Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study
The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer...
Published in: | International Journal of Cancer |
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2021
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Online Access: | https://pure.au.dk/portal/en/publications/fc7d292f-dc22-4155-b2a3-95d84bc49a4b https://doi.org/10.1002/ijc.33741 https://pure.au.dk/ws/files/274237614/Intl_Journal_of_Cancer_2021_Oskarsson_Skeletal_adverse_events_in_childhood_cancer_survivors_An_Adult_Life_after.pdf http://www.scopus.com/inward/record.url?scp=85111998976&partnerID=8YFLogxK |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/fc7d292f-dc22-4155-b2a3-95d84bc49a4b 2024-06-23T07:54:08+00:00 Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck 2021-12 application/pdf https://pure.au.dk/portal/en/publications/fc7d292f-dc22-4155-b2a3-95d84bc49a4b https://doi.org/10.1002/ijc.33741 https://pure.au.dk/ws/files/274237614/Intl_Journal_of_Cancer_2021_Oskarsson_Skeletal_adverse_events_in_childhood_cancer_survivors_An_Adult_Life_after.pdf http://www.scopus.com/inward/record.url?scp=85111998976&partnerID=8YFLogxK eng eng https://pure.au.dk/portal/en/publications/fc7d292f-dc22-4155-b2a3-95d84bc49a4b info:eu-repo/semantics/openAccess Oskarsson , T , Duun-Henriksen , A K , Bautz , A , Montgomery , S , Harila-Saari , A , Petersen , C , Niinimäki , R , Madanat-Harjuoja , L , Tryggvadóttir , L , Holmqvist , A S , Hasle , H , Heyman , M , Winther , J F & ALiCCS Study Group 2021 , ' Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study ' , International Journal of Cancer , vol. 149 , no. 11 , pp. 1863-1876 . https://doi.org/10.1002/ijc.33741 ALiCCS childhood cancer late effects skeletal adverse events survivorship YOUNG-ADULTS LONG-TERM SURVIVORS RISK-FACTORS BONE-MINERAL DENSITY OSTEONECROSIS CHILDREN ACUTE LYMPHOBLASTIC-LEUKEMIA PEDIATRIC-PATIENTS FRACTURES LYMPHOMA Bone Diseases/epidemiology Humans Child Preschool Infant Male Risk Scandinavian and Nordic Countries/epidemiology Young Adult Registries/statistics & numerical data Female Hospitalization/statistics & numerical data Neoplasms/epidemiology Cancer Survivors/statistics & numerical data Bone/epidemiology Adolescent Cohort Studies article 2021 ftuniaarhuspubl https://doi.org/10.1002/ijc.33741 2024-06-04T14:34:42Z The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. Article in Journal/Newspaper Iceland Aarhus University: Research International Journal of Cancer 149 11 1863 1876 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
ALiCCS childhood cancer late effects skeletal adverse events survivorship YOUNG-ADULTS LONG-TERM SURVIVORS RISK-FACTORS BONE-MINERAL DENSITY OSTEONECROSIS CHILDREN ACUTE LYMPHOBLASTIC-LEUKEMIA PEDIATRIC-PATIENTS FRACTURES LYMPHOMA Bone Diseases/epidemiology Humans Child Preschool Infant Male Risk Scandinavian and Nordic Countries/epidemiology Young Adult Registries/statistics & numerical data Female Hospitalization/statistics & numerical data Neoplasms/epidemiology Cancer Survivors/statistics & numerical data Bone/epidemiology Adolescent Cohort Studies |
spellingShingle |
ALiCCS childhood cancer late effects skeletal adverse events survivorship YOUNG-ADULTS LONG-TERM SURVIVORS RISK-FACTORS BONE-MINERAL DENSITY OSTEONECROSIS CHILDREN ACUTE LYMPHOBLASTIC-LEUKEMIA PEDIATRIC-PATIENTS FRACTURES LYMPHOMA Bone Diseases/epidemiology Humans Child Preschool Infant Male Risk Scandinavian and Nordic Countries/epidemiology Young Adult Registries/statistics & numerical data Female Hospitalization/statistics & numerical data Neoplasms/epidemiology Cancer Survivors/statistics & numerical data Bone/epidemiology Adolescent Cohort Studies Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study |
topic_facet |
ALiCCS childhood cancer late effects skeletal adverse events survivorship YOUNG-ADULTS LONG-TERM SURVIVORS RISK-FACTORS BONE-MINERAL DENSITY OSTEONECROSIS CHILDREN ACUTE LYMPHOBLASTIC-LEUKEMIA PEDIATRIC-PATIENTS FRACTURES LYMPHOMA Bone Diseases/epidemiology Humans Child Preschool Infant Male Risk Scandinavian and Nordic Countries/epidemiology Young Adult Registries/statistics & numerical data Female Hospitalization/statistics & numerical data Neoplasms/epidemiology Cancer Survivors/statistics & numerical data Bone/epidemiology Adolescent Cohort Studies |
description |
The dynamic growth of the skeleton during childhood and adolescence renders it vulnerable to adverse effects of cancer treatment. The lifetime risk and patterns of skeletal morbidity have not been described in a population-based cohort of childhood cancer survivors. A cohort of 26 334 1-year cancer survivors diagnosed before 20 years of age was identified from the national cancer registries of Denmark, Finland, Iceland and Sweden as well as a cohort of 127 531 age- and sex-matched comparison subjects randomly selected from the national population registries in each country. The two cohorts were linked with data from the national hospital registries and the observed numbers of first-time hospital admissions for adverse skeletal outcomes among childhood cancer survivors were compared to the expected numbers derived from the comparison cohort. In total, 1987 childhood cancer survivors had at least one hospital admission with a skeletal adverse event as discharge diagnosis, yielding a rate ratio (RR) of 1.35 (95% confidence interval, 1.29-1.42). Among the survivors, we observed an increased risk for osteonecrosis with a RR of 25.9 (15.0-44.5), osteoporosis, RR 4.53 (3.28-6.27), fractures, RR 1.27 (1.20-1.34), osteochondropathies, RR 1.57 (1.28-1.92) and osteoarthrosis, RR 1.48 (1.28-1.72). The hospitalization risk for any skeletal adverse event was higher among survivors up to the age of 60 years, but the lifetime pattern was different for each type of skeletal adverse event. Understanding the different lifetime patterns and identification of high-risk groups is crucial for developing strategies to optimize skeletal health in childhood cancer survivors. |
format |
Article in Journal/Newspaper |
author |
Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck |
author_facet |
Oskarsson, Trausti Duun-Henriksen, Anne Katrine Bautz, Andrea Montgomery, Scott Harila-Saari, Arja Petersen, Cecilia Niinimäki, Riitta Madanat-Harjuoja, Laura Tryggvadóttir, Laufey Holmqvist, Anna Sällfors Hasle, Henrik Heyman, Mats Winther, Jeanette Falck |
author_sort |
Oskarsson, Trausti |
title |
Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_short |
Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full |
Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_fullStr |
Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_full_unstemmed |
Skeletal adverse events in childhood cancer survivors:An Adult Life after Childhood Cancer in Scandinavia cohort study |
title_sort |
skeletal adverse events in childhood cancer survivors:an adult life after childhood cancer in scandinavia cohort study |
publishDate |
2021 |
url |
https://pure.au.dk/portal/en/publications/fc7d292f-dc22-4155-b2a3-95d84bc49a4b https://doi.org/10.1002/ijc.33741 https://pure.au.dk/ws/files/274237614/Intl_Journal_of_Cancer_2021_Oskarsson_Skeletal_adverse_events_in_childhood_cancer_survivors_An_Adult_Life_after.pdf http://www.scopus.com/inward/record.url?scp=85111998976&partnerID=8YFLogxK |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Oskarsson , T , Duun-Henriksen , A K , Bautz , A , Montgomery , S , Harila-Saari , A , Petersen , C , Niinimäki , R , Madanat-Harjuoja , L , Tryggvadóttir , L , Holmqvist , A S , Hasle , H , Heyman , M , Winther , J F & ALiCCS Study Group 2021 , ' Skeletal adverse events in childhood cancer survivors : An Adult Life after Childhood Cancer in Scandinavia cohort study ' , International Journal of Cancer , vol. 149 , no. 11 , pp. 1863-1876 . https://doi.org/10.1002/ijc.33741 |
op_relation |
https://pure.au.dk/portal/en/publications/fc7d292f-dc22-4155-b2a3-95d84bc49a4b |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1002/ijc.33741 |
container_title |
International Journal of Cancer |
container_volume |
149 |
container_issue |
11 |
container_start_page |
1863 |
op_container_end_page |
1876 |
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1802646125241434112 |