High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study
Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n-6/n-3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial imp...
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1999
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ftuniaarhuspubl:oai:pure.atira.dk:publications/fc1ca160-983e-11da-bee9-02004c4f4f50 2023-05-15T16:06:39+02:00 High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study Pedersen, Henning Sloth Mortensen, S.A. Rhode, M. Deguchi, Y. Mulvad, Gert Bjerregaard, P. Hansen, Jens C. 1999 https://pure.au.dk/portal/da/publications/high-serum-coenzyme-q10-positively-correlated-with-age-selenium-and-cholesterol-in-inuit-of-greenland(fc1ca160-983e-11da-bee9-02004c4f4f50).html https://doi.org/10.1002/biof.5520090230 eng eng info:eu-repo/semantics/restrictedAccess Pedersen , H S , Mortensen , S A , Rhode , M , Deguchi , Y , Mulvad , G , Bjerregaard , P & Hansen , J C 1999 , ' High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland : A pilot study ' , BioFactors , vol. 9 , no. 2-4 , pp. 319-323 . https://doi.org/10.1002/biof.5520090230 article 1999 ftuniaarhuspubl https://doi.org/10.1002/biof.5520090230 2020-07-18T20:33:44Z Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n-6/n-3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial impact. From a health survey we chose the subpopulation from the most remote area, where the traditional Greenlandic diet with high intake of sea mammals and fish predominates. The mean (SD) of S-CoQ10 in males was 1.495 (0.529) nmol/ml and 1.421 (0.629) nmol/ml in females, significantly higher (p < 0.001) compared to a Danish population. In a linear multiple regression model the S-CoQ10 level is significantly positively associated with age and S-selenium in males, and S-total cholesterol in females. The high level of CoQ10 in Greenlanders probably reflects diet, since no bioaccumulation takes place, and it could probably be a substantial part of the antioxidative defense. Article in Journal/Newspaper eskimo* greenlander* greenlandic inuit Aarhus University: Research BioFactors 9 2-4 319 323 |
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Open Polar |
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Aarhus University: Research |
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ftuniaarhuspubl |
language |
English |
description |
Greenlanders (Eskimos) have low prevalence of ischaemic heart disease, partly explained by a lower extent of atherosclerosis and a low n-6/n-3 ratio of polyunsaturated fatty acids. As atherosclerosis is also a result of oxidative stress, the total antioxidative readiness could have a substantial impact. From a health survey we chose the subpopulation from the most remote area, where the traditional Greenlandic diet with high intake of sea mammals and fish predominates. The mean (SD) of S-CoQ10 in males was 1.495 (0.529) nmol/ml and 1.421 (0.629) nmol/ml in females, significantly higher (p < 0.001) compared to a Danish population. In a linear multiple regression model the S-CoQ10 level is significantly positively associated with age and S-selenium in males, and S-total cholesterol in females. The high level of CoQ10 in Greenlanders probably reflects diet, since no bioaccumulation takes place, and it could probably be a substantial part of the antioxidative defense. |
format |
Article in Journal/Newspaper |
author |
Pedersen, Henning Sloth Mortensen, S.A. Rhode, M. Deguchi, Y. Mulvad, Gert Bjerregaard, P. Hansen, Jens C. |
spellingShingle |
Pedersen, Henning Sloth Mortensen, S.A. Rhode, M. Deguchi, Y. Mulvad, Gert Bjerregaard, P. Hansen, Jens C. High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study |
author_facet |
Pedersen, Henning Sloth Mortensen, S.A. Rhode, M. Deguchi, Y. Mulvad, Gert Bjerregaard, P. Hansen, Jens C. |
author_sort |
Pedersen, Henning Sloth |
title |
High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study |
title_short |
High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study |
title_full |
High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study |
title_fullStr |
High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study |
title_full_unstemmed |
High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland:A pilot study |
title_sort |
high serum coenzyme q10, positively correlated with age, selenium and cholesterol in inuit of greenland:a pilot study |
publishDate |
1999 |
url |
https://pure.au.dk/portal/da/publications/high-serum-coenzyme-q10-positively-correlated-with-age-selenium-and-cholesterol-in-inuit-of-greenland(fc1ca160-983e-11da-bee9-02004c4f4f50).html https://doi.org/10.1002/biof.5520090230 |
genre |
eskimo* greenlander* greenlandic inuit |
genre_facet |
eskimo* greenlander* greenlandic inuit |
op_source |
Pedersen , H S , Mortensen , S A , Rhode , M , Deguchi , Y , Mulvad , G , Bjerregaard , P & Hansen , J C 1999 , ' High serum coenzyme Q10, positively correlated with age, selenium and cholesterol in Inuit of Greenland : A pilot study ' , BioFactors , vol. 9 , no. 2-4 , pp. 319-323 . https://doi.org/10.1002/biof.5520090230 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1002/biof.5520090230 |
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BioFactors |
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9 |
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