MHC variability in an isolated wolf population in Italy.
Small, isolated populations may experience increased extinction risk due to reduced genetic variability at important functional genes, thus decreasing the population's adaptive potential. The major histocompatibility complex (MHC), a key immunological gene cluster, usually shows high variabilit...
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Online Access: | http://hdl.handle.net/11585/400556 https://doi.org/10.1093/jhered/est045 |
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ftunibolognairis:oai:cris.unibo.it:11585/400556 2024-09-15T18:01:19+00:00 MHC variability in an isolated wolf population in Italy. GALAVERNI, MARCO CANIGLIA, ROMOLO LAPALOMBELLA, SILVANA RANDI, ETTORE Fabbri E Galaverni M Caniglia R Fabbri E Lapalombella S Randi E 2013 ELETTRONICO http://hdl.handle.net/11585/400556 https://doi.org/10.1093/jhered/est045 eng eng info:eu-repo/semantics/altIdentifier/pmid/23885092 info:eu-repo/semantics/altIdentifier/wos/WOS:000323294400002 volume:104 issue:5 firstpage:601 lastpage:613 numberofpages:12 journal:JOURNAL OF HEREDITY http://hdl.handle.net/11585/400556 doi:10.1093/jhered/est045 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84882759054 CANIS LUPUS MHC phylogenetic bottleneck HYBRIDIZATION MAJOR HISTOCOMPATIBILITY COMPLEX NATURAL SELECTION info:eu-repo/semantics/article 2013 ftunibolognairis https://doi.org/10.1093/jhered/est045 2024-07-01T14:08:30Z Small, isolated populations may experience increased extinction risk due to reduced genetic variability at important functional genes, thus decreasing the population's adaptive potential. The major histocompatibility complex (MHC), a key immunological gene cluster, usually shows high variability maintained by positive or balancing selection in response to challenges by pathogens. Here we investigated for the first time, the variability of 3 MHC class II genes (DRB1, DQA1, and DQB1) in 94 samples collected from Italian wolves. The Italian wolf population has been long isolated south of the Alps and is presently recovering from a recent bottleneck that decreased the population to less than 100 individuals. Despite the bottleneck, Italian wolves show remarkable MHC variability with 6-9 alleles per locus, including 2 recently described alleles at DRB1. MHC sequences show signatures of historical selective pressures (high d N/d S ratio, ω > 1.74) but no evidence of ongoing selection. Variation at the MHC genes and 12 background microsatellite loci were not apparently affected by the recent bottleneck. Although MHC alleles of domestic dog origin were detected in 8 genetically admixed individuals, these alleles were rare or absent in nonadmixed wolves. Thus, despite known hybridization events between domestic dogs and Italian wolves, the Italian wolf population does not appear affected by deep introgression of domestic dog MHC alleles. Article in Journal/Newspaper Canis lupus IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) Journal of Heredity 104 5 601 612 |
institution |
Open Polar |
collection |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
op_collection_id |
ftunibolognairis |
language |
English |
topic |
CANIS LUPUS MHC phylogenetic bottleneck HYBRIDIZATION MAJOR HISTOCOMPATIBILITY COMPLEX NATURAL SELECTION |
spellingShingle |
CANIS LUPUS MHC phylogenetic bottleneck HYBRIDIZATION MAJOR HISTOCOMPATIBILITY COMPLEX NATURAL SELECTION GALAVERNI, MARCO CANIGLIA, ROMOLO LAPALOMBELLA, SILVANA RANDI, ETTORE Fabbri E MHC variability in an isolated wolf population in Italy. |
topic_facet |
CANIS LUPUS MHC phylogenetic bottleneck HYBRIDIZATION MAJOR HISTOCOMPATIBILITY COMPLEX NATURAL SELECTION |
description |
Small, isolated populations may experience increased extinction risk due to reduced genetic variability at important functional genes, thus decreasing the population's adaptive potential. The major histocompatibility complex (MHC), a key immunological gene cluster, usually shows high variability maintained by positive or balancing selection in response to challenges by pathogens. Here we investigated for the first time, the variability of 3 MHC class II genes (DRB1, DQA1, and DQB1) in 94 samples collected from Italian wolves. The Italian wolf population has been long isolated south of the Alps and is presently recovering from a recent bottleneck that decreased the population to less than 100 individuals. Despite the bottleneck, Italian wolves show remarkable MHC variability with 6-9 alleles per locus, including 2 recently described alleles at DRB1. MHC sequences show signatures of historical selective pressures (high d N/d S ratio, ω > 1.74) but no evidence of ongoing selection. Variation at the MHC genes and 12 background microsatellite loci were not apparently affected by the recent bottleneck. Although MHC alleles of domestic dog origin were detected in 8 genetically admixed individuals, these alleles were rare or absent in nonadmixed wolves. Thus, despite known hybridization events between domestic dogs and Italian wolves, the Italian wolf population does not appear affected by deep introgression of domestic dog MHC alleles. |
author2 |
Galaverni M Caniglia R Fabbri E Lapalombella S Randi E |
format |
Article in Journal/Newspaper |
author |
GALAVERNI, MARCO CANIGLIA, ROMOLO LAPALOMBELLA, SILVANA RANDI, ETTORE Fabbri E |
author_facet |
GALAVERNI, MARCO CANIGLIA, ROMOLO LAPALOMBELLA, SILVANA RANDI, ETTORE Fabbri E |
author_sort |
GALAVERNI, MARCO |
title |
MHC variability in an isolated wolf population in Italy. |
title_short |
MHC variability in an isolated wolf population in Italy. |
title_full |
MHC variability in an isolated wolf population in Italy. |
title_fullStr |
MHC variability in an isolated wolf population in Italy. |
title_full_unstemmed |
MHC variability in an isolated wolf population in Italy. |
title_sort |
mhc variability in an isolated wolf population in italy. |
publishDate |
2013 |
url |
http://hdl.handle.net/11585/400556 https://doi.org/10.1093/jhered/est045 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/23885092 info:eu-repo/semantics/altIdentifier/wos/WOS:000323294400002 volume:104 issue:5 firstpage:601 lastpage:613 numberofpages:12 journal:JOURNAL OF HEREDITY http://hdl.handle.net/11585/400556 doi:10.1093/jhered/est045 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84882759054 |
op_doi |
https://doi.org/10.1093/jhered/est045 |
container_title |
Journal of Heredity |
container_volume |
104 |
container_issue |
5 |
container_start_page |
601 |
op_container_end_page |
612 |
_version_ |
1810438481502011392 |