Lipases as catalysts in synthesis of fine chemicals

• Language: unknown
• Published: 2012
• Subjects: Alfuzosin; Esterification and aminolysis reactions; Fine chemicals; Lapyrium chloride; Lipases; acetic acid derivative; biological product; chloroacetic acid; diamine; fungal protein; furan derivative; lapyrium; lipase B; Candida antarctica; pyridinium derivative; quinazoline derivative; triacylglycerol lipase; article; biocatalysis; Candida; chemistry; green chemistry; synthesis; Acetic Acids; Biological Agents; Diamines; Fungal Proteins; Furans; Green Chemistry Technology; Lipase; Pyridinium Compounds; Quinazolines; Antarc*; Antarctica
• Online Access: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_10643745_v861_n_p445_Baldessari; https://hdl.handle.net/20.500.12110/paper_10643745_v861_n_p445_Baldessari

The application of lipases as catalysts in the synthesis of an intermediate of alfuzosin and lapyrium chloride is described. In the first case, the one-pot procedure to obtain the intermediate involves the treatment of tetrahydrofuroic acid with ethanol in the presence of Candida antarctica lipase followed by the addition of N-methyl-1,3-diaminopropane. In the second part of the chapter, an efficient route for large-scale preparation of lapyrium chloride is developed from chloroacetic acid in four steps, three of them enzymatic. Due to the chemoselective behavior of the lipases, both products described in the present chapter were obtained in a high degree of purity and yield, applying mild reaction conditions, and following a low environmental impact methodology. © 2012 Springer Science+Business Media New York.