Intracellular compartmentation of cardiac fibres from rainbow trout and Atlantic cod - a general design of heart cells
Previously identified, potentially neuroprotective reactions of neuroglobin require the existence of yet unknown redox partners. We show here that the reduction of ferric neuroglobin by cytochrome b 5 is relatively slow ( k =6×102M-1s-1 at pH 7.0) and thus is unlikely to be of physiological signific...
| Published in: | Biochimica et Biophysica Acta (BBA) - Bioenergetics |
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| Main Authors: | , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://pure.au.dk/portal/da/publications/intracellular-compartmentation-of-cardiac-fibres-from-rainbow-trout-and-atlantic-cod--a-general-design-of-heart-cells(eee290d0-dd1c-11db-bee9-02004c4f4f50).html https://doi.org/10.1016/j.bbabio.2006.04.022 |
| Summary: | Previously identified, potentially neuroprotective reactions of neuroglobin require the existence of yet unknown redox partners. We show here that the reduction of ferric neuroglobin by cytochrome b 5 is relatively slow ( k =6×102M-1s-1 at pH 7.0) and thus is unlikely to be of physiological significance. In contrast, the reaction between ferrous neuroglobin and ferric cytochrome c is very rapid ( k =2×107M-1s-1) with an apparent overall equilibrium constant of 1μM. Based on this data we propose that ferrous neuroglobin may well play a role in preventing apoptosis |
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