Regioselective enzymatic synthesis of estradiol 17-fatty acid esters

• Main Authors: Rustoy, Eduardo Miguel, Baldessari, Alicia
• Language: unknown
• Published: 2005
• Subjects: 3,17-β-estradiol esters; Enzymatic acylation and alcoholysis; Lipases; Argentina; Rugosa; Antarc*; Antarctica
• Online Access: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_14246376_v2005_n12_p175_Rustoy; https://hdl.handle.net/20.500.12110/paper_14246376_v2005_n12_p175_Rustoy

A series of acyl esters of 3,17-β-estradiol has been prepared by an enzymatic methodology. Eleven 17-monoacyl products (five novel compounds) were obtained in a highly regioselective way by acylation of 3,17-β-estradiol or by alcoholysis of the corresponding diacyl derivatives. The influence of vari...