Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype
Rotavirus is one of the leading causes of acute gastroenteritis in infants and young children. RVAs infect not only humans but also a wide range of mammals including rats, which represent a reservoir of several other zoonotic pathogens. Due to the segmented nature of the RVA genome, animal RVA strai...
Published in: | Infection, Genetics and Evolution |
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Online Access: | http://hdl.handle.net/11585/602019 https://doi.org/10.1016/j.meegid.2017.06.008 |
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ftunibolognairis:oai:cris.unibo.it:11585/602019 2024-04-14T08:18:43+00:00 Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype Ianiro, Giovanni Di Bartolo, Ilaria De Sabato, Luca Pampiglione, Guglielmo Ruggeri, Franco M OSTANELLO, FABIO Ianiro, Giovanni Di Bartolo, Ilaria De Sabato, Luca Pampiglione, Guglielmo Ruggeri, Franco M Ostanello, Fabio 2017 STAMPA http://hdl.handle.net/11585/602019 https://doi.org/10.1016/j.meegid.2017.06.008 eng eng info:eu-repo/semantics/altIdentifier/pmid/28603021 info:eu-repo/semantics/altIdentifier/wos/WOS:000404559400027 volume:53 firstpage:206 lastpage:211 numberofpages:6 journal:INFECTION GENETICS AND EVOLUTION http://hdl.handle.net/11585/602019 doi:10.1016/j.meegid.2017.06.008 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85020699146 G3P[3] Group A rotaviru Italy NSP2 Rat Reassortment info:eu-repo/semantics/article 2017 ftunibolognairis https://doi.org/10.1016/j.meegid.2017.06.008 2024-03-21T17:43:18Z Rotavirus is one of the leading causes of acute gastroenteritis in infants and young children. RVAs infect not only humans but also a wide range of mammals including rats, which represent a reservoir of several other zoonotic pathogens. Due to the segmented nature of the RVA genome, animal RVA strains can easily adapt to the human host by reassortment with co-infecting human viruses. This study aims to detect and characterize RVA in the intestinal content of Italian sinantropic rats (Rattus rattus). Out of 40 samples examined following molecular approach, one resulted positive for RVA. The molecular characterization of VP1-4, 6 and 7, and NSP1-5 genes by sequencing revealed the genomic constellation G3-P[3]-I1-R11-C11-M10-A22-N18-T14-E18-H13. This uncommon genomic combination includes: the VP1-4,VP7, the NSP1, 3, 4 and 5 gene segments, closely related to those of RVA from rodents, the N18 novel genotype established for the NSP2 gene segment and the human Wa-like VP6 gene, suggesting interspecies reassortment. Article in Journal/Newspaper Rattus rattus IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) Infection, Genetics and Evolution 53 206 211 |
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Open Polar |
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IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
op_collection_id |
ftunibolognairis |
language |
English |
topic |
G3P[3] Group A rotaviru Italy NSP2 Rat Reassortment |
spellingShingle |
G3P[3] Group A rotaviru Italy NSP2 Rat Reassortment Ianiro, Giovanni Di Bartolo, Ilaria De Sabato, Luca Pampiglione, Guglielmo Ruggeri, Franco M OSTANELLO, FABIO Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype |
topic_facet |
G3P[3] Group A rotaviru Italy NSP2 Rat Reassortment |
description |
Rotavirus is one of the leading causes of acute gastroenteritis in infants and young children. RVAs infect not only humans but also a wide range of mammals including rats, which represent a reservoir of several other zoonotic pathogens. Due to the segmented nature of the RVA genome, animal RVA strains can easily adapt to the human host by reassortment with co-infecting human viruses. This study aims to detect and characterize RVA in the intestinal content of Italian sinantropic rats (Rattus rattus). Out of 40 samples examined following molecular approach, one resulted positive for RVA. The molecular characterization of VP1-4, 6 and 7, and NSP1-5 genes by sequencing revealed the genomic constellation G3-P[3]-I1-R11-C11-M10-A22-N18-T14-E18-H13. This uncommon genomic combination includes: the VP1-4,VP7, the NSP1, 3, 4 and 5 gene segments, closely related to those of RVA from rodents, the N18 novel genotype established for the NSP2 gene segment and the human Wa-like VP6 gene, suggesting interspecies reassortment. |
author2 |
Ianiro, Giovanni Di Bartolo, Ilaria De Sabato, Luca Pampiglione, Guglielmo Ruggeri, Franco M Ostanello, Fabio |
format |
Article in Journal/Newspaper |
author |
Ianiro, Giovanni Di Bartolo, Ilaria De Sabato, Luca Pampiglione, Guglielmo Ruggeri, Franco M OSTANELLO, FABIO |
author_facet |
Ianiro, Giovanni Di Bartolo, Ilaria De Sabato, Luca Pampiglione, Guglielmo Ruggeri, Franco M OSTANELLO, FABIO |
author_sort |
Ianiro, Giovanni |
title |
Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype |
title_short |
Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype |
title_full |
Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype |
title_fullStr |
Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype |
title_full_unstemmed |
Detection of uncommon G3P[3] rotavirus A (RVA) strain in rat possessing a human RVA-like VP6 and a novel NSP2 genotype |
title_sort |
detection of uncommon g3p[3] rotavirus a (rva) strain in rat possessing a human rva-like vp6 and a novel nsp2 genotype |
publishDate |
2017 |
url |
http://hdl.handle.net/11585/602019 https://doi.org/10.1016/j.meegid.2017.06.008 |
genre |
Rattus rattus |
genre_facet |
Rattus rattus |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/28603021 info:eu-repo/semantics/altIdentifier/wos/WOS:000404559400027 volume:53 firstpage:206 lastpage:211 numberofpages:6 journal:INFECTION GENETICS AND EVOLUTION http://hdl.handle.net/11585/602019 doi:10.1016/j.meegid.2017.06.008 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85020699146 |
op_doi |
https://doi.org/10.1016/j.meegid.2017.06.008 |
container_title |
Infection, Genetics and Evolution |
container_volume |
53 |
container_start_page |
206 |
op_container_end_page |
211 |
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1796318251147329536 |