Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS)
OBJECTIVES: The pattern of autoimmune diseases in childhood cancer survivors has not been investigated previously. We estimated the risk for an autoimmune disease after childhood cancer in a large, population-based setting with outcome measures from comprehensive, nationwide health registries. METHO...
Published in: | Annals of the Rheumatic Diseases |
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2015
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Online Access: | https://pure.au.dk/portal/da/publications/autoimmune-diseases-in-adult-life-after-childhood-cancer-in-scandinavia-aliccs(c6949765-356b-4c4a-b84c-5e9e027517fb).html https://doi.org/10.1136/annrheumdis-2015-207659 |
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ftuniaarhuspubl:oai:pure.atira.dk:publications/c6949765-356b-4c4a-b84c-5e9e027517fb 2023-05-15T16:51:10+02:00 Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) Holmqvist, Anna Sällfors Olsen, Jørgen H. Mellemkjaer, Lene Garwicz, Stanislaw Hjorth, Lars Moëll, Christian Månsson, Bengt Tryggvadottir, Laufey Hasle, Henrik Winther, Jeanette Falck 2015-11-10 https://pure.au.dk/portal/da/publications/autoimmune-diseases-in-adult-life-after-childhood-cancer-in-scandinavia-aliccs(c6949765-356b-4c4a-b84c-5e9e027517fb).html https://doi.org/10.1136/annrheumdis-2015-207659 eng eng info:eu-repo/semantics/restrictedAccess Holmqvist , A S , Olsen , J H , Mellemkjaer , L , Garwicz , S , Hjorth , L , Moëll , C , Månsson , B , Tryggvadottir , L , Hasle , H , Winther , J F & ALiCCS Study Group 2015 , ' Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) ' , Annals of the Rheumatic Diseases , vol. 75 , no. 9 , pp. 1622-9 . https://doi.org/10.1136/annrheumdis-2015-207659 article 2015 ftuniaarhuspubl https://doi.org/10.1136/annrheumdis-2015-207659 2021-09-22T22:46:09Z OBJECTIVES: The pattern of autoimmune diseases in childhood cancer survivors has not been investigated previously. We estimated the risk for an autoimmune disease after childhood cancer in a large, population-based setting with outcome measures from comprehensive, nationwide health registries. METHODS: From the national cancer registries of Denmark, Iceland and Sweden, we identified 20 361 1-year survivors of cancer diagnosed before the age of 20 between the start of cancer registration in the 1940s and 1950s through 2008; 125 794 comparison subjects, matched by age, gender and country, were selected from national population registers. Study subjects were linked to the national hospital registers. Standardised hospitalisation rate ratios (SHRRs) and absolute excess risks (AERs) were calculated. RESULTS: Childhood cancer survivors had a significantly increased SHRR of 1.4 (95% CI 1.3 to 1.5) of all autoimmune diseases combined, corresponding to an AER of 67 per 100 000 person-years. The SHRRs were significantly increased for autoimmune haemolytic anaemia (16.3), Addison's disease (13.9), polyarteritis nodosa (5.8), chronic rheumatic heart disease (4.5), localised scleroderma (3.6), idiopathic thrombocytopenic purpura (3.4), Hashimoto's thyroiditis (3.1), pernicious anaemia (2.7), sarcoidosis (2.2), Sjögren's syndrome (2.0) and insulin-dependent diabetes mellitus (1.6). The SHRRs for any autoimmune disease were significantly increased after leukaemia (SHRR 1.6), Hodgkin's lymphoma (1.6), renal tumours (1.6) and central nervous system neoplasms (1.4). CONCLUSIONS: Childhood cancer survivors are at increased risk for certain types of autoimmune diseases. These findings underscore the need for prolonged follow-up of these survivors. Article in Journal/Newspaper Iceland Aarhus University: Research Annals of the Rheumatic Diseases 75 9 1622 1629 |
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Aarhus University: Research |
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ftuniaarhuspubl |
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English |
description |
OBJECTIVES: The pattern of autoimmune diseases in childhood cancer survivors has not been investigated previously. We estimated the risk for an autoimmune disease after childhood cancer in a large, population-based setting with outcome measures from comprehensive, nationwide health registries. METHODS: From the national cancer registries of Denmark, Iceland and Sweden, we identified 20 361 1-year survivors of cancer diagnosed before the age of 20 between the start of cancer registration in the 1940s and 1950s through 2008; 125 794 comparison subjects, matched by age, gender and country, were selected from national population registers. Study subjects were linked to the national hospital registers. Standardised hospitalisation rate ratios (SHRRs) and absolute excess risks (AERs) were calculated. RESULTS: Childhood cancer survivors had a significantly increased SHRR of 1.4 (95% CI 1.3 to 1.5) of all autoimmune diseases combined, corresponding to an AER of 67 per 100 000 person-years. The SHRRs were significantly increased for autoimmune haemolytic anaemia (16.3), Addison's disease (13.9), polyarteritis nodosa (5.8), chronic rheumatic heart disease (4.5), localised scleroderma (3.6), idiopathic thrombocytopenic purpura (3.4), Hashimoto's thyroiditis (3.1), pernicious anaemia (2.7), sarcoidosis (2.2), Sjögren's syndrome (2.0) and insulin-dependent diabetes mellitus (1.6). The SHRRs for any autoimmune disease were significantly increased after leukaemia (SHRR 1.6), Hodgkin's lymphoma (1.6), renal tumours (1.6) and central nervous system neoplasms (1.4). CONCLUSIONS: Childhood cancer survivors are at increased risk for certain types of autoimmune diseases. These findings underscore the need for prolonged follow-up of these survivors. |
format |
Article in Journal/Newspaper |
author |
Holmqvist, Anna Sällfors Olsen, Jørgen H. Mellemkjaer, Lene Garwicz, Stanislaw Hjorth, Lars Moëll, Christian Månsson, Bengt Tryggvadottir, Laufey Hasle, Henrik Winther, Jeanette Falck |
spellingShingle |
Holmqvist, Anna Sällfors Olsen, Jørgen H. Mellemkjaer, Lene Garwicz, Stanislaw Hjorth, Lars Moëll, Christian Månsson, Bengt Tryggvadottir, Laufey Hasle, Henrik Winther, Jeanette Falck Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) |
author_facet |
Holmqvist, Anna Sällfors Olsen, Jørgen H. Mellemkjaer, Lene Garwicz, Stanislaw Hjorth, Lars Moëll, Christian Månsson, Bengt Tryggvadottir, Laufey Hasle, Henrik Winther, Jeanette Falck |
author_sort |
Holmqvist, Anna Sällfors |
title |
Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) |
title_short |
Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) |
title_full |
Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) |
title_fullStr |
Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) |
title_full_unstemmed |
Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) |
title_sort |
autoimmune diseases in adult life after childhood cancer in scandinavia (aliccs) |
publishDate |
2015 |
url |
https://pure.au.dk/portal/da/publications/autoimmune-diseases-in-adult-life-after-childhood-cancer-in-scandinavia-aliccs(c6949765-356b-4c4a-b84c-5e9e027517fb).html https://doi.org/10.1136/annrheumdis-2015-207659 |
genre |
Iceland |
genre_facet |
Iceland |
op_source |
Holmqvist , A S , Olsen , J H , Mellemkjaer , L , Garwicz , S , Hjorth , L , Moëll , C , Månsson , B , Tryggvadottir , L , Hasle , H , Winther , J F & ALiCCS Study Group 2015 , ' Autoimmune diseases in Adult Life after Childhood Cancer in Scandinavia (ALiCCS) ' , Annals of the Rheumatic Diseases , vol. 75 , no. 9 , pp. 1622-9 . https://doi.org/10.1136/annrheumdis-2015-207659 |
op_rights |
info:eu-repo/semantics/restrictedAccess |
op_doi |
https://doi.org/10.1136/annrheumdis-2015-207659 |
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Annals of the Rheumatic Diseases |
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75 |
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9 |
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1622 |
op_container_end_page |
1629 |
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1766041271060660224 |