Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution
Among Metazoa, bivalves have the highest lifespan disparity, ranging from 1 to 500+ years, making them an exceptional testing ground to understand mechanisms underlying aging and the evolution of extended longevity. Nevertheless, comparative molecular evolution has been an overlooked approach in thi...
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ftunibolognairis:oai:cris.unibo.it:11585/951354 2024-05-19T07:36:55+00:00 Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution Iannello M. Forni G. Piccinini G. Xu R. Martelossi J. Ghiselli F. Milani L. Iannello M. Forni G. Piccinini G. Xu R. Martelossi J. Ghiselli F. Milani L. 2023 ELETTRONICO https://hdl.handle.net/11585/951354 https://doi.org/10.1093/gbe/evad159 https://academic.oup.com/gbe/article/15/11/evad159/7255996 eng eng info:eu-repo/semantics/altIdentifier/pmid/37647860 info:eu-repo/semantics/altIdentifier/wos/WOS:001106049500002 volume:15 issue:11 firstpage:1 lastpage:17 numberofpages:17 journal:GENOME BIOLOGY AND EVOLUTION https://hdl.handle.net/11585/951354 doi:10.1093/gbe/evad159 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85177103911 https://academic.oup.com/gbe/article/15/11/evad159/7255996 info:eu-repo/semantics/openAccess aging cell proliferation convergent evolution hypoxia response senescence info:eu-repo/semantics/article 2023 ftunibolognairis https://doi.org/10.1093/gbe/evad159 2024-04-26T00:17:50Z Among Metazoa, bivalves have the highest lifespan disparity, ranging from 1 to 500+ years, making them an exceptional testing ground to understand mechanisms underlying aging and the evolution of extended longevity. Nevertheless, comparative molecular evolution has been an overlooked approach in this instance. Here, we leveraged transcriptomic resources spanning 30 bivalve species to unravel the signatures of convergent molecular evolution in four long-lived species: Margaritifera margaritifera, Elliptio complanata, Lampsilis siliquoidea, and Arctica islandica (the latter represents the longest-lived noncolonial metazoan known so far). We applied a comprehensive approach-which included inference of convergent dN/dS, convergent positive selection, and convergent amino acid substitution-with a strong focus on the reduction of false positives. Genes with convergent evolution in long-lived bivalves show more physical and functional interactions to each other than expected, suggesting that they are biologically connected; this interaction network is enriched in genes for which a role in longevity has been experimentally supported in other species. This suggests that genes in the network are involved in extended longevity in bivalves and, consequently, that the mechanisms underlying extended longevity are-at least partially-shared across Metazoa. Although we believe that an integration of different genes and pathways is required for the extended longevity phenotype, we highlight the potential central roles of genes involved in cell proliferation control, translational machinery, and response to hypoxia, in lifespan extension. Article in Journal/Newspaper Arctica islandica IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) Genome Biology and Evolution 15 11 |
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Open Polar |
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IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
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ftunibolognairis |
language |
English |
topic |
aging cell proliferation convergent evolution hypoxia response senescence |
spellingShingle |
aging cell proliferation convergent evolution hypoxia response senescence Iannello M. Forni G. Piccinini G. Xu R. Martelossi J. Ghiselli F. Milani L. Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
topic_facet |
aging cell proliferation convergent evolution hypoxia response senescence |
description |
Among Metazoa, bivalves have the highest lifespan disparity, ranging from 1 to 500+ years, making them an exceptional testing ground to understand mechanisms underlying aging and the evolution of extended longevity. Nevertheless, comparative molecular evolution has been an overlooked approach in this instance. Here, we leveraged transcriptomic resources spanning 30 bivalve species to unravel the signatures of convergent molecular evolution in four long-lived species: Margaritifera margaritifera, Elliptio complanata, Lampsilis siliquoidea, and Arctica islandica (the latter represents the longest-lived noncolonial metazoan known so far). We applied a comprehensive approach-which included inference of convergent dN/dS, convergent positive selection, and convergent amino acid substitution-with a strong focus on the reduction of false positives. Genes with convergent evolution in long-lived bivalves show more physical and functional interactions to each other than expected, suggesting that they are biologically connected; this interaction network is enriched in genes for which a role in longevity has been experimentally supported in other species. This suggests that genes in the network are involved in extended longevity in bivalves and, consequently, that the mechanisms underlying extended longevity are-at least partially-shared across Metazoa. Although we believe that an integration of different genes and pathways is required for the extended longevity phenotype, we highlight the potential central roles of genes involved in cell proliferation control, translational machinery, and response to hypoxia, in lifespan extension. |
author2 |
Iannello M. Forni G. Piccinini G. Xu R. Martelossi J. Ghiselli F. Milani L. |
format |
Article in Journal/Newspaper |
author |
Iannello M. Forni G. Piccinini G. Xu R. Martelossi J. Ghiselli F. Milani L. |
author_facet |
Iannello M. Forni G. Piccinini G. Xu R. Martelossi J. Ghiselli F. Milani L. |
author_sort |
Iannello M. |
title |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_short |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_full |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_fullStr |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_full_unstemmed |
Signatures of Extreme Longevity: A Perspective from Bivalve Molecular Evolution |
title_sort |
signatures of extreme longevity: a perspective from bivalve molecular evolution |
publishDate |
2023 |
url |
https://hdl.handle.net/11585/951354 https://doi.org/10.1093/gbe/evad159 https://academic.oup.com/gbe/article/15/11/evad159/7255996 |
genre |
Arctica islandica |
genre_facet |
Arctica islandica |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/37647860 info:eu-repo/semantics/altIdentifier/wos/WOS:001106049500002 volume:15 issue:11 firstpage:1 lastpage:17 numberofpages:17 journal:GENOME BIOLOGY AND EVOLUTION https://hdl.handle.net/11585/951354 doi:10.1093/gbe/evad159 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85177103911 https://academic.oup.com/gbe/article/15/11/evad159/7255996 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1093/gbe/evad159 |
container_title |
Genome Biology and Evolution |
container_volume |
15 |
container_issue |
11 |
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1799476068214636544 |