A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis
Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430)...
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ftuniaarhuspubl:oai:pure.atira.dk:publications/f74a643b-7d4c-4ddc-af3c-42fcad09ef09 2023-05-15T16:50:15+02:00 A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis Bell, Steven Rigas, Andreas S. Magnusson, Magnus K. Ferkingstad, Egil Allara, Elias Bjornsdottir, Gyda Ramond, Anna Sørensen, Erik Halldorsson, Gisli H. Paul, Dirk S. Burgdorf, Kristoffer S. Eggertsson, Hannes P. Howson, Joanna M.M. Thørner, Lise W. Kristmundsdottir, Snaedis Astle, William J. Erikstrup, Christian Sigurdsson, Jon K. Vuckovic, Dragana Dinh, Khoa M. Tragante, Vinicius Surendran, Praveen Pedersen, Ole B. Vidarsson, Brynjar Jiang, Tao Paarup, Helene M. Onundarson, Pall T. Akbari, Parsa Nielsen, Kaspar R. Lund, Sigrun H. Juliusson, Kristinn Magnusson, Magnus I. Frigge, Michael L. Oddsson, Asmundur Olafsson, Isleifur Kaptoge, Stephen Hjalgrim, Henrik Runarsson, Gudmundur Wood, Angela M. Jonsdottir, Ingileif Hansen, Thomas F. Sigurdardottir, Olof Stefansson, Hreinn 2021-12 https://pure.au.dk/portal/da/publications/a-genomewide-metaanalysis-yields-46-new-loci-associating-with-biomarkers-of-iron-homeostasis(f74a643b-7d4c-4ddc-af3c-42fcad09ef09).html https://doi.org/10.1038/s42003-020-01575-z http://www.scopus.com/inward/record.url?scp=85100560134&partnerID=8YFLogxK eng eng info:eu-repo/semantics/openAccess Bell , S , Rigas , A S , Magnusson , M K , Ferkingstad , E , Allara , E , Bjornsdottir , G , Ramond , A , Sørensen , E , Halldorsson , G H , Paul , D S , Burgdorf , K S , Eggertsson , H P , Howson , J M M , Thørner , L W , Kristmundsdottir , S , Astle , W J , Erikstrup , C , Sigurdsson , J K , Vuckovic , D , Dinh , K M , Tragante , V , Surendran , P , Pedersen , O B , Vidarsson , B , Jiang , T , Paarup , H M , Onundarson , P T , Akbari , P , Nielsen , K R , Lund , S H , Juliusson , K , Magnusson , M I , Frigge , M L , Oddsson , A , Olafsson , I , Kaptoge , S , Hjalgrim , H , Runarsson , G , Wood , A M , Jonsdottir , I , Hansen , T F , Sigurdardottir , O , Stefansson , H & DBDS Genomic Consortium 2021 , ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ' , Communications Biology , vol. 4 , no. 1 , 156 . https://doi.org/10.1038/s42003-020-01575-z article 2021 ftuniaarhuspubl https://doi.org/10.1038/s42003-020-01575-z 2021-10-27T22:47:22Z Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation. Article in Journal/Newspaper Iceland Aarhus University: Research Communications Biology 4 1 |
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Aarhus University: Research |
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ftuniaarhuspubl |
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Iron is essential for many biological functions and iron deficiency and overload have major health implications. We performed a meta-analysis of three genome-wide association studies from Iceland, the UK and Denmark of blood levels of ferritin (N = 246,139), total iron binding capacity (N = 135,430), iron (N = 163,511) and transferrin saturation (N = 131,471). We found 62 independent sequence variants associating with iron homeostasis parameters at 56 loci, including 46 novel loci. Variants at DUOX2, F5, SLC11A2 and TMPRSS6 associate with iron deficiency anemia, while variants at TF, HFE, TFR2 and TMPRSS6 associate with iron overload. A HBS1L-MYB intergenic region variant associates both with increased risk of iron overload and reduced risk of iron deficiency anemia. The DUOX2 missense variant is present in 14% of the population, associates with all iron homeostasis biomarkers, and increases the risk of iron deficiency anemia by 29%. The associations implicate proteins contributing to the main physiological processes involved in iron homeostasis: iron sensing and storage, inflammation, absorption of iron from the gut, iron recycling, erythropoiesis and bleeding/menstruation. |
format |
Article in Journal/Newspaper |
author |
Bell, Steven Rigas, Andreas S. Magnusson, Magnus K. Ferkingstad, Egil Allara, Elias Bjornsdottir, Gyda Ramond, Anna Sørensen, Erik Halldorsson, Gisli H. Paul, Dirk S. Burgdorf, Kristoffer S. Eggertsson, Hannes P. Howson, Joanna M.M. Thørner, Lise W. Kristmundsdottir, Snaedis Astle, William J. Erikstrup, Christian Sigurdsson, Jon K. Vuckovic, Dragana Dinh, Khoa M. Tragante, Vinicius Surendran, Praveen Pedersen, Ole B. Vidarsson, Brynjar Jiang, Tao Paarup, Helene M. Onundarson, Pall T. Akbari, Parsa Nielsen, Kaspar R. Lund, Sigrun H. Juliusson, Kristinn Magnusson, Magnus I. Frigge, Michael L. Oddsson, Asmundur Olafsson, Isleifur Kaptoge, Stephen Hjalgrim, Henrik Runarsson, Gudmundur Wood, Angela M. Jonsdottir, Ingileif Hansen, Thomas F. Sigurdardottir, Olof Stefansson, Hreinn |
spellingShingle |
Bell, Steven Rigas, Andreas S. Magnusson, Magnus K. Ferkingstad, Egil Allara, Elias Bjornsdottir, Gyda Ramond, Anna Sørensen, Erik Halldorsson, Gisli H. Paul, Dirk S. Burgdorf, Kristoffer S. Eggertsson, Hannes P. Howson, Joanna M.M. Thørner, Lise W. Kristmundsdottir, Snaedis Astle, William J. Erikstrup, Christian Sigurdsson, Jon K. Vuckovic, Dragana Dinh, Khoa M. Tragante, Vinicius Surendran, Praveen Pedersen, Ole B. Vidarsson, Brynjar Jiang, Tao Paarup, Helene M. Onundarson, Pall T. Akbari, Parsa Nielsen, Kaspar R. Lund, Sigrun H. Juliusson, Kristinn Magnusson, Magnus I. Frigge, Michael L. Oddsson, Asmundur Olafsson, Isleifur Kaptoge, Stephen Hjalgrim, Henrik Runarsson, Gudmundur Wood, Angela M. Jonsdottir, Ingileif Hansen, Thomas F. Sigurdardottir, Olof Stefansson, Hreinn A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
author_facet |
Bell, Steven Rigas, Andreas S. Magnusson, Magnus K. Ferkingstad, Egil Allara, Elias Bjornsdottir, Gyda Ramond, Anna Sørensen, Erik Halldorsson, Gisli H. Paul, Dirk S. Burgdorf, Kristoffer S. Eggertsson, Hannes P. Howson, Joanna M.M. Thørner, Lise W. Kristmundsdottir, Snaedis Astle, William J. Erikstrup, Christian Sigurdsson, Jon K. Vuckovic, Dragana Dinh, Khoa M. Tragante, Vinicius Surendran, Praveen Pedersen, Ole B. Vidarsson, Brynjar Jiang, Tao Paarup, Helene M. Onundarson, Pall T. Akbari, Parsa Nielsen, Kaspar R. Lund, Sigrun H. Juliusson, Kristinn Magnusson, Magnus I. Frigge, Michael L. Oddsson, Asmundur Olafsson, Isleifur Kaptoge, Stephen Hjalgrim, Henrik Runarsson, Gudmundur Wood, Angela M. Jonsdottir, Ingileif Hansen, Thomas F. Sigurdardottir, Olof Stefansson, Hreinn |
author_sort |
Bell, Steven |
title |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_short |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_full |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_fullStr |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_full_unstemmed |
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
title_sort |
genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis |
publishDate |
2021 |
url |
https://pure.au.dk/portal/da/publications/a-genomewide-metaanalysis-yields-46-new-loci-associating-with-biomarkers-of-iron-homeostasis(f74a643b-7d4c-4ddc-af3c-42fcad09ef09).html https://doi.org/10.1038/s42003-020-01575-z http://www.scopus.com/inward/record.url?scp=85100560134&partnerID=8YFLogxK |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Bell , S , Rigas , A S , Magnusson , M K , Ferkingstad , E , Allara , E , Bjornsdottir , G , Ramond , A , Sørensen , E , Halldorsson , G H , Paul , D S , Burgdorf , K S , Eggertsson , H P , Howson , J M M , Thørner , L W , Kristmundsdottir , S , Astle , W J , Erikstrup , C , Sigurdsson , J K , Vuckovic , D , Dinh , K M , Tragante , V , Surendran , P , Pedersen , O B , Vidarsson , B , Jiang , T , Paarup , H M , Onundarson , P T , Akbari , P , Nielsen , K R , Lund , S H , Juliusson , K , Magnusson , M I , Frigge , M L , Oddsson , A , Olafsson , I , Kaptoge , S , Hjalgrim , H , Runarsson , G , Wood , A M , Jonsdottir , I , Hansen , T F , Sigurdardottir , O , Stefansson , H & DBDS Genomic Consortium 2021 , ' A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis ' , Communications Biology , vol. 4 , no. 1 , 156 . https://doi.org/10.1038/s42003-020-01575-z |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1038/s42003-020-01575-z |
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Communications Biology |
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4 |
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