Temporal monitoring of liver and kidney lesions in contaminated East Greenland polar bears (Ursus maritimus) during 1999-2010

Organohalogen contaminants bioaccumulate to high concentrations in tissues of polar bears (Ursus maritimus). The exposure levels are in the order to be toxic to inner organs like liver and kidney. We therefore investigated the temporal development of lesions in liver (n=115) and kidney (n=122) sampl...

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Bibliographic Details
Published in:Environment International
Main Authors: Sonne, Christian, Letcher, Robert J, Leifsson, Pall S, Rigét, Frank F, Bechshøft, Thea Ø, Bossi, Rossana, Asmund, Gert, Dietz, Rune
Format: Article in Journal/Newspaper
Language:English
Published: 2012
Subjects:
Greenland
East Greenland
Ursus maritimus
Online Access:https://pure.au.dk/portal/da/publications/temporal-monitoring-of-liver-and-kidney-lesions-in-contaminated-east-greenland-polar-bears-ursus-maritimus-during-19992010(f1bd7738-5afb-473b-8510-060421730aaf).html
https://doi.org/10.1016/j.envint.2012.07.002
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Summary:Organohalogen contaminants bioaccumulate to high concentrations in tissues of polar bears (Ursus maritimus). The exposure levels are in the order to be toxic to inner organs like liver and kidney. We therefore investigated the temporal development of lesions in liver (n=115) and kidney (n=122) samples from East Greenland polar bears taken over the 12year period from 1999 to 2010. Seven liver and seven kidney lesions were observed of which six were age-related. Controlling for this, the analyses showed that hepatic steatosis and renal cell infiltrations, glomerular sclerosis and tubular hyperplasia decreased over the investigated time period (all p

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