploeg, Martine Cornel, Erik B. Vergunst, Henk Thorgeirsson, Thorgeir E. Gudbjartsson, Daniel Gudjonsson, Sigurjon A. Thorleifsson, Gudmar Kristinsson, Kari T. Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta De Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D. Timothy Knowles, Margaret A. Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I. Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P. Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E. Gulcher, Jeffrey R. Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari CAMPAGNA, MARCELLO Kiemeney, Lambertus A. Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K. H. Stacey, Simon N. Gudmundsson, Juliu Jakobsdottir, Margret Bergthorsson, Jon T. Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J. Alfred Vermeulen, Sita H. Hulsbergen Van De Kaa, Christina A. Swinkels, Dorine W. Ploeg, Martine Cornel, Erik B. Vergunst, Henk Thorgeirsson, Thorgeir E. Gudbjartsson, Daniel Gudjonsson, Sigurjon A. Thorleifsson, Gudmar Kristinsson, Kari T. Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta De Verdier, Petra Lindblom, Annika Golka, Klau Bishop, D. Timothy Knowles, Margaret A. Nikulasson, Sigfu Petursdottir, Vigdi Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I. 2008 http://hdl.handle.net/11584/182454 https://doi.org/10.1038/ng.229 eng eng info:eu-repo/semantics/altIdentifier/pmid/18794855 info:eu-repo/semantics/altIdentifier/wos/WOS:000260501500022 volume:40 issue:11 firstpage:1307 lastpage:1312 numberofpages:6 journal:NATURE GENETICS http://hdl.handle.net/11584/182454 doi:10.1038/ng.229 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-55049112064 Adult Aged 80 and over Base Sequence Case-Control Studie Chromosomes Human Pair 3 Pair 8 Female Genetic Marker Linkage Disequilibrium Male Middle Aged Mutation Urinary Bladder Neoplasm Genetic Predisposition to Disease Medicine (all) Genetics info:eu-repo/semantics/article 2008 ftunicagliariris https://doi.org/10.1038/ng.229 2024-03-25T16:07:14Z We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 × 10-12). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 × 10-7). © 2008 Nature Publishing Group. Article in Journal/Newspaper Iceland Università degli Studi di Cagliari: UNICA IRIS Nature Genetics 40 11 1307 1312 |
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Università degli Studi di Cagliari: UNICA IRIS |
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ftunicagliariris |
language |
English |
topic |
Adult Aged 80 and over Base Sequence Case-Control Studie Chromosomes Human Pair 3 Pair 8 Female Genetic Marker Linkage Disequilibrium Male Middle Aged Mutation Urinary Bladder Neoplasm Genetic Predisposition to Disease Medicine (all) Genetics |
spellingShingle |
Adult Aged 80 and over Base Sequence Case-Control Studie Chromosomes Human Pair 3 Pair 8 Female Genetic Marker Linkage Disequilibrium Male Middle Aged Mutation Urinary Bladder Neoplasm Genetic Predisposition to Disease Medicine (all) Genetics Kiemeney, Lambertus A. Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K. H. Stacey, Simon N. Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T. Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J. Alfred Vermeulen, Sita H. Hulsbergen Van De Kaa, Christina A. Swinkels, Dorine W. Ploeg, Martine Cornel, Erik B. Vergunst, Henk Thorgeirsson, Thorgeir E. Gudbjartsson, Daniel Gudjonsson, Sigurjon A. Thorleifsson, Gudmar Kristinsson, Kari T. Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta De Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D. Timothy Knowles, Margaret A. Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I. Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P. Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E. Gulcher, Jeffrey R. Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari CAMPAGNA, MARCELLO Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
topic_facet |
Adult Aged 80 and over Base Sequence Case-Control Studie Chromosomes Human Pair 3 Pair 8 Female Genetic Marker Linkage Disequilibrium Male Middle Aged Mutation Urinary Bladder Neoplasm Genetic Predisposition to Disease Medicine (all) Genetics |
description |
We conducted a genome-wide SNP association study on 1,803 urinary bladder cancer (UBC) cases and 34,336 controls from Iceland and The Netherlands and follow up studies in seven additional case-control groups (2,165 cases and 3,800 controls). The strongest association was observed with allele T of rs9642880 on chromosome 8q24, 30 kb upstream of MYC (allele-specific odds ratio (OR) = 1.22; P = 9.34 × 10-12). Approximately 20% of individuals of European ancestry are homozygous for rs9642880[T], and their estimated risk of developing UBC is 1.49 times that of noncarriers. No association was observed between UBC and the four 8q24 variants previously associated with prostate, colorectal and breast cancers, nor did rs9642880 associate with any of these three cancers. A weaker signal, but nonetheless of genome-wide significance, was captured by rs710521[A] located near TP63 on chromosome 3q28 (allele-specific OR = 1.19; P = 1. 15 × 10-7). © 2008 Nature Publishing Group. |
author2 |
Kiemeney, Lambertus A. Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K. H. Stacey, Simon N. Gudmundsson, Juliu Jakobsdottir, Margret Bergthorsson, Jon T. Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J. Alfred Vermeulen, Sita H. Hulsbergen Van De Kaa, Christina A. Swinkels, Dorine W. Ploeg, Martine Cornel, Erik B. Vergunst, Henk Thorgeirsson, Thorgeir E. Gudbjartsson, Daniel Gudjonsson, Sigurjon A. Thorleifsson, Gudmar Kristinsson, Kari T. Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Campagna, Marcello Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta De Verdier, Petra Lindblom, Annika Golka, Klau Bishop, D. Timothy Knowles, Margaret A. Nikulasson, Sigfu Petursdottir, Vigdi Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I. |
format |
Article in Journal/Newspaper |
author |
Kiemeney, Lambertus A. Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K. H. Stacey, Simon N. Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T. Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J. Alfred Vermeulen, Sita H. Hulsbergen Van De Kaa, Christina A. Swinkels, Dorine W. Ploeg, Martine Cornel, Erik B. Vergunst, Henk Thorgeirsson, Thorgeir E. Gudbjartsson, Daniel Gudjonsson, Sigurjon A. Thorleifsson, Gudmar Kristinsson, Kari T. Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta De Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D. Timothy Knowles, Margaret A. Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I. Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P. Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E. Gulcher, Jeffrey R. Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari CAMPAGNA, MARCELLO |
author_facet |
Kiemeney, Lambertus A. Thorlacius, Steinunn Sulem, Patrick Geller, Frank Aben, Katja K. H. Stacey, Simon N. Gudmundsson, Julius Jakobsdottir, Margret Bergthorsson, Jon T. Sigurdsson, Asgeir Blondal, Thorarinn Witjes, J. Alfred Vermeulen, Sita H. Hulsbergen Van De Kaa, Christina A. Swinkels, Dorine W. Ploeg, Martine Cornel, Erik B. Vergunst, Henk Thorgeirsson, Thorgeir E. Gudbjartsson, Daniel Gudjonsson, Sigurjon A. Thorleifsson, Gudmar Kristinsson, Kari T. Mouy, Magali Snorradottir, Steinunn Placidi, Donatella Arici, Cecilia Koppova, Kvetoslava Gurzau, Eugene Rudnai, Peter Kellen, Eliane Polidoro, Silvia Guarrera, Simonetta Sacerdote, Carlotta Sanchez, Manuel Saez, Berta Valdivia, Gabriel Ryk, Charlotta De Verdier, Petra Lindblom, Annika Golka, Klaus Bishop, D. Timothy Knowles, Margaret A. Nikulasson, Sigfus Petursdottir, Vigdis Jonsson, Eirikur Geirsson, Gudmundur Kristjansson, Baldvin Mayordomo, Jose I. Steineck, Gunnar Porru, Stefano Buntinx, Frank Zeegers, Maurice P. Fletcher, Tony Kumar, Rajiv Matullo, Giuseppe Vineis, Paolo Kiltie, Anne E. Gulcher, Jeffrey R. Thorsteinsdottir, Unnur Kong, Augustine Rafnar, Thorunn Stefansson, Kari CAMPAGNA, MARCELLO |
author_sort |
Kiemeney, Lambertus A. |
title |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_short |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_full |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_fullStr |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_full_unstemmed |
Sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
title_sort |
sequence variant on 8q24 confers susceptibility to urinary bladder cancer |
publishDate |
2008 |
url |
http://hdl.handle.net/11584/182454 https://doi.org/10.1038/ng.229 |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/18794855 info:eu-repo/semantics/altIdentifier/wos/WOS:000260501500022 volume:40 issue:11 firstpage:1307 lastpage:1312 numberofpages:6 journal:NATURE GENETICS http://hdl.handle.net/11584/182454 doi:10.1038/ng.229 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-55049112064 |
op_doi |
https://doi.org/10.1038/ng.229 |
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Nature Genetics |
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1307 |
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1312 |
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1796945126505840640 |