Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior
Phytosterols and their esters have been reported as a cholesterol lowering agent in human. However, natural phytosterols have a low solubility in both water and fat resulting in a poor absorption in intestine. To improve the intestinal absorption and bioavailability of phytosterols, conversion of ph...
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ftuniaarhuspubl:oai:pure.atira.dk:publications/ccf75df5-9146-467b-9ac4-e3f732035812 2023-05-15T13:43:20+02:00 Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior Panpipat, Worawan Xu, Xuebing Guo, Zheng 2012-09 application/pdf https://pure.au.dk/portal/da/publications/lipophilic-phytosterol-derivatives-synthesis-thermal-property-and-nanoemulsion-behavior(ccf75df5-9146-467b-9ac4-e3f732035812).html https://pure.au.dk/ws/files/55296045/Abstract_Eurofed_lipid_2012_conference_vesion.pdf eng eng info:eu-repo/semantics/restrictedAccess Panpipat , W , Xu , X & Guo , Z 2012 , ' Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior ' , 10th Euro Fed Lipid Congress , Krakow , Poland , 23/09/2012 - 26/09/2012 . conferenceObject 2012 ftuniaarhuspubl 2020-07-18T21:24:11Z Phytosterols and their esters have been reported as a cholesterol lowering agent in human. However, natural phytosterols have a low solubility in both water and fat resulting in a poor absorption in intestine. To improve the intestinal absorption and bioavailability of phytosterols, conversion of phytosterols into enzyme-liable lipophilic derivatives, such as fatty acid esters was one of the possible strategies. Differences in molecular structures of modified phytosterols may result in the differences in their thermal and micelling behaviors. Therefore, the objectives of this study were to improve the productive yield of a series of -sitosteryl fatty acid esters (C2-C18) and to investigate the thermal property and nano-emulsion behaviors of those compounds. This work reported a novel approach to synthesize phytosterol (-sitosterol as a model) fatty acid ester by employing Candida antarctica lipase A (CAL A) which showed a superior catalytic activity towards secondary alcohol to another lipases. Series of -sitosteryl fatty acid esters (C2-C18) were successfully prepared and their molecular structures were identified by 1HNMR and Fourier transform-infrared spectroscopy (FTIR). The thermal property of -sitosterol fatty acid esters was governed by the carbon chain length of fatty acid incorporated. The nano-emulsions of a series of -sitosteryl fatty acid esters were prepared by probe-sonication method. The particle size distributions, zeta potentials and TEM images of those emulsions were different depending upon their structures. Conference Object Antarc* Antarctica Aarhus University: Research |
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Aarhus University: Research |
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ftuniaarhuspubl |
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English |
description |
Phytosterols and their esters have been reported as a cholesterol lowering agent in human. However, natural phytosterols have a low solubility in both water and fat resulting in a poor absorption in intestine. To improve the intestinal absorption and bioavailability of phytosterols, conversion of phytosterols into enzyme-liable lipophilic derivatives, such as fatty acid esters was one of the possible strategies. Differences in molecular structures of modified phytosterols may result in the differences in their thermal and micelling behaviors. Therefore, the objectives of this study were to improve the productive yield of a series of -sitosteryl fatty acid esters (C2-C18) and to investigate the thermal property and nano-emulsion behaviors of those compounds. This work reported a novel approach to synthesize phytosterol (-sitosterol as a model) fatty acid ester by employing Candida antarctica lipase A (CAL A) which showed a superior catalytic activity towards secondary alcohol to another lipases. Series of -sitosteryl fatty acid esters (C2-C18) were successfully prepared and their molecular structures were identified by 1HNMR and Fourier transform-infrared spectroscopy (FTIR). The thermal property of -sitosterol fatty acid esters was governed by the carbon chain length of fatty acid incorporated. The nano-emulsions of a series of -sitosteryl fatty acid esters were prepared by probe-sonication method. The particle size distributions, zeta potentials and TEM images of those emulsions were different depending upon their structures. |
format |
Conference Object |
author |
Panpipat, Worawan Xu, Xuebing Guo, Zheng |
spellingShingle |
Panpipat, Worawan Xu, Xuebing Guo, Zheng Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior |
author_facet |
Panpipat, Worawan Xu, Xuebing Guo, Zheng |
author_sort |
Panpipat, Worawan |
title |
Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior |
title_short |
Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior |
title_full |
Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior |
title_fullStr |
Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior |
title_full_unstemmed |
Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior |
title_sort |
lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior |
publishDate |
2012 |
url |
https://pure.au.dk/portal/da/publications/lipophilic-phytosterol-derivatives-synthesis-thermal-property-and-nanoemulsion-behavior(ccf75df5-9146-467b-9ac4-e3f732035812).html https://pure.au.dk/ws/files/55296045/Abstract_Eurofed_lipid_2012_conference_vesion.pdf |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Panpipat , W , Xu , X & Guo , Z 2012 , ' Lipophilic phytosterol derivatives: synthesis, thermal property and nanoemulsion behavior ' , 10th Euro Fed Lipid Congress , Krakow , Poland , 23/09/2012 - 26/09/2012 . |
op_rights |
info:eu-repo/semantics/restrictedAccess |
_version_ |
1766187823673638912 |