86. Lipase-catalysed regioselective deacetylation of androstane derivatives
A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards...
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| Online Access: | https://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari |
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ftunibueairesbd:todo:paper_0018019X_v79_n4_p999_Baldessari 2023-10-29T02:30:31+01:00 86. Lipase-catalysed regioselective deacetylation of androstane derivatives Baldessari, A. Bruttomesso, A.C. Gros, E.G. https://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari unknown http://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar androstane derivative triacylglycerol lipase article drug synthesis enzyme activity nuclear magnetic resonance reaction analysis stereochemistry technique JOUR ftunibueairesbd https://doi.org/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari 2023-10-05T01:56:34Z A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards the removal of the 3β - or the 17β-acetyl group (see Table 2). Three new steroid derivatives were obtained through this approach. A hypothetical rationale for the behaviour of these enzymes is given. Journal/Newspaper Antarc* Antarctica Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires) |
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Open Polar |
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Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires) |
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ftunibueairesbd |
| language |
unknown |
| topic |
androstane derivative triacylglycerol lipase article drug synthesis enzyme activity nuclear magnetic resonance reaction analysis stereochemistry technique |
| spellingShingle |
androstane derivative triacylglycerol lipase article drug synthesis enzyme activity nuclear magnetic resonance reaction analysis stereochemistry technique Baldessari, A. Bruttomesso, A.C. Gros, E.G. 86. Lipase-catalysed regioselective deacetylation of androstane derivatives |
| topic_facet |
androstane derivative triacylglycerol lipase article drug synthesis enzyme activity nuclear magnetic resonance reaction analysis stereochemistry technique |
| description |
A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards the removal of the 3β - or the 17β-acetyl group (see Table 2). Three new steroid derivatives were obtained through this approach. A hypothetical rationale for the behaviour of these enzymes is given. |
| format |
Journal/Newspaper |
| author |
Baldessari, A. Bruttomesso, A.C. Gros, E.G. |
| author_facet |
Baldessari, A. Bruttomesso, A.C. Gros, E.G. |
| author_sort |
Baldessari, A. |
| title |
86. Lipase-catalysed regioselective deacetylation of androstane derivatives |
| title_short |
86. Lipase-catalysed regioselective deacetylation of androstane derivatives |
| title_full |
86. Lipase-catalysed regioselective deacetylation of androstane derivatives |
| title_fullStr |
86. Lipase-catalysed regioselective deacetylation of androstane derivatives |
| title_full_unstemmed |
86. Lipase-catalysed regioselective deacetylation of androstane derivatives |
| title_sort |
86. lipase-catalysed regioselective deacetylation of androstane derivatives |
| url |
https://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari |
| genre |
Antarc* Antarctica |
| genre_facet |
Antarc* Antarctica |
| op_relation |
http://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari |
| op_rights |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/2.5/ar |
| op_doi |
https://doi.org/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari |
| _version_ |
1781059210428022784 |