86. Lipase-catalysed regioselective deacetylation of androstane derivatives

A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards...

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Bibliographic Details
Language:unknown
Published: 1996
Subjects:
androstane derivative
triacylglycerol lipase
article
drug synthesis
enzyme activity
nuclear magnetic resonance
reaction analysis
stereochemistry
technique
Antarc*
Antarctica
Online Access:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v79_n4_p999_Baldessari
https://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari
id ftunibueairesbd:paper:paper_0018019X_v79_n4_p999_Baldessari
record_format openpolar
spelling ftunibueairesbd:paper:paper_0018019X_v79_n4_p999_Baldessari 2023-05-15T13:42:26+02:00 86. Lipase-catalysed regioselective deacetylation of androstane derivatives 1996 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v79_n4_p999_Baldessari https://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari unknown https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v79_n4_p999_Baldessari http://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari androstane derivative triacylglycerol lipase article drug synthesis enzyme activity nuclear magnetic resonance reaction analysis stereochemistry technique 1996 ftunibueairesbd https://doi.org/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari 2023-02-16T02:02:54Z A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards the removal of the 3β - or the 17β-acetyl group (see Table 2). Three new steroid derivatives were obtained through this approach. A hypothetical rationale for the behaviour of these enzymes is given. Other/Unknown Material Antarc* Antarctica Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
institution Open Polar
collection Biblioteca Digital FCEN-UBA (Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires)
op_collection_id ftunibueairesbd
language unknown
topic androstane derivative
triacylglycerol lipase
article
drug synthesis
enzyme activity
nuclear magnetic resonance
reaction analysis
stereochemistry
technique
spellingShingle androstane derivative
triacylglycerol lipase
article
drug synthesis
enzyme activity
nuclear magnetic resonance
reaction analysis
stereochemistry
technique
86. Lipase-catalysed regioselective deacetylation of androstane derivatives
topic_facet androstane derivative
triacylglycerol lipase
article
drug synthesis
enzyme activity
nuclear magnetic resonance
reaction analysis
stereochemistry
technique
description A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (CAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards the removal of the 3β - or the 17β-acetyl group (see Table 2). Three new steroid derivatives were obtained through this approach. A hypothetical rationale for the behaviour of these enzymes is given.
title 86. Lipase-catalysed regioselective deacetylation of androstane derivatives
title_short 86. Lipase-catalysed regioselective deacetylation of androstane derivatives
title_full 86. Lipase-catalysed regioselective deacetylation of androstane derivatives
title_fullStr 86. Lipase-catalysed regioselective deacetylation of androstane derivatives
title_full_unstemmed 86. Lipase-catalysed regioselective deacetylation of androstane derivatives
title_sort 86. lipase-catalysed regioselective deacetylation of androstane derivatives
publishDate 1996
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v79_n4_p999_Baldessari
https://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari
genre Antarc*
Antarctica
genre_facet Antarc*
Antarctica
op_relation https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0018019X_v79_n4_p999_Baldessari
http://hdl.handle.net/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari
op_doi https://doi.org/20.500.12110/paper_0018019X_v79_n4_p999_Baldessari
_version_ 1766167846863241216

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