Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output
Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the role...
Published in: | Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/cd285c4d-3027-45a0-bebc-5d1ef850bde9 2024-09-09T19:04:34+00:00 Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output Joyce, William Egginton, Stuart Farrell, Anthony P. Axelsson, Michael 2019 https://pure.au.dk/portal/en/publications/cd285c4d-3027-45a0-bebc-5d1ef850bde9 https://doi.org/10.1016/j.cbpa.2018.12.012 http://www.scopus.com/inward/record.url?scp=85059345699&partnerID=8YFLogxK eng eng https://pure.au.dk/portal/en/publications/cd285c4d-3027-45a0-bebc-5d1ef850bde9 info:eu-repo/semantics/closedAccess Joyce , W , Egginton , S , Farrell , A P & Axelsson , M 2019 , ' Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish : Insight into central and peripheral determinants of cardiac output ' , Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology , vol. 230 , pp. 28-38 . https://doi.org/10.1016/j.cbpa.2018.12.012 Adenosine Adrenaline Channichthyidae Conductance Heart rate article 2019 ftuniaarhuspubl https://doi.org/10.1016/j.cbpa.2018.12.012 2024-06-18T14:19:38Z Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒ H ), adrenaline (5 nmol kg −1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (G sys ). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg −1 ) generated a large increase in Q̇ by increasing G sys , a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart. Article in Journal/Newspaper Antarc* Antarctic Icefish Aarhus University: Research Antarctic Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 230 28 38 |
institution |
Open Polar |
collection |
Aarhus University: Research |
op_collection_id |
ftuniaarhuspubl |
language |
English |
topic |
Adenosine Adrenaline Channichthyidae Conductance Heart rate |
spellingShingle |
Adenosine Adrenaline Channichthyidae Conductance Heart rate Joyce, William Egginton, Stuart Farrell, Anthony P. Axelsson, Michael Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output |
topic_facet |
Adenosine Adrenaline Channichthyidae Conductance Heart rate |
description |
Icefishes characteristically lack the oxygen-binding protein haemoglobin and therefore are especially reliant on cardiovascular regulation to augment oxygen transport when oxygen demand increases, such as during activity and warming. Using both in vivo and in vitro experiments, we evaluated the roles for adrenaline and adenosine, two well-established cardio- and vasoactive molecules, in regulating the cardiovascular system of the blackfin icefish, Chaenocephalus aceratus. Despite increasing cardiac contractility (increasing twitch force and contraction kinetics in isometric myocardial strip preparations) and accelerating heart rate (ƒ H ), adrenaline (5 nmol kg −1 bolus intra-arterial injection) did not significantly increase cardiac output (Q̇) in vivo because it elicited a large decrease in vascular conductance (G sys ). In contrast, and despite preliminary data suggesting a direct negative inotropic effect of adenosine on isolated atria and little effect on isolated ventricle strips, adenosine (500 nmol kg −1 ) generated a large increase in Q̇ by increasing G sys , a change reminiscent of that previously reported during both acute warming and invoked activity. Our data thus illustrate how Q̇ in C. aceratus may be much more dependent on peripheral control of vasomotor tone than direct regulation of the heart. |
format |
Article in Journal/Newspaper |
author |
Joyce, William Egginton, Stuart Farrell, Anthony P. Axelsson, Michael |
author_facet |
Joyce, William Egginton, Stuart Farrell, Anthony P. Axelsson, Michael |
author_sort |
Joyce, William |
title |
Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output |
title_short |
Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output |
title_full |
Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output |
title_fullStr |
Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output |
title_full_unstemmed |
Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish:Insight into central and peripheral determinants of cardiac output |
title_sort |
adrenergic and adenosinergic regulation of the cardiovascular system in an antarctic icefish:insight into central and peripheral determinants of cardiac output |
publishDate |
2019 |
url |
https://pure.au.dk/portal/en/publications/cd285c4d-3027-45a0-bebc-5d1ef850bde9 https://doi.org/10.1016/j.cbpa.2018.12.012 http://www.scopus.com/inward/record.url?scp=85059345699&partnerID=8YFLogxK |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Icefish |
genre_facet |
Antarc* Antarctic Icefish |
op_source |
Joyce , W , Egginton , S , Farrell , A P & Axelsson , M 2019 , ' Adrenergic and adenosinergic regulation of the cardiovascular system in an Antarctic icefish : Insight into central and peripheral determinants of cardiac output ' , Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology , vol. 230 , pp. 28-38 . https://doi.org/10.1016/j.cbpa.2018.12.012 |
op_relation |
https://pure.au.dk/portal/en/publications/cd285c4d-3027-45a0-bebc-5d1ef850bde9 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1016/j.cbpa.2018.12.012 |
container_title |
Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology |
container_volume |
230 |
container_start_page |
28 |
op_container_end_page |
38 |
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1809818584417828864 |